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			96-Well Plate

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	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

559398 Sigma-AldrichInSolution™ SB 203580 - Calbiochem

InSolution SB 203580, CAS 152121-47-6, is a 1 mg/ml solution of SB 203580 in DMSO. A cell-permeable, selective, reversible inhibitor of p38 MAP kinase (IC₅₀ = 34 nM in vitro, 600 nM in cells).

InSolution™ SB 203580 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet
Citations

同义词: InSolution™ p38 MAP Kinase Inhibitor XVI

Primary Target: P38MAPK

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概述

Replacement Information

重要规格表

Empirical Formula
C₂₁H₁₆FN₃OS

价格及供货情况

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Description
Catalogue Number	559398
Brand Family	Calbiochem®
Synonyms	InSolution™ p38 MAP Kinase Inhibitor XVI

References
References	Powell, D.J., et al. 2003. Mol. Cell Biol. 23, 7794. Davies, S.P., et al. 2000. Biochem. J. 351, 95. Iwasaki, S., et al. 1999. J. Biol. Chem. 274, 26503. Gallagher, T.F., et al. 1997. Bioorg. Med. Chem. 5, 49. LoGrasso, P.V., et al. 1997. Biochem. 36, 10422. Hazzalin, C.A., et al. 1996. Curr. Biol. 6, 1028. Kramer, R.M., et al. 1996. J. Biol. Chem. 271, 27723. Saklatvala, J., et al. 1996. J. Biol. Chem. 271, 6586. Cuenda, A., et al. 1995. FEBS Lett. 364, 229. Gallagher, T.F., et al. 1995. Bioorg. Med. Chem. Lett. 5, 1171. Lee, J.C., et al. 1994. Nature 372, 739.

References

Powell, D.J., et al. 2003. Mol. Cell Biol. 23, 7794.
Davies, S.P., et al. 2000. Biochem. J. 351, 95.
Iwasaki, S., et al. 1999. J. Biol. Chem. 274, 26503.
Gallagher, T.F., et al. 1997. Bioorg. Med. Chem. 5, 49.
LoGrasso, P.V., et al. 1997. Biochem. 36, 10422.
Hazzalin, C.A., et al. 1996. Curr. Biol. 6, 1028.
Kramer, R.M., et al. 1996. J. Biol. Chem. 271, 27723.
Saklatvala, J., et al. 1996. J. Biol. Chem. 271, 6586.
Cuenda, A., et al. 1995. FEBS Lett. 364, 229.
Gallagher, T.F., et al. 1995. Bioorg. Med. Chem. Lett. 5, 1171.
Lee, J.C., et al. 1994. Nature 372, 739.

Product Information
ATP Competitive	Y
Form	Liquid
Formulation	A 1 mg/ml solution of SB 203580 (Cat. No. 559389) in anhydrous DMSO.
Hill Formula	C₂₁H₁₆FN₃OS
Chemical formula	C₂₁H₁₆FN₃OS
Reversible	Y
Structure formula Image
Quality Level	MQ100

Applications
Application	InSolution SB 203580, CAS 152121-47-6, is a 1 mg/ml solution of SB 203580 in DMSO. A cell-permeable, selective, reversible inhibitor of p38 MAP kinase (IC₅₀ = 34 nM in vitro, 600 nM in cells).

Biological Information
Primary Target	P38MAPK
Primary Target IC<sub>50</sub>	34 nM in vitro, 600 nM in cells against p38 MAPK; 50-100 nM Inhibiting IL-1 and TNF-α production from LPS-stimulated human monocytes and the human monocyte cell line THP-1; 0.2-1.0 µM inhibiting platelet aggregation by collagen
Purity	≥98% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information
R Phrase	R: 36/38 Irritating to eyes and skin.
S Phrase	S: 24/25-26 Avoid contact with skin and eyes. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.

Product Usage Statements

Storage and Shipping Information
Ship Code	Blue Ice Only
Toxicity	Irritant
Storage	-20°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following initial thaw, aliquot, purge with inert gas, and freeze (-20°C).

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
559398-1MLCN	04055977192636

Documentation

InSolution™ SB 203580 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

InSolution™ SB 203580 - Calbiochem 分析证书

标题	批号
559398	输入批号

参考

参考信息概述
Powell, D.J., et al. 2003. Mol. Cell Biol. 23, 7794. Davies, S.P., et al. 2000. Biochem. J. 351, 95. Iwasaki, S., et al. 1999. J. Biol. Chem. 274, 26503. Gallagher, T.F., et al. 1997. Bioorg. Med. Chem. 5, 49. LoGrasso, P.V., et al. 1997. Biochem. 36, 10422. Hazzalin, C.A., et al. 1996. Curr. Biol. 6, 1028. Kramer, R.M., et al. 1996. J. Biol. Chem. 271, 27723. Saklatvala, J., et al. 1996. J. Biol. Chem. 271, 6586. Cuenda, A., et al. 1995. FEBS Lett. 364, 229. Gallagher, T.F., et al. 1995. Bioorg. Med. Chem. Lett. 5, 1171. Lee, J.C., et al. 1994. Nature 372, 739.

参考信息概述

引用

标题

Alexandra Thiel, et al. (2006) Expression of Cyclooxygenase-2 Is Regulated by Glycogen Synthase Kinase-3beta in Gastric Cancer Cells. Journal of Biological Chemistry 281, 4564-4569.

Bysani Chandrasekar, et al. (2005) The pro-atherogenic cytokine interleukin-18 induces CXCL16 expression in rat aortic smooth muscle cells via MyD88, interleukin-1 receptor-associated kinase, tumor necrosis factor receptor-associated factor 6, c-Src, phosphatidylinositol 3-kinase, Akt, c-J. Journal of Biological Chemistry 280, 26263-26277.

Guadalupe Sabio, et al. (2005) p38γ regulates the localisation of SAP97 in the cytoskeleton by modulating its interaction with GKAP. The EMBO Journal 24, 1134-1145.

Jose G. Trevino, et al. (2005) Expression and activity of Src regulate interleukin-8 expression in pancreatic adenocarcinoma cells: implications for angiogenesis. Cancer Research 65, 7214-7222.

Wojciech Wojciechowski, et al. (2005) Enhanced Expression of CD20 in Human Tumor B Cells is Controlled Through ERK-Dependent Mechanisms. Journal of Immunology 174, 7859-7868.

Yung-Luen Yu, et al. (2005) MAP kinase-mediated phosphorylation of GATA-1 promotes Bcl-XL expression and cell survival. Journal of Biological Chemistry 280, 29533-29542.

Naoto Inukai, et al. (2004) A novel hydrogen peroxide-induced phosphorylation and ubiquitination pathway leading to RNA polymerase II proteolysis. Journal of Biological Chemistry 279, 8190-8195.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	05-October-2007 RFH
Synonyms	InSolution™ p38 MAP Kinase Inhibitor XVI
Description	A highly specific, cell-permeable inhibitor of p38 kinase (IC₅₀ = 34 nM in vitro, 600 nM in cells). Also known as reactivating kinase (RK) and CSBP (cytokine synthesis anti-inflammatory drug binding protein). Does not significantly inhibit JNK or p42 MAP kinase even at 100 µM. Inhibits IL-1 and TNF-α production from LPS-stimulated human monocytes and the human monocyte cell line THP-1 (IC₅₀ = 50-100 nM). SB 203580 has also been shown to be an effective inhibitor of inflammatory cytokine production in vivo in both mice and rats.
Form	Liquid
Formulation	A 1 mg/ml solution of SB 203580 (Cat. No. 559389) in anhydrous DMSO.
Intert gas (Yes/No)	Packaged under inert gas
Chemical formula	C₂₁H₁₆FN₃OS
Structure formula
Purity	≥98% by HPLC
Storage	Protect from light -20°C
Do Not Freeze	Ok to freeze
Special Instructions	Following initial thaw, aliquot, purge with inert gas, and freeze (-20°C).
Toxicity	Irritant
References	Powell, D.J., et al. 2003. Mol. Cell Biol. 23, 7794. Davies, S.P., et al. 2000. Biochem. J. 351, 95. Iwasaki, S., et al. 1999. J. Biol. Chem. 274, 26503. Gallagher, T.F., et al. 1997. Bioorg. Med. Chem. 5, 49. LoGrasso, P.V., et al. 1997. Biochem. 36, 10422. Hazzalin, C.A., et al. 1996. Curr. Biol. 6, 1028. Kramer, R.M., et al. 1996. J. Biol. Chem. 271, 27723. Saklatvala, J., et al. 1996. J. Biol. Chem. 271, 6586. Cuenda, A., et al. 1995. FEBS Lett. 364, 229. Gallagher, T.F., et al. 1995. Bioorg. Med. Chem. Lett. 5, 1171. Lee, J.C., et al. 1994. Nature 372, 739.
Citation	Alexandra Thiel, et al. (2006) Expression of Cyclooxygenase-2 Is Regulated by Glycogen Synthase Kinase-3beta in Gastric Cancer Cells. Journal of Biological Chemistry 281, 4564-4569. Bysani Chandrasekar, et al. (2005) The pro-atherogenic cytokine interleukin-18 induces CXCL16 expression in rat aortic smooth muscle cells via MyD88, interleukin-1 receptor-associated kinase, tumor necrosis factor receptor-associated factor 6, c-Src, phosphatidylinositol 3-kinase, Akt, c-J. Journal of Biological Chemistry 280, 26263-26277. Guadalupe Sabio, et al. (2005) p38γ regulates the localisation of SAP97 in the cytoskeleton by modulating its interaction with GKAP. The EMBO Journal 24, 1134-1145. Jose G. Trevino, et al. (2005) Expression and activity of Src regulate interleukin-8 expression in pancreatic adenocarcinoma cells: implications for angiogenesis. Cancer Research 65, 7214-7222. Wojciech Wojciechowski, et al. (2005) Enhanced Expression of CD20 in Human Tumor B Cells is Controlled Through ERK-Dependent Mechanisms. Journal of Immunology 174, 7859-7868. Yung-Luen Yu, et al. (2005) MAP kinase-mediated phosphorylation of GATA-1 promotes Bcl-XL expression and cell survival. Journal of Biological Chemistry 280, 29533-29542. Naoto Inukai, et al. (2004) A novel hydrogen peroxide-induced phosphorylation and ubiquitination pathway leading to RNA polymerase II proteolysis. Journal of Biological Chemistry 279, 8190-8195.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > MAP Kinase Inhibitors

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