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			96-Well Plate

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	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

565784 Sigma-AldrichInSolution™ γ-Secretase Inhibitor IX - Calbiochem

InSolution™ g-Secretase Inhibitor IX, CAS 208255-80-5, is a 25 mM (5 mg/462 µl or 10 mg/924 µl) solution of g-secretase Inhibitor IX (DAPT; Cat. No. 565770) in DMSO.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet
Citations

同义词: N-[N-(3,5-Difluorophenacetyl-L-alanyl)]-S-phenylglycine t-Butyl Ester, DAPT

Primary Target: Aβ_total

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概述

Replacement Information

重要规格表

Empirical Formula
C₂₃H₂₆F₂N₂O₄

价格及供货情况

产品目录编号	库存情况	包装	数量 / 包装	价格	数量
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Description
Catalogue Number	565784
Brand Family	Calbiochem®
Synonyms	N-[N-(3,5-Difluorophenacetyl-L-alanyl)]-S-phenylglycine t-Butyl Ester, DAPT

References
References	Oddo, S., et al. 2004. Neuron 43, 321. Dovey, H.F., et al. 2001. J. Neurochem. 76, 173. Vandermeeren, M., et al. 2001. Neurosci. Lett. 315, 145.

Product Information
ATP Competitive	N
Form	Clear colorless liquid
Formulation	A 25 mM (5 mg/462 µl or 10 mg/924 µl) solution of γ-Secretase Inhibitor IX (Cat. No. 565770) in DMSO.
Hill Formula	C₂₃H₂₆F₂N₂O₄
Chemical formula	C₂₃H₂₆F₂N₂O₄
Hygroscopic	Hygroscopic
Reversible	N
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	Aβ_total
Primary Target IC<sub>50</sub>	115 nM, 200 nM against Aβ_total, Aβ42, respectively
Purity	≥95% by HPLC

Physicochemical Information
Cell permeable	N

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Shipped with Blue Ice or with Dry Ice
Toxicity	Irritant
Storage	+2°C to +8°C
Protect from Light	Protect from light
Hygroscopic	Hygroscopic
Do not freeze	Ok to freeze
Special Instructions	Following initial use, aliquot and freeze (-20°C).

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
565784-10MGCN	04055977267303
565784-5MGCN	04055977191806

Documentation

InSolution™ γ-Secretase Inhibitor IX - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

InSolution™ γ-Secretase Inhibitor IX - Calbiochem 分析证书

标题	批号
565784	输入批号

参考

参考信息概述
Oddo, S., et al. 2004. Neuron 43, 321. Dovey, H.F., et al. 2001. J. Neurochem. 76, 173. Vandermeeren, M., et al. 2001. Neurosci. Lett. 315, 145.

引用

标题

Yunzhou Dong, et al. (2006) Calpain inhibitor MDL28170 modulates Aβ formation by inhibiting the formation of intermediate Aβ46 and protecting Aβ from degradation. FASEB Journal in press,.

Yasuhiko Kawakami, et al. (2005) Retinoic acid signalling links leftright asymmetric patterning and bilaterally symmetric somitogenesis in the zebrafish embryo. Nature 435, 165-171.

Aurelie Olivier, et al. (2005) The Notch ligand delta-1 is a hematopoietic development co- factor for plasmacytoid dendritic cells. Blood 107, 2694-2701.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	28-January-2013 JSW
Synonyms	N-[N-(3,5-Difluorophenacetyl-L-alanyl)]-S-phenylglycine t-Butyl Ester, DAPT
Description	A cell-permeable dipeptide that inhibits γ-secretase activity and suppresses Aβ production (Aβ total IC₅₀ = 115 nM; Aβ₄₂ IC₅₀ = 200 nM). Reported to be functionally active in both HEK293 cells overexpressing human APP751 and neuronal cultures, however, it does not affect the secretion of amyloid-b precursor protein (APP). Effective in acutely lowering Ab in APPV717F-transgenic mice. Also effective in inhibiting the production of a ~6 kDa C-terminal cleavage product (CTFg) in HEK293 cells stably transfected with the Swedish mutant, βAPP₆₉₅. Reported to reduce extracellular Aβ plaques and intracellular Aβ accumulation in 3xTgAD transgenic mice.
Form	Clear colorless liquid
Formulation	A 25 mM (5 mg/462 µl or 10 mg/924 µl) solution of γ-Secretase Inhibitor IX (Cat. No. 565770) in DMSO.
Intert gas (Yes/No)	Packaged under inert gas
Chemical formula	C₂₃H₂₆F₂N₂O₄
Structure formula
Purity	≥95% by HPLC
Storage	Protect from light +2°C to +8°C Hygroscopic
Do Not Freeze	Ok to freeze
Special Instructions	Following initial use, aliquot and freeze (-20°C).
Toxicity	Irritant
References	Oddo, S., et al. 2004. Neuron 43, 321. Dovey, H.F., et al. 2001. J. Neurochem. 76, 173. Vandermeeren, M., et al. 2001. Neurosci. Lett. 315, 145.
Citation	Yunzhou Dong, et al. (2006) Calpain inhibitor MDL28170 modulates Aβ formation by inhibiting the formation of intermediate Aβ46 and protecting Aβ from degradation. FASEB Journal in press,. Yasuhiko Kawakami, et al. (2005) Retinoic acid signalling links leftright asymmetric patterning and bilaterally symmetric somitogenesis in the zebrafish embryo. Nature 435, 165-171. Aurelie Olivier, et al. (2005) The Notch ligand delta-1 is a hematopoietic development co- factor for plasmacytoid dendritic cells. Blood 107, 2694-2701.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Neurobiology / Neurodegeneration > Secretase Inhibitors

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