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405268 Sigma-AldrichIndomethacin - CAS 53-86-1 - Calbiochem

A non-steroidal anti-inflammatory, cell permeable, antipyretic agent.

Indomethacin - CAS 53-86-1 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: 1-(p-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic Acid

Primary Target: COX-1

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概述

Replacement Information

重要规格表

CAS #	Empirical Formula
53-86-1	C₁₉H₁₆ClNO₄

价格及供货情况

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Description
Overview	A non-steroidal anti-inflammatory, cell permeable, antipyretic agent. Non-selective COX inhibitor (IC₅₀ = 740 nM for COX-1; IC₅₀ = 970 nM for COX-2). Inhibits phospholipase A₂(IC₅₀ = 145 µM). Strongly inhibits insoluble transthyretin (TTR) amyloid fibril formation and suppresses production of Aβ-peptide and secreted form of APP by inhibition of APP mRNA levels in NG108-15 cells.
Catalogue Number	405268
Brand Family	Calbiochem®
Synonyms	1-(p-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic Acid

References
References	Kodoyama, K., et al. 2001. Biochem. Biophys. Res. Commun. 281, 483. Weggen, S., et al. 2001. Nature 414, 212. Kalgutkar, A.S., et al. 2000. Proc. Natl. Acad. Sci. USA 97, 925. Klabunde, T., et al. 2000. Nat. Struct. Biol. 7, 312. Futaki, N., et al. 1994. Prostaglandins 47, 55. Futaki, N., et al. 1994. Prostaglandins 47, 55. Stevenson, K.M., and Lumbers, E.R. 1992. J. Dev. Physiol. 17, 257. Oliw, E. 1980. Prostaglandins 19, 271.

References

Kodoyama, K., et al. 2001. Biochem. Biophys. Res. Commun. 281, 483.
Weggen, S., et al. 2001. Nature 414, 212.
Kalgutkar, A.S., et al. 2000. Proc. Natl. Acad. Sci. USA 97, 925.
Klabunde, T., et al. 2000. Nat. Struct. Biol. 7, 312.
Futaki, N., et al. 1994. Prostaglandins 47, 55.
Futaki, N., et al. 1994. Prostaglandins 47, 55.
Stevenson, K.M., and Lumbers, E.R. 1992. J. Dev. Physiol. 17, 257.
Oliw, E. 1980. Prostaglandins 19, 271.

Product Information
CAS number	53-86-1
ATP Competitive	N
Form	White to off-white powder
Hill Formula	C₁₉H₁₆ClNO₄
Chemical formula	C₁₉H₁₆ClNO₄
Reversible	N
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	COX-1
Primary Target IC<sub>50</sub>	740 nM
Purity	≥98% by assay

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS
RTECS	NL3500000

Safety Information
R Phrase	R: 28-42/43-63 Very toxic if swallowed. May cause sensitization by inhalation and skin contact. Possible risk of harm to the unborn child.
S Phrase	S: 36/37/39-45 Wear suitable protective clothing, gloves and eye/face protection. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Highly Toxic & Carcinogenic / Teratogenic
Hazardous Materials Attention:	Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage	+15°C to +30°C
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Packaging Information

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
405268-10GMCN	04055977188493

Documentation

Indomethacin - CAS 53-86-1 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

Indomethacin - CAS 53-86-1 - Calbiochem 分析证书

标题	批号
405268	输入批号

参考

参考信息概述
Kodoyama, K., et al. 2001. Biochem. Biophys. Res. Commun. 281, 483. Weggen, S., et al. 2001. Nature 414, 212. Kalgutkar, A.S., et al. 2000. Proc. Natl. Acad. Sci. USA 97, 925. Klabunde, T., et al. 2000. Nat. Struct. Biol. 7, 312. Futaki, N., et al. 1994. Prostaglandins 47, 55. Futaki, N., et al. 1994. Prostaglandins 47, 55. Stevenson, K.M., and Lumbers, E.R. 1992. J. Dev. Physiol. 17, 257. Oliw, E. 1980. Prostaglandins 19, 271.

参考信息概述

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	13-May-2008 RFH
Synonyms	1-(p-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic Acid
Description	A cell-permeable, non-steroidal anti-inflammatory, anti-pyretic agent. Non-selective cyclooxygenase (COX) inhibitor (IC₅₀ = 740 nM for COX-1; IC₅₀ = 970 nM for COX-2). Inhibits phospholipase A₂ (IC₅₀ = 145 µM). Reported to reduce Aβ₄₂ levels independently of COX activity.
Form	White to off-white powder
CAS number	53-86-1
RTECS	NL3500000
Chemical formula	C₁₉H₁₆ClNO₄
Structure formula
Purity	≥98% by assay
Solubility	Ethanol (20 mg/ml)
Storage	+15°C to +30°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity	Highly Toxic & Carcinogenic / Teratogenic
Merck USA index	14, 4968
References	Kodoyama, K., et al. 2001. Biochem. Biophys. Res. Commun. 281, 483. Weggen, S., et al. 2001. Nature 414, 212. Kalgutkar, A.S., et al. 2000. Proc. Natl. Acad. Sci. USA 97, 925. Klabunde, T., et al. 2000. Nat. Struct. Biol. 7, 312. Futaki, N., et al. 1994. Prostaglandins 47, 55. Futaki, N., et al. 1994. Prostaglandins 47, 55. Stevenson, K.M., and Lumbers, E.R. 1992. J. Dev. Physiol. 17, 257. Oliw, E. 1980. Prostaglandins 19, 271.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Lipid Signaling Inhibitors > Cyclooxygenase (COX) Inhibitors

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