数量	产品目录编号	订购说明	数量 / 包装	公开价
			96-Well Plate

数量	产品目录编号	订购说明	数量 / 包装	公开价
	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

555552 Sigma-AldrichInSolution™ Rho Kinase Inhibitor - Calbiochem

The InSolution™ Rho Kinase Inhibitor controls the biological activity of Rho Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

Primary Target: ROCK

Recommended Products

概述

Replacement Information

重要规格表

Empirical Formula
C₁₆H₂₁N₃O₂S • 2HCl

价格及供货情况

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Description
Catalogue Number	555552
Brand Family	Calbiochem®

References
References	Ikenoya, M., et al. 2002. J. Neurochem. 81, 9. Sasaki, Y., et al. 2002. Pharmacol. Ther. 93, 225.

Product Information
ATP Competitive	Y
Form	Liquid
Formulation	A 10 mM (500 µg/128 µl) solution of Rho Kinase Inhibitor (Cat. No. 555550) in H₂O.
Hill Formula	C₁₆H₂₁N₃O₂S • 2HCl
Chemical formula	C₁₆H₂₁N₃O₂S • 2HCl
Reversible	N
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	ROCK
Primary Target K<sub>i</sub>	1.6 nM against Rho-associated kinase (ROCK)
Purity	≥95% by HPLC
Concentration Label	Please refer to vial label for lot-specific concentration

Physicochemical Information
Cell permeable	N

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Blue Ice Only
Toxicity	Harmful
Storage	-20°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following initial thaw, aliquot and freeze (-20°C).

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
555552-500UGCN	04055977268423

Documentation

InSolution™ Rho Kinase Inhibitor - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

InSolution™ Rho Kinase Inhibitor - Calbiochem 分析证书

标题	批号
555552	输入批号

参考

参考信息概述
Ikenoya, M., et al. 2002. J. Neurochem. 81, 9. Sasaki, Y., et al. 2002. Pharmacol. Ther. 93, 225.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	09-September-2008 RFH
Description	A cell-permeable isoquinolinesulfonamide compound that acts as a highly specific, potent, and ATP-competitive inhibitor of G-protein Rho-associated kinase (ROCK; K_i = 1.6 nM). Inhibits other serine/threonine kinases only at higher concentrations (K_i = 630 nM for PKA, 9.27 µM for PKC, and 10.1 µM for MLCK). Shown to selectively block lysophosphatidic acid-induced, but not PDBu-induced, phosphorylation of myristoylated alanine-rich C kinase substrate (MARCKS) in NT-2 cells (IC₅₀ = 2.5 µM). Reported to be a more potent and selective inhibitor than Y-27632 (Cat. No. 688000 & 688001).
Form	Liquid
Formulation	A 10 mM (500 µg/128 µl) solution of Rho Kinase Inhibitor (Cat. No. 555550) in H₂O.
Intert gas (Yes/No)	Packaged under inert gas
Concentration Label	Please refer to vial label for lot-specific concentration
Chemical formula	C₁₆H₂₁N₃O₂S • 2HCl
Structure formula
Purity	≥95% by HPLC
Storage	Protect from light -20°C
Do Not Freeze	Ok to freeze
Special Instructions	Following initial thaw, aliquot and freeze (-20°C).
Toxicity	Harmful
References	Ikenoya, M., et al. 2002. J. Neurochem. 81, 9. Sasaki, Y., et al. 2002. Pharmacol. Ther. 93, 225.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Rho Kinase (ROCK) Inhibitors

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