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A cell-permeable polyketide that displays potent antitumor properties in eukaryotes. Originally identified as a metabolite from the myxobacterium Sorangium cellulosum for its antibiotic activities against yeasts and filamentous fungi, ratjadones inhibit nuclear export of LR-NES (leucine rich-nuclear export signal)-containing proteins by covalently binding to CRM1. Inhibits proliferation (IC50 ≤ 1 ng/ml) and induces cell cycle arrest at G1 phase.
Catalogue Number
553590
Brand Family
Calbiochem®
Synonyms
Ratjadon, Chromosome Region Maintenance 1 Protein Inhibitor II, CRM1 Inhibitor II, Exportin 1 Inhibitor II, XPO1 Inhibitor II
References
References
Köster, M., et al. 2003. Exp. Cell Res.286, 321. Kalesse, M., et al. 2001. Chem biochem2, 709. Gerth, K., et al. 1995. J. Antibiot.48, 973.
≤ 1 ng/ml for inhibiting proliferation and inducing cell cycle arrest at G1 phase
Purity
≥95% by HPLC
Physicochemical Information
Cell permeable
Y
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code
Dry Ice Only
Toxicity
Flammable
Hazardous Materials Attention:
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage
≤ -70°C
Protect from Light
Protect from light
Do not freeze
Ok to freeze
Special Instructions
Following initial thaw, aliquot and freeze (-70°C).
Packaging Information
Packaged under inert gas
Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
产品目录编号
GTIN
553590-2UGCN
04055977193763
Documentation
InSolution™ Ratjadone A, Synthetic - CAS 163564-92-9 - Calbiochem MSDS
InSolution™ Ratjadone A, Synthetic - CAS 163564-92-9 - Calbiochem 分析证书
标题
批号
553590
参考
参考信息概述
Köster, M., et al. 2003. Exp. Cell Res.286, 321. Kalesse, M., et al. 2001. Chem biochem2, 709. Gerth, K., et al. 1995. J. Antibiot.48, 973.
数据表
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
Revision
09-September-2008 RFH
Synonyms
Ratjadon, Chromosome Region Maintenance 1 Protein Inhibitor II, CRM1 Inhibitor II, Exportin 1 Inhibitor II, XPO1 Inhibitor II
Description
A cell-permeable polyketide that displays potent anti-tumor properties in eukaryotes. Originally identified as a metabolite from the myxobacterium Sorangium cellulosum for its antibiotic activities against yeast and filamentous fungi. Ratjadones act by inhibiting nuclear export of LR-NES (leucine rich-nuclear export signal)-containing proteins by covalently binding to CRM1. Inhibits proliferation (IC50 ≤1 ng/ml) and induces cell cycle arrest at the G1 phase.
Form
Liquid
Formulation
A 5 µg/ml solution (2 µg in 400 µl) in methanol.
Intert gas (Yes/No)
Packaged under inert gas
CAS number
163564-92-9
Chemical formula
C₂₈H₄₀O₅
Structure formula
Purity
≥95% by HPLC
Solubility
Methanol (20 mg/ml) or aqueous buffers (≤100 µM)
Storage
Protect from light
≤ -70°C
Do Not Freeze
Ok to freeze
Special Instructions
Following initial thaw, aliquot and freeze (-70°C).
Toxicity
Flammable
References
Köster, M., et al. 2003. Exp. Cell Res.286, 321. Kalesse, M., et al. 2001. Chem biochem2, 709. Gerth, K., et al. 1995. J. Antibiot.48, 973.
