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			96-Well Plate

数量	产品目录编号	订购说明	数量 / 包装	公开价
	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

681676 Sigma-AldrichInSolution™ Wortmannin - Calbiochem

Wortmannin is a fungal metabolite that acts as a potent, selective, cell-permeable and irreversible inhibitor of phosphatidylinositol 3-kinase (PI 3-kinase).

InSolution™ Wortmannin - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: MLCK Inhibitor II

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概述

Replacement Information

重要规格表

Empirical Formula
C₂₃H₂₄O₈

价格及供货情况

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Description
Catalogue Number	681676
Brand Family	Calbiochem®
Synonyms	MLCK Inhibitor II
Application Data

References
References	Cross, M.J., et al. 1995. J. Biol. Chem. 270, 25352. Nakamura, I., et al. 1995. FEBS Lett. 361, 79. Ferby, I.M., et al. 1994. J. Biol. Chem. 269, 30485. Okada, T., et al. 1994. J. Biol. Chem. 269, 3568. Wymann, M.P. and Arcaro, A. 1994. Biochem. J. 298, 517. Arcaro, A. and Wymann, M.P. 1993. Biochem. J. 296, 297. Nakanishi, S., et al. 1992. J. Biol. Chem. 267, 2157. Bonser, R.W., et al. 1991. Br. J. Pharmacol. 103, 1237.

References

Cross, M.J., et al. 1995. J. Biol. Chem. 270, 25352.
Nakamura, I., et al. 1995. FEBS Lett. 361, 79.
Ferby, I.M., et al. 1994. J. Biol. Chem. 269, 30485.
Okada, T., et al. 1994. J. Biol. Chem. 269, 3568.
Wymann, M.P. and Arcaro, A. 1994. Biochem. J. 298, 517.
Arcaro, A. and Wymann, M.P. 1993. Biochem. J. 296, 297.
Nakanishi, S., et al. 1992. J. Biol. Chem. 267, 2157.
Bonser, R.W., et al. 1991. Br. J. Pharmacol. 103, 1237.

Product Information
Form	Liquid
Formulation	A 10 mM (1 mg/233 µl) solution of Wortmannin (Cat. No. 681675) in DMSO.
Hill Formula	C₂₃H₂₄O₈
Chemical formula	C₂₃H₂₄O₈
Hygroscopic	Hygroscopic
Quality Level	MQ100

Applications

Biological Information
Purity	≥95% by HPLC

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information
R Phrase	R: 21/22-36/38 Harmful in contact with skin and if swallowed. Irritating to eyes and skin.
S Phrase	S: 24-26-36/37/39-45 Avoid contact with skin. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing, gloves and eye/face protection. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).

Product Usage Statements

Storage and Shipping Information
Ship Code	Shipped with Blue Ice or with Dry Ice
Toxicity	Harmful
Storage	-20°C
Protect from Light	Protect from light
Hygroscopic	Hygroscopic
Do not freeze	Ok to freeze
Special Instructions	Following initial thaw, aliquot and freeze (-20°C).

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
681676-1MGCN	04055977225242

Documentation

InSolution™ Wortmannin - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

InSolution™ Wortmannin - Calbiochem 分析证书

标题	批号
681676	输入批号

参考

参考信息概述
Cross, M.J., et al. 1995. J. Biol. Chem. 270, 25352. Nakamura, I., et al. 1995. FEBS Lett. 361, 79. Ferby, I.M., et al. 1994. J. Biol. Chem. 269, 30485. Okada, T., et al. 1994. J. Biol. Chem. 269, 3568. Wymann, M.P. and Arcaro, A. 1994. Biochem. J. 298, 517. Arcaro, A. and Wymann, M.P. 1993. Biochem. J. 296, 297. Nakanishi, S., et al. 1992. J. Biol. Chem. 267, 2157. Bonser, R.W., et al. 1991. Br. J. Pharmacol. 103, 1237.

参考信息概述

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	03-November-2008 JSW
Synonyms	MLCK Inhibitor II
Application Data
Description	A fungal metabolite that acts as a potent, selective, cell-permeable and irreversible inhibitor of phosphatidylinositol 3-kinase (PI 3-kinase) in purified preparations and cytosolic fractions (IC₅₀ = 5 nM). Preincubation of fibroblasts with wortmannin abolishes PDGF-mediated Ins(3,4,5)P₃ formation (IC₅₀ = 5 nM). Blocks the catalytic activity of PI 3-kinase without affecting the upstream signaling events. Also blocks the metabolic effects of insulin in isolated rat adipocytes without affecting the insulin receptor tyrosine kinase activity. Inhibits MAP kinase activation induced by platelet activating factor in guinea pig neutrophils (0.2-0.3 µM). Inhibits osteoclastic bone resorption. Inhibits other kinases, such as myosin light chain kinase (IC₅₀ = 200 nM) and PI 4-kinase at concentrations 100-fold higher than that required for the inhibition of PI 3-kinase. Also blocks phospholipase D.
Form	Liquid
Formulation	A 10 mM (1 mg/233 µl) solution of Wortmannin (Cat. No. 681675) in DMSO.
Intert gas (Yes/No)	Packaged under inert gas
Chemical formula	C₂₃H₂₄O₈
Purity	≥95% by HPLC
Storage	Protect from light -20°C Hygroscopic
Do Not Freeze	Ok to freeze
Special Instructions	Following initial thaw, aliquot and freeze (-20°C).
Toxicity	Harmful
Merck USA index	14, 10053
References	Cross, M.J., et al. 1995. J. Biol. Chem. 270, 25352. Nakamura, I., et al. 1995. FEBS Lett. 361, 79. Ferby, I.M., et al. 1994. J. Biol. Chem. 269, 30485. Okada, T., et al. 1994. J. Biol. Chem. 269, 3568. Wymann, M.P. and Arcaro, A. 1994. Biochem. J. 298, 517. Arcaro, A. and Wymann, M.P. 1993. Biochem. J. 296, 297. Nakanishi, S., et al. 1992. J. Biol. Chem. 267, 2157. Bonser, R.W., et al. 1991. Br. J. Pharmacol. 103, 1237.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Phosphatidylinositol 3-Kinase (PI 3-kinase) Inhibitors

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