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			96-Well Plate

数量	产品目录编号	订购说明	数量 / 包装	公开价
	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

324519 Sigma-AldrichInSolution™ eIF4E/eIF4G Interaction Inhibitor, 4EGI-1 - CAS 315706-13-9 - Calbiochem

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

分析证书
参考
Data Sheet

同义词: 2-((4-(3,4-Dichlorophenyl)-thiazol-2-ylhydrazono)-3-(2-nitrophenyl))propionic acid, eIF4F Inhibitor I

Primary Target: eIF4E

Recommended Products

概述

Replacement Information

重要规格表

CAS #	Empirical Formula
315706-13-9	C₁₈H₁₂Cl₂N₄O₄S

价格及供货情况

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Description
Overview	A cell-permeable hydrazone compound that reversibly binds eukaryotic translation initiation factor 4E (eIF4E; K_D = 25 µM) and disrupts eIF4E/eIF4G, but not eIF4E/4E-BP1, complex formation. Reported to downregulate the protein, but not mRNA, levels of c-Myc and Bcl-x_L in Jurkat cells (8 hrs), leading to apoptotic cell death after prolonged exposure (24 hrs, IC₅₀ ~25 µM). Shown to be brain permeant and reduce neuroligin protein levels, and restore L-LTP threshold and rescue autistic-like behaviours in Eif4ebp2 knockout mice.
Catalogue Number	324519
Brand Family	Calbiochem®
Synonyms	2-((4-(3,4-Dichlorophenyl)-thiazol-2-ylhydrazono)-3-(2-nitrophenyl))propionic acid, eIF4F Inhibitor I

References
References	Gkogkas, C.G., et al. 2012. Nature 493, 371. Moerke, N. J., et al. 2007. Cell 128, 257.

Product Information
CAS number	315706-13-9
Form	Liquid
Formulation	A 25 mM (5 mg/443 µL) solution of eIF4E/eIF4G Interaction Inhibitor, 4EGI-1 (Cat. No. 324517)
Hill Formula	C₁₈H₁₂Cl₂N₄O₄S
Chemical formula	C₁₈H₁₂Cl₂N₄O₄S
Hygroscopic	Hygroscopic
Reversible	Y
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	eIF4E
Primary Target K<sub>i</sub>	25 µ
Purity	≥95% by HPLC (sum of two isomers)

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information
R Phrase	R: 36/38 Irritating to eyes and skin.
S Phrase	S: 26-36 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing.

Product Usage Statements

Storage and Shipping Information
Ship Code	Dry Ice Only
Toxicity	Irritant
Storage	≤ -70°C
Protect from Light	Protect from light
Hygroscopic	Hygroscopic
Avoid freeze/thaw	Avoid freeze/thaw
Do not freeze	Ok to freeze
Special Instructions	Following initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 6 months at -70°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
324519-5MGCN	04055977197341

Documentation

InSolution™ eIF4E/eIF4G Interaction Inhibitor, 4EGI-1 - CAS 315706-13-9 - Calbiochem 分析证书

标题	批号
324519	输入批号

参考

参考信息概述
Gkogkas, C.G., et al. 2012. Nature 493, 371. Moerke, N. J., et al. 2007. Cell 128, 257.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	22-February-2013 JSW
Synonyms	2-((4-(3,4-Dichlorophenyl)-thiazol-2-ylhydrazono)-3-(2-nitrophenyl))propionic acid, eIF4F Inhibitor I
Description	A cell-permeable hydrazone compound that reversibly binds eukaryotic translation initiation factor 4E (eIF4E; K_D = 25 µM) and disrupts eIF4E/eIF4G, but not eIF4E/4E-BP1, complex formation. Reported to downregulate the protein, but not mRNA, levels of c-Myc and Bcl-x_L in Jurkat cells (8 hrs), leading to apoptotic cell death after prolonged exposure (24 hrs, IC₅₀ ~25 µM). Shown to be brain permeant and reduce neuroligin protein levels, and restore L-LTP threshold and rescue autistic-like behaviours in Eif4ebp2 knockout mice.
Form	Liquid
Formulation	A 25 mM (5 mg/443 µL) solution of eIF4E/eIF4G Interaction Inhibitor, 4EGI-1 (Cat. No. 324517)
Intert gas (Yes/No)	Packaged under inert gas
CAS number	315706-13-9
Chemical formula	C₁₈H₁₂Cl₂N₄O₄S
Structure formula
Purity	≥95% by HPLC (sum of two isomers)
Storage	Protect from light Avoid freeze/thaw ≤ -70°C Hygroscopic
Do Not Freeze	Ok to freeze
Special Instructions	Following initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 6 months at -70°C.
Toxicity	Irritant
References	Gkogkas, C.G., et al. 2012. Nature 493, 371. Moerke, N. J., et al. 2007. Cell 128, 257.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Other Inhibitors of Biological Interest > Translational Initiation Inhibitors

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