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Recombinant, human interleukin-12 expressed in S. frugiperda insect cells. Pleiotropic cytokine that is produced by monocytes/macrophages, B cells, and connective tissue-type mast cells. Also known as natural killer cell stimulatory factor and cytotoxic lymphocyte maturation factor. A potent inducer of IFN-γ production and T cell differentiation and function.
Catalogue Number
407711
Brand Family
Calbiochem®
Synonyms
rhIL-12
References
References
Kang, K., et al. 1996. J. Immunol. 156, 1402. Riemann, H., et al. 1996. J. Immunol. 156, 1799. Brunda, M.J., et al. 1994. J. Leukoc. Biol. 55, 280. Smith, T.J., et al. 1994. Eur. J. Immunol. 24, 822. Gubler, U., et al. 1991. Proc. Natl. Acad. Sci. USA 88, 4143. Stern, A.S., et al. 1990. Proc. Natl. Acad. Sci. USA 87, 6808. Kobayashi, M., et al. 1989. J. Exp. Med. 170, 827.
Product Information
Form
Lyophilized
Formulation
Lyophilized from sterile-filtered PBS, 50 µg BSA/µg IL-12.
ED₅₀ = 50-200 pg/ml as measured by its ability to stimulate the proliferation of PHA-activated human lymphoblasts
Purity
≥95% by SDS-PAGE
Physicochemical Information
Contaminants
Endotoxin: ≤1.0 EU/µg IL-12
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code
Ambient Temperature Only
Toxicity
Standard Handling
Storage
≤ -70°C
Do not freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-70°C) for long term storage or refrigerate (4°C) for short term storage. Stock solutions are stable for up to 1 month at 4°C. Avoid freeze/thaw cycles of solutions.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
产品目录编号
GTIN
407711-5UGCN
04055977211511
Documentation
Interleukin-12, Human, Recombinant, S. frugiperda MSDS
Interleukin-12, Human, Recombinant, S. frugiperda 分析证书
标题
批号
407711
参考
参考信息概述
Kang, K., et al. 1996. J. Immunol. 156, 1402. Riemann, H., et al. 1996. J. Immunol. 156, 1799. Brunda, M.J., et al. 1994. J. Leukoc. Biol. 55, 280. Smith, T.J., et al. 1994. Eur. J. Immunol. 24, 822. Gubler, U., et al. 1991. Proc. Natl. Acad. Sci. USA 88, 4143. Stern, A.S., et al. 1990. Proc. Natl. Acad. Sci. USA 87, 6808. Kobayashi, M., et al. 1989. J. Exp. Med. 170, 827.
数据表
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
Revision
23-July-2008 RFH
Synonyms
rhIL-12
Description
Recombinant, human interleukin-12 expressed in S. frugiperda insect cells. Pleiotropic cytokine that is produced by monocytes/macrophages, B-cells, and connective tissue type mast cells. Also known as natural killer cell stimulatory factor and cytotoxic lymphocyte maturation factor. A potent inducer of IFN-γ production and T-cell differentiation and function.
Form
Lyophilized
Formulation
Lyophilized from sterile-filtered PBS, 50 µg BSA/µg IL-12.
Purity
≥95% by SDS-PAGE
Contaminants
Endotoxin: ≤1.0 EU/µg IL-12
Biological activity
ED₅₀ = 50-200 pg/ml as measured by its ability to stimulate the proliferation of PHA-activated human lymphoblasts
Solubility
Reconstitute to a concentration ≥1 µg/ml with sterile PBS containing at least 0.1% HSA or BSA.
Storage
≤ -70°C
Do Not Freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-70°C) for long term storage or refrigerate (4°C) for short term storage. Stock solutions are stable for up to 1 month at 4°C. Avoid freeze/thaw cycles of solutions.
Toxicity
Standard Handling
References
Kang, K., et al. 1996. J. Immunol. 156, 1402. Riemann, H., et al. 1996. J. Immunol. 156, 1799. Brunda, M.J., et al. 1994. J. Leukoc. Biol. 55, 280. Smith, T.J., et al. 1994. Eur. J. Immunol. 24, 822. Gubler, U., et al. 1991. Proc. Natl. Acad. Sci. USA 88, 4143. Stern, A.S., et al. 1990. Proc. Natl. Acad. Sci. USA 87, 6808. Kobayashi, M., et al. 1989. J. Exp. Med. 170, 827.
