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			96-Well Plate

数量	产品目录编号	订购说明	数量 / 包装	公开价
	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

565771 Sigma-AldrichInSolution™ γ-Secretase Inhibitor X - Calbiochem

InSolution™ γ-Secretase Inhibitor X is a 1 mM solution in DMSO. A highly potent inhibitor of g-secretase (IC₅₀ = 17, 48, 67 nM for Aβtotal, Aβ40 & Aβ42 in SHSY5Y cells overexpressing spβA4CTF).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: L-685,458, {1S-Benzyl-4R-[1-(1S-carbamoyl-2-phenethylcarbamoyl)-1S-3-methylbutylcarbamoyl]-2R-hydroxy-5-phenylpentyl}carbamic Acid tert-butyl Ester

Primary Target: Aβ_total

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概述

Replacement Information

重要规格表

Empirical Formula
C₃₉H₅₂N₄O₆

价格及供货情况

产品目录编号	库存情况	包装	数量 / 包装	价格	数量
565771-250UGCN	正在查询供货情况...... — 目前缺货有货停产少量现货供货情况有待确认登录查看库存有货目前缺货有货其余：另行通知其余：另行通知另行通知联系客户服务 Contact Customer Service 联系客户服务联系客户服务	塑胶安瓿;塑胶针药瓶	250 μg	正在检索价格...... 无法检索价格。最小订购数量为倍数 Maximum Quantity is 以订单确认为准更多信息您节约了 ()。 — Request Pricing 登录查看价格	查看库存情况 —	添加到收藏夹添加到收藏夹添加到我的收藏夹
565771-500UGCN	正在查询供货情况...... — 目前缺货有货停产少量现货供货情况有待确认登录查看库存有货目前缺货有货其余：另行通知其余：另行通知另行通知联系客户服务 Contact Customer Service 联系客户服务联系客户服务	塑胶安瓿;塑胶针药瓶	500 μg	正在检索价格...... 无法检索价格。最小订购数量为倍数 Maximum Quantity is 以订单确认为准更多信息您节约了 ()。 — Request Pricing 登录查看价格	查看库存情况 —	添加到收藏夹添加到收藏夹添加到我的收藏夹

Description
Overview	A cell-permeable hydroxyethylene dipeptide isostere that acts as a highly specific and a potent inhibitor of γ-secretase (Aβ_total IC₅₀ = 17 nM, Aβ₄₀ IC₅₀ = 48 nM, and Aβ₄₂ IC₅₀ = 67 nM in SHSY5Y cells overexpressing spβA4CTF). Binds to presenilin and blocks Notch intracellular domain production. Functions as a transition state analog mimic at the catalytic site of an aspartyl protease, however, it exhibits over 100-fold greater selectivity for γ-secretase than for cathepsin D.
Catalogue Number	565771
Brand Family	Calbiochem®
Synonyms	L-685,458, {1S-Benzyl-4R-[1-(1S-carbamoyl-2-phenethylcarbamoyl)-1S-3-methylbutylcarbamoyl]-2R-hydroxy-5-phenylpentyl}carbamic Acid tert-butyl Ester

References
References	Weidemann, A., et al. 2002. Biochemistry 41, 2825. Doerfler, P., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 9312. Li, Y.M., et al. 2000. Proc. Natl. Acad. Sci. USA 97, 6138. Shearman, M.S., et al. 2000. Biochemistry 39, 8698.

Product Information
ATP Competitive	N
Form	Liquid
Formulation	A 1 mM (250 µg in 372 µl or 500 µg in 744 µl) solution in DMSO.
Hill Formula	C₃₉H₅₂N₄O₆
Chemical formula	C₃₉H₅₂N₄O₆
Reversible	N
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	Aβ_total
Primary Target IC<sub>50</sub>	Aβtotal 17 nM, Aβ40 48 nM, and Aβ42 67 nM in SHSY5Y cells overexpressing spβA4CTF
Purity	≥90% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	-20°C
Protect from Light	Protect from light
Protect from Moisture	Protect from moisture
Do not freeze	Ok to freeze
Special Instructions	Following initial thaw, aliquot and freeze (-20°C).

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
565771-250UGCN	04055977267839
565771-500UGCN	04055977267846

Documentation

InSolution™ γ-Secretase Inhibitor X - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

InSolution™ γ-Secretase Inhibitor X - Calbiochem 分析证书

标题	批号
565771	输入批号

参考

参考信息概述
Weidemann, A., et al. 2002. Biochemistry 41, 2825. Doerfler, P., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 9312. Li, Y.M., et al. 2000. Proc. Natl. Acad. Sci. USA 97, 6138. Shearman, M.S., et al. 2000. Biochemistry 39, 8698.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	10-September-2008 RFH
Synonyms	L-685,458, {1S-Benzyl-4R-[1-(1S-carbamoyl-2-phenethylcarbamoyl)-1S-3-methylbutylcarbamoyl]-2R-hydroxy-5-phenylpentyl}carbamic Acid tert-butyl Ester
Description	A cell-permeable hydroxyethylene dipeptide isostere that acts as a potent and highly specific inhibitor of γ-secretase (Aβ total IC₅₀ = 17 nM; Aβ₄₀ IC₅₀ = 48 nM; and Aβ₄₂ IC₅₀ = 67 nM in SH-SY5Y cells overexpressing spβA4CTF). Binds to presenilin and blocks Notch intracellular domain production. Also reported to block the formation of εCTF, resulting in the accumulation of α- and βCTF. Functions as a transition state analog mimic at the catalytic site of an aspartyl protease, however, it exhibits over 100-fold greater selectivity for γ-secretase than for cathepsin D.
Form	Liquid
Formulation	A 1 mM (250 µg in 372 µl or 500 µg in 744 µl) solution in DMSO.
Intert gas (Yes/No)	Packaged under inert gas
Chemical formula	C₃₉H₅₂N₄O₆
Structure formula
Purity	≥90% by HPLC
Storage	Protect from moisture Protect from light -20°C
Do Not Freeze	Ok to freeze
Special Instructions	Following initial thaw, aliquot and freeze (-20°C).
Toxicity	Standard Handling
References	Weidemann, A., et al. 2002. Biochemistry 41, 2825. Doerfler, P., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 9312. Li, Y.M., et al. 2000. Proc. Natl. Acad. Sci. USA 97, 6138. Shearman, M.S., et al. 2000. Biochemistry 39, 8698.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Neurobiology / Neurodegeneration > Secretase Inhibitors

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