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			96-Well Plate

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	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

553508 Sigma-AldrichInSolution™ Rac1 Inhibitor - Calbiochem

The InSolution™ Rac1Inhibitor, also referenced under CAS 1177865-17-6, controls the biological activity of Rac1. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

InSolution™ Rac1 Inhibitor - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

Primary Target: Rac1

Recommended Products

概述

Replacement Information

重要规格表

Empirical Formula
C₂₄H₃₅N₇ • 3HCl

价格及供货情况

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Description
Catalogue Number	553508
Brand Family	Calbiochem®

References
References	Desire, L., et al. 2005. J. Biol. Chem. 280, 37516. Gao, Y., et al. 2004. Proc. Natl. Acad. Sci. USA 101, 7618. Cancelas, J.A., et. at. 2005. Natr. Med. 11, 886.

Product Information
ATP Competitive	N
Form	Liquid
Formulation	A 50 mM (5 mg/185 µl) solution of Rac1 Inhibitor (Cat. No. 553502) in H₂O.
Hill Formula	C₂₄H₃₅N₇ • 3HCl
Chemical formula	C₂₄H₃₅N₇ • 3HCl
Reversible	Y
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	Rac1
Primary Target IC<sub>50</sub>	~50 µM interfering with the interaction between Rac1 and Rac-specific GEFs (guanine nucleotide exchange factors) Trio and Tiam1
Purity	≥93% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Shipped with Blue Ice or with Dry Ice
Toxicity	Standard Handling
Storage	-20°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following initial thaw, aliquot and freeze (-20°C).

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
553508-5MGCN	04055977193671

Documentation

InSolution™ Rac1 Inhibitor - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

InSolution™ Rac1 Inhibitor - Calbiochem 分析证书

标题	批号
553508	输入批号

参考

参考信息概述
Desire, L., et al. 2005. J. Biol. Chem. 280, 37516. Gao, Y., et al. 2004. Proc. Natl. Acad. Sci. USA 101, 7618. Cancelas, J.A., et. at. 2005. Natr. Med. 11, 886.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	20-December-2010 JSW
Description	A cell-permeable pyrimidine compound that specifically inhibits Rac1 GDP/GTP exchange activity by interfering with the interaction between Rac1 and Rac-specific GEFs (guanine nucleotide exchange factors) Trio and Tiam1 (IC₅₀ ~ 50 µM). Shown to effectively inhibit Rac1-mediated cellular functions in NIH3T3 and PC-3 cells (effective dose ~50 to 100 µM). Also shown to effectively inhibit Rac1 and Rac2 activation in Lin^- c-kit⁺ bone marrow cells stimulated with SDF-1α (effective intraperitoneal dose of 1mg/kg). Exhibits no effect on Cdc42 or RhoA activation and does not affect Rac1 interaction with BcrGAP or PAK1.
Form	Liquid
Formulation	A 50 mM (5 mg/185 µl) solution of Rac1 Inhibitor (Cat. No. 553502) in H₂O.
Intert gas (Yes/No)	Packaged under inert gas
Chemical formula	C₂₄H₃₅N₇ • 3HCl
Structure formula
Purity	≥93% by HPLC
Storage	Protect from light -20°C
Do Not Freeze	Ok to freeze
Special Instructions	Following initial thaw, aliquot and freeze (-20°C).
Toxicity	Standard Handling
References	Desire, L., et al. 2005. J. Biol. Chem. 280, 37516. Gao, Y., et al. 2004. Proc. Natl. Acad. Sci. USA 101, 7618. Cancelas, J.A., et. at. 2005. Natr. Med. 11, 886.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Rac Inhibitors

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