数量	产品目录编号	订购说明	数量 / 包装	公开价
			96-Well Plate

数量	产品目录编号	订购说明	数量 / 包装	公开价
	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

559397 Sigma-AldrichInSolution™ SB 202190 - CAS 152121-30-7 - Calbiochem

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet
Citations

同义词: InSolution™ p38 MAP Kinase Inhibitor II

Primary Target: P38β

Recommended Products

概述

Replacement Information

重要规格表

CAS #	Empirical Formula
152121-30-7	C₂₀H₁₄FN₃O

价格及供货情况

产品目录编号	库存情况	包装	数量 / 包装	价格	数量
559397-1MLCN	正在查询供货情况...... — 目前缺货有货停产少量现货供货情况有待确认登录查看库存有货目前缺货有货其余：另行通知其余：另行通知另行通知联系客户服务 Contact Customer Service 联系客户服务联系客户服务	玻璃瓶	1 ml	正在检索价格...... 无法检索价格。最小订购数量为倍数 Maximum Quantity is 以订单确认为准更多信息您节约了 ()。 — Request Pricing 登录查看价格	查看库存情况 —	添加到收藏夹添加到收藏夹添加到我的收藏夹

Description
Catalogue Number	559397
Brand Family	Calbiochem®
Synonyms	InSolution™ p38 MAP Kinase Inhibitor II

References
References	Ajizian, S.J., et al. 1999. J. Infect. Dis. 179, 939. Singh, R.P., et al. 1999. J. Biol. Chem. 274, 19593. Wang, S.W., et al. 1999. Inflamm. Res. 48, 533. Gallagher, T.F., et al. 1997. Bioorg. Med. Chem. 5, 49. Jiang, Y., et al. 1996. J. Biol. Chem. 271, 17920. Kramer, R.M., et al. 1996. J. Biol. Chem. 271, 27723. Li, Z., et al. 1996. Biochem. Biophys. Res. Commun. 228, 334. Lee, L.C., et al. 1994. Nature 372, 739.

References

Ajizian, S.J., et al. 1999. J. Infect. Dis. 179, 939.
Singh, R.P., et al. 1999. J. Biol. Chem. 274, 19593.
Wang, S.W., et al. 1999. Inflamm. Res. 48, 533.
Gallagher, T.F., et al. 1997. Bioorg. Med. Chem. 5, 49.
Jiang, Y., et al. 1996. J. Biol. Chem. 271, 17920.
Kramer, R.M., et al. 1996. J. Biol. Chem. 271, 27723.
Li, Z., et al. 1996. Biochem. Biophys. Res. Commun. 228, 334.
Lee, L.C., et al. 1994. Nature 372, 739.

Product Information
CAS number	152121-30-7
ATP Competitive	Y
Form	Liquid
Formulation	A 1 mg/ml solution of SB 202190 (Cat. No. 559388) in anhydrous DMSO.
Hill Formula	C₂₀H₁₄FN₃O
Chemical formula	C₂₀H₁₄FN₃O
Reversible	Y
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	P38β
Primary Target IC<sub>50</sub>	16 nM
Primary Target K<sub>i</sub>	16 nM; 350 nM against the kinase activity of p38β; 280 nM against p38 phosphorylation of activating transcription factor 2 (ATF-2)
Purity	≥98% by HPLC
Concentration Label	Please refer to vial label for lot-specific concentration

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information
R Phrase	R: 36/37/38 Irritating to eyes, respiratory system and skin.
S Phrase	S: 26-36 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing.

Product Usage Statements

Storage and Shipping Information
Ship Code	Blue Ice Only
Toxicity	Irritant
Storage	-20°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following initial thaw, aliquot and freeze (-20°C).

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
559397-1MLCN	04055977192629

Documentation

InSolution™ SB 202190 - CAS 152121-30-7 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

InSolution™ SB 202190 - CAS 152121-30-7 - Calbiochem 分析证书

标题	批号
559397	输入批号

参考

参考信息概述
Ajizian, S.J., et al. 1999. J. Infect. Dis. 179, 939. Singh, R.P., et al. 1999. J. Biol. Chem. 274, 19593. Wang, S.W., et al. 1999. Inflamm. Res. 48, 533. Gallagher, T.F., et al. 1997. Bioorg. Med. Chem. 5, 49. Jiang, Y., et al. 1996. J. Biol. Chem. 271, 17920. Kramer, R.M., et al. 1996. J. Biol. Chem. 271, 27723. Li, Z., et al. 1996. Biochem. Biophys. Res. Commun. 228, 334. Lee, L.C., et al. 1994. Nature 372, 739.

参考信息概述

引用

标题

Patrick Michl, et al. (2005) CUTL1 is a target of TGFβ signaling that enhances cancer cell motility and invasiveness. Cancer Cell 7, 521-532.

Yung-Luen Yu, et al. (2005) MAP kinase-mediated phosphorylation of GATA-1 promotes Bcl-XL expression and cell survival. Journal of Biological Chemistry 280, 29533-29542.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	07-April-2008 RFH
Synonyms	InSolution™ p38 MAP Kinase Inhibitor II
Description	A potent and cell-permeable inhibitor of p38 MAP kinase. Inhibits p38 phosphorylation of myelin basic protein (MBP) with no effect on the activity of the ERK or JNK MAP kinase subgroups. Also inhibits the kinase activity of p38β (IC₅₀ = 350 nM) and p38 phosphorylation of activating transcription factor 2 (ATF-2; IC₅₀ = 280 nM). Blocks LPS-induced TNF-α and interleukin biosynthesis. Reported to block LDL expression in Hep52 cells.
Form	Liquid
Formulation	A 1 mg/ml solution of SB 202190 (Cat. No. 559388) in anhydrous DMSO.
Intert gas (Yes/No)	Packaged under inert gas
Concentration Label	Please refer to vial label for lot-specific concentration
CAS number	152121-30-7
Chemical formula	C₂₀H₁₄FN₃O
Structure formula
Purity	≥98% by HPLC
Storage	Protect from light -20°C
Do Not Freeze	Ok to freeze
Special Instructions	Following initial thaw, aliquot and freeze (-20°C).
Toxicity	Irritant
References	Ajizian, S.J., et al. 1999. J. Infect. Dis. 179, 939. Singh, R.P., et al. 1999. J. Biol. Chem. 274, 19593. Wang, S.W., et al. 1999. Inflamm. Res. 48, 533. Gallagher, T.F., et al. 1997. Bioorg. Med. Chem. 5, 49. Jiang, Y., et al. 1996. J. Biol. Chem. 271, 17920. Kramer, R.M., et al. 1996. J. Biol. Chem. 271, 27723. Li, Z., et al. 1996. Biochem. Biophys. Res. Commun. 228, 334. Lee, L.C., et al. 1994. Nature 372, 739.
Citation	Patrick Michl, et al. (2005) CUTL1 is a target of TGFβ signaling that enhances cancer cell motility and invasiveness. Cancer Cell 7, 521-532. Yung-Luen Yu, et al. (2005) MAP kinase-mediated phosphorylation of GATA-1 promotes Bcl-XL expression and cell survival. Journal of Biological Chemistry 280, 29533-29542.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > MAP Kinase Inhibitors

此产品已添加到您的购物车。