数量	产品目录编号	订购说明	数量 / 包装	公开价
			96-Well Plate

数量	产品目录编号	订购说明	数量 / 包装	公开价
	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

566321 Sigma-AldrichInSolution™ Sirtinol - Calbiochem

InSolution™ Sirtinol - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
数据表
Data Sheet

同义词: 2-[(2-Hydroxynaphthalen-1-ylmethylene)amino]-N-(1-phenethyl)benzamide, Sir Two Inhibitor Naphthol, SIRT1 Inhibitor I, SIRT1/2 Inhibitor I, SIRT2 Inhibitor III

Primary Target: ySir2

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概述

Replacement Information

重要规格表

Empirical Formula
C₂₆H₂₂N₂O₂

价格及供货情况

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Description
Catalogue Number	566321
Brand Family	Calbiochem®
Synonyms	2-[(2-Hydroxynaphthalen-1-ylmethylene)amino]-N-(1-phenethyl)benzamide, Sir Two Inhibitor Naphthol, SIRT1 Inhibitor I, SIRT1/2 Inhibitor I, SIRT2 Inhibitor III

References
References	Mai, A., et al. 2005. J. Med. Chem. 48, 7789. Grozinger, C.M., et al. 2001. J. Biol. Chem. 276, 38837.

Product Information
ATP Competitive	N
Form	Liquid
Formulation	A 10 mM (1 mg/254 µl) solution of Sirtinol (Cat. No. 566320) in DMSO.
Hill Formula	C₂₆H₂₂N₂O₂
Chemical formula	C₂₆H₂₂N₂O₂
Hygroscopic	Hygroscopic
Reversible	N
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	ySir2
Primary Target IC<sub>50</sub>	48 µM, 131 µM and 58 µM for ySir2, hSIRT1 and hSIRT2, respectively
Purity	≥97% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Shipped with Blue Ice or with Dry Ice
Toxicity	Irritant
Storage	+2°C to +8°C
Protect from Light	Protect from light
Hygroscopic	Hygroscopic
Do not freeze	Ok to freeze
Special Instructions	Following initial thaw, aliquot and refrigerate (4°C).

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
566321-1MGCN	04055977191387

Documentation

InSolution™ Sirtinol - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

InSolution™ Sirtinol - Calbiochem 分析证书

标题	批号
566321	输入批号

参考

参考信息概述
Mai, A., et al. 2005. J. Med. Chem. 48, 7789. Grozinger, C.M., et al. 2001. J. Biol. Chem. 276, 38837.

数据表

标题
SIRTainty™ Class III HDAC Assay

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	01-October-2007 JSW
Synonyms	2-[(2-Hydroxynaphthalen-1-ylmethylene)amino]-N-(1-phenethyl)benzamide, Sir Two Inhibitor Naphthol, SIRT1 Inhibitor I, SIRT1/2 Inhibitor I, SIRT2 Inhibitor III
Description	A cell-permeable 2-hydroxy-1-napthaldehyde derivative that acts as a specific and a direct inhibitor of sirtuin class of histone deacetylase (HDAC) activity. Does not affect human HDAC1. Reported to block Sir2p transcriptional silencing activity in vivo (IC₅₀ = 25 µM) and NAD-dependent HDAC activity in purified recombinant yeast Sir2p and human SIRT2 in vitro (IC₅₀ = 68 µM and 38 µM, respectively).
Form	Liquid
Formulation	A 10 mM (1 mg/254 µl) solution of Sirtinol (Cat. No. 566320) in DMSO.
Intert gas (Yes/No)	Packaged under inert gas
Chemical formula	C₂₆H₂₂N₂O₂
Structure formula
Purity	≥97% by HPLC
Storage	Protect from light +2°C to +8°C Hygroscopic
Do Not Freeze	Ok to freeze
Special Instructions	Following initial thaw, aliquot and refrigerate (4°C).
Toxicity	Irritant
References	Mai, A., et al. 2005. J. Med. Chem. 48, 7789. Grozinger, C.M., et al. 2001. J. Biol. Chem. 276, 38837.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Cell Cycle/Cell Division > Histone Acetylase and Deacetylase Inhibitors

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