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A potent competitive inhibitor of cytidine deaminase. Used in combination with cytosine arabinoside (Ara-C) to assess the anti-leukemic activity and anti-tumor activity of Ara-C in in vitro studies. The solid form of this compound (Cat. No. 584222) is also available.
InSolution™ Tetrahydrouridine - CAS 18771-50-1 - Calbiochem 分析证书
标题
批号
584223
参考
参考信息概述
Yusa, K., et al. 1995. Biochem. Biophys. Res. Commun.206, 486. Bouffard, D.Y., et al. 1993. Biochem Pharmacol.45, 1857. Laliberte, J., et al. 1992. Cancer Chemotherap. Pharmacol.30, 7. Riva, C., et al. 1992. Chemotherapy38, 358. Yusa, K., et al. 1992. J. Biol. Chem.267, 16848. Hanze, A.R. 1967. J. Am. Chem. Soc.89, 6720.
数据表
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
A potent competitive inhibitor of cytidine deaminase. Used in combination with cytosine arabinoside (Ara-C) to assess the anti-leukemic activity and anti-tumor activity of Ara-C in in vitro studies. The solid form of this compound (Cat. No. 584222) is also available.
Form
Liquid
Formulation
A 100 mM (25 mg/879 µL) solution of Tetrahydrouridine (Cat. No. 584222) in H₂O.
Intert gas (Yes/No)
Packaged under inert gas
CAS number
18771-50-1
Structure formula
Purity
≥90% by TLC
Storage
Protect from light
Avoid freeze/thaw
≤ -70°C
Do Not Freeze
Ok to freeze
Special Instructions
Following initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 6 months at -70°C.
Toxicity
Standard Handling
References
Yusa, K., et al. 1995. Biochem. Biophys. Res. Commun.206, 486. Bouffard, D.Y., et al. 1993. Biochem Pharmacol.45, 1857. Laliberte, J., et al. 1992. Cancer Chemotherap. Pharmacol.30, 7. Riva, C., et al. 1992. Chemotherapy38, 358. Yusa, K., et al. 1992. J. Biol. Chem.267, 16848. Hanze, A.R. 1967. J. Am. Chem. Soc.89, 6720.
