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Recombinant, human soluble interleukin-6 receptor expressed in S. frugiperda insect cells. Soluble form of the IL-6 receptor that binds IL-6 and mediates IL-6 signaling through interaction with gp130. Elevated serum levels of soluble IL-6 receptors have been shown to be associated with a number of pathological states including multiple myelomas, adult T cell leukemia, interstitial lung infection, and HIV infection.
Catalogue Number
407653
Brand Family
Calbiochem®
Synonyms
rhIL-6 sR
References
References
Schobitz, B., et al. 1995. FASEB J. 9, 659. Yokoyama, A., et al. 1995. Clin. Exp. Immunol. 100, 325. Suzuki, H., et al. 1993. Eur. J. Immunol. 23, 1078. Lust, J.A., et al. 1992. Cytokine 4, 96. Sugita, T., et al. 1990. J. Exp. Med. 171, 2001. Yamasaki, K., et al. 1988. Science241, 825.
Product Information
Form
Lyophilized
Formulation
Lyophilized from sterile-filtered PBS, 50 µg BSA/µg IL-6 receptor.
ED₅₀= ≥5 ng/ml as measured by its ability to enhance IL-6-induced growth inhibition of mouse M1 myeloid leukemic cells
Purity
≥97% by SDS-PAGE
Physicochemical Information
Contaminants
Endotoxin: ≤1 EU/µg
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code
Ambient Temperature Only
Toxicity
Standard Handling
Storage
≤ -70°C
Do not freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-70°C) for long term storage or refrigerate (4°C) for short term storage. Stock solutions are stable for up to 1 month at 4°C. Avoid freeze/thaw cycles of solutions.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
产品目录编号
GTIN
407653-25UGCN
04055977211412
Documentation
Interleukin-6 Receptor, Soluble, Human, Recombinant, S. frugiperda MSDS
Interleukin-6 Receptor, Soluble, Human, Recombinant, S. frugiperda 分析证书
标题
批号
407653
参考
参考信息概述
Schobitz, B., et al. 1995. FASEB J. 9, 659. Yokoyama, A., et al. 1995. Clin. Exp. Immunol. 100, 325. Suzuki, H., et al. 1993. Eur. J. Immunol. 23, 1078. Lust, J.A., et al. 1992. Cytokine 4, 96. Sugita, T., et al. 1990. J. Exp. Med. 171, 2001. Yamasaki, K., et al. 1988. Science241, 825.
数据表
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
Revision
07-May-2010 JSW
Synonyms
rhIL-6 sR
Description
Recombinant, human soluble interleukin-6 receptor expressed in S. frugiperda insect cells. Soluble form of the IL-6 receptor that binds IL-6 and mediates IL-6 signaling through interaction with gp 130. Elevated serum levels of soluble IL-6 receptors have been shown to be associated with a number of pathological states, including multiple myelomas, adult T cell leukemia, interstitial lung infection, and HIV infection.
Form
Lyophilized
Formulation
Lyophilized from sterile-filtered PBS, 50 µg BSA/µg IL-6 receptor.
Purity
≥97% by SDS-PAGE
Contaminants
Endotoxin: ≤1 EU/µg
Biological activity
ED₅₀= ≥5 ng/ml as measured by its ability to enhance IL-6-induced growth inhibition of mouse M1 myeloid leukemic cells
Solubility
Reconstitute to a concentration ≥100 µg/ml with sterile PBS containing at least 0.1% HSA or BSA.
Storage
≤ -70°C
Do Not Freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-70°C) for long term storage or refrigerate (4°C) for short term storage. Stock solutions are stable for up to 1 month at 4°C. Avoid freeze/thaw cycles of solutions.
Toxicity
Standard Handling
References
Schobitz, B., et al. 1995. FASEB J. 9, 659. Yokoyama, A., et al. 1995. Clin. Exp. Immunol. 100, 325. Suzuki, H., et al. 1993. Eur. J. Immunol. 23, 1078. Lust, J.A., et al. 1992. Cytokine 4, 96. Sugita, T., et al. 1990. J. Exp. Med. 171, 2001. Yamasaki, K., et al. 1988. Science241, 825.
