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407950 Sigma-AldrichIonomycin, Free Acid, Streptomyces conglobatus - CAS 56092-81-0 - Calbiochem

Ionomycin, Free Acid, Streptomyces conglobatus, CAS 56092-81-0, is an ionophore with high specificity for divalent cations. More effective than A23187 as a mobile ion carrier for Ca2+.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
小册子
Data Sheet
Citations

Recommended Products

概述

Replacement Information

重要规格表

CAS #	Empirical Formula
56092-81-0	C₄₁H₇₂O₉

价格及供货情况

产品目录编号	库存情况	包装	数量 / 包装	价格	数量
407950-10MGCN	正在查询供货情况...... — 目前缺货有货停产少量现货供货情况有待确认登录查看库存有货目前缺货有货其余：另行通知其余：另行通知另行通知联系客户服务 Contact Customer Service 联系客户服务联系客户服务	塑胶安瓿;塑胶针药瓶	10 mg	正在检索价格...... 无法检索价格。最小订购数量为倍数 Maximum Quantity is 以订单确认为准更多信息您节约了 ()。 — Request Pricing 登录查看价格	查看库存情况 —	添加到收藏夹添加到收藏夹添加到我的收藏夹
407950-1MGCN	正在查询供货情况...... — 目前缺货有货停产少量现货供货情况有待确认登录查看库存有货目前缺货有货其余：另行通知其余：另行通知另行通知联系客户服务 Contact Customer Service 联系客户服务联系客户服务	塑胶安瓿;塑胶针药瓶	1 mg	正在检索价格...... 无法检索价格。最小订购数量为倍数 Maximum Quantity is 以订单确认为准更多信息您节约了 ()。 — Request Pricing 登录查看价格	查看库存情况 —	添加到收藏夹添加到收藏夹添加到我的收藏夹
407950-5MGCN	正在查询供货情况...... — 目前缺货有货停产少量现货供货情况有待确认登录查看库存有货目前缺货有货其余：另行通知其余：另行通知另行通知联系客户服务 Contact Customer Service 联系客户服务联系客户服务	塑胶安瓿;塑胶针药瓶	5 mg	正在检索价格...... 无法检索价格。最小订购数量为倍数 Maximum Quantity is 以订单确认为准更多信息您节约了 ()。 — Request Pricing 登录查看价格	查看库存情况 —	添加到收藏夹添加到收藏夹添加到我的收藏夹

Description
Overview	Highly specific for divalent cations and more effective than A23187 (Cat. No. 100105) as a mobile ion carrier for Ca²⁺. Complexes with Ca²⁺between pH 7 and 9.5. In contrast to A23187, it is not fluorescent. Useful for studies of Ca²⁺ transport across biological membranes and measurement of cytoplasmic free Ca²⁺. Induces apoptotic neuronal degeneration in embryonic cortical neurons and cell cycle arrest in the G₁ phase in mature Burkitt lymphoma cell lines.
Overview	Absorption max. (280 nm, MeOH): 18,600 M^-1cm^-1.
Catalogue Number	407950
Brand Family	Calbiochem®

References
References	Aagaard-Tillery, K.M., and Jelinek, D.F. 1995. J. Immunol. 155, 3297. Takei, N., and Endo, Y. 1994. Brain Res. 652, 65. Dupuy d’Angeac, A., et al. 1993. J. Cell Physiol. 154, 44. Lee, H.C. 1993. J. Biol. Chem. 268, 293. Kuznetsov, G., et al. 1992. J. Biol. Chem. 267, 3932. Toeplitz, B.K., et al. 1979. J. Am. Chem. Soc. 101, 3344. Liu, C.M., and Hermann, T.E. 1978. J. Biol. Chem. 253, 5892.

References

Aagaard-Tillery, K.M., and Jelinek, D.F. 1995. J. Immunol. 155, 3297.
Takei, N., and Endo, Y. 1994. Brain Res. 652, 65.
Dupuy d’Angeac, A., et al. 1993. J. Cell Physiol. 154, 44.
Lee, H.C. 1993. J. Biol. Chem. 268, 293.
Kuznetsov, G., et al. 1992. J. Biol. Chem. 267, 3932.
Toeplitz, B.K., et al. 1979. J. Am. Chem. Soc. 101, 3344.
Liu, C.M., and Hermann, T.E. 1978. J. Biol. Chem. 253, 5892.

Product Information
CAS number	56092-81-0
ATP Competitive	N
Form	Waxy solid
Hill Formula	C₄₁H₇₂O₉
Chemical formula	C₄₁H₇₂O₉
Reversible	N
Structure formula Image
Quality Level	MQ100

Applications
Application	Ionomycin, Free Acid, Streptomyces conglobatus, CAS 56092-81-0, is an ionophore with high specificity for divalent cations. More effective than A23187 as a mobile ion carrier for Ca2+.

Biological Information
Primary Target	Mobile ion carrier for Ca2+
Purity	≥90% by HPLC

Physicochemical Information
Cell permeable	N

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS
RTECS	NO0600000

Safety Information
R Phrase	R: 22 Harmful if swallowed.
S Phrase	S: 36 Wear suitable protective clothing.

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Harmful
Storage	+2°C to +8°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 1 year at 4°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
407950-10MGCN	04055977211566
407950-1MGCN	04055977211559
407950-5MGCN	04055977211573

Documentation

Ionomycin, Free Acid, Streptomyces conglobatus - CAS 56092-81-0 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

Ionomycin, Free Acid, Streptomyces conglobatus - CAS 56092-81-0 - Calbiochem 分析证书

标题	批号
407950	输入批号

参考

参考信息概述
Aagaard-Tillery, K.M., and Jelinek, D.F. 1995. J. Immunol. 155, 3297. Takei, N., and Endo, Y. 1994. Brain Res. 652, 65. Dupuy d’Angeac, A., et al. 1993. J. Cell Physiol. 154, 44. Lee, H.C. 1993. J. Biol. Chem. 268, 293. Kuznetsov, G., et al. 1992. J. Biol. Chem. 267, 3932. Toeplitz, B.K., et al. 1979. J. Am. Chem. Soc. 101, 3344. Liu, C.M., and Hermann, T.E. 1978. J. Biol. Chem. 253, 5892.

参考信息概述

小册子

标题
Caspases and other Apoptosis Related Tools Brochure

引用

标题

Jonathan Rios-Doria, et al. (2004) Cleavage of b-catenin by calpain in prostate and mammary tumor cells. Cancer Research 64, 7237-7240.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	16-April-2010 JSW
Description	Highly specific for divalent cations (Ca²⁺ > Mg²⁺ >> Sr²⁺ = Ba²⁺). More effective than antibiotic A23187 as a mobile ion carrier for Ca²⁺. Complexes with Ca²⁺ between pH 7 and 9.5, causing significant absorption in the UV range; however, in contrast to A23187 (Cat. No. 100105), it is not fluorescent. Useful for studies of Ca²⁺ transport across biological membranes and measurement of cytoplasmic free Ca²⁺. Induces apoptotic neuronal degeneration in embryonic cortical neurons. Also induces cell cycle arrest in the G₁ interval of mature Burkitt lymphoma cell lines.
Form	Waxy solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	56092-81-0
RTECS	NO0600000
Chemical formula	C₄₁H₇₂O₉
Structure formula
Purity	≥90% by HPLC
Solubility	DMSO (10 mg/ml) and Methanol (10 mg/ml)
Storage	Protect from light +2°C to +8°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 1 year at 4°C.
Toxicity	Harmful
References	Aagaard-Tillery, K.M., and Jelinek, D.F. 1995. J. Immunol. 155, 3297. Takei, N., and Endo, Y. 1994. Brain Res. 652, 65. Dupuy d’Angeac, A., et al. 1993. J. Cell Physiol. 154, 44. Lee, H.C. 1993. J. Biol. Chem. 268, 293. Kuznetsov, G., et al. 1992. J. Biol. Chem. 267, 3932. Toeplitz, B.K., et al. 1979. J. Am. Chem. Soc. 101, 3344. Liu, C.M., and Hermann, T.E. 1978. J. Biol. Chem. 253, 5892.
Citation	Jonathan Rios-Doria, et al. (2004) Cleavage of b-catenin by calpain in prostate and mammary tumor cells. Cancer Research 64, 7237-7240.

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描述

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显示价格及库存情况

产品目录编号	库存情况	包装	数量 / 包装	价格	数量
100105-10MGCN	正在查询供货情况...... — 目前缺货有货停产少量现货供货情况有待确认登录查看库存有货目前缺货有货其余：另行通知其余：另行通知另行通知联系客户服务 Contact Customer Service 联系客户服务联系客户服务	塑胶安瓿;塑胶针药瓶	10 mg	正在检索价格...... 无法检索价格。最小订购数量为倍数 Maximum Quantity is 以订单确认为准更多信息您节约了 ()。 — Request Pricing 登录查看价格	查看库存情况 —	添加到收藏夹添加到收藏夹添加到我的收藏夹
100105-1MGCN	正在查询供货情况...... — 目前缺货有货停产少量现货供货情况有待确认登录查看库存有货目前缺货有货其余：另行通知其余：另行通知另行通知联系客户服务 Contact Customer Service 联系客户服务联系客户服务	塑胶安瓿;塑胶针药瓶	1 mg	正在检索价格...... 无法检索价格。最小订购数量为倍数 Maximum Quantity is 以订单确认为准更多信息您节约了 ()。 — Request Pricing 登录查看价格	查看库存情况 —	添加到收藏夹添加到收藏夹添加到我的收藏夹
100105-5MGCN	正在查询供货情况...... — 目前缺货有货停产少量现货供货情况有待确认登录查看库存有货目前缺货有货其余：另行通知其余：另行通知另行通知联系客户服务 Contact Customer Service 联系客户服务联系客户服务	塑胶安瓿;塑胶针药瓶	5 mg	正在检索价格...... 无法检索价格。最小订购数量为倍数 Maximum Quantity is 以订单确认为准更多信息您节约了 ()。 — Request Pricing 登录查看价格	查看库存情况 —	添加到收藏夹添加到收藏夹添加到我的收藏夹

种类

Life Science Research > Inhibitors and Biochemicals > Biochemicals > Ionophores

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