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			96-Well Plate

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	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

551476 Sigma-AldrichInSolution™ Q-VD-OPh, Non-O-methylated - Calbiochem

InSolution™ Q-VD-OPh, Non-O-methylated, is a cell-permeable, irreversible, broad-spectrum inhibitor of caspases (IC₅₀ = 50, 100, 430, and <25 nM for caspase-1,-8, -9, and -3, respectively).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
小册子
Data Sheet
Citations

同义词: N-(2-Quinolyl)valyl-aspartyl-(2,6-difluorophenoxy)methyl Ketone

Primary Target: caspase-1

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概述

Replacement Information

重要规格表

Empirical Formula
C₂₆H₂₅F₂N₃O₆

价格及供货情况

产品目录编号	库存情况	包装	数量 / 包装	价格	数量
551476-1MGCN	正在查询供货情况...... — 目前缺货有货停产少量现货供货情况有待确认登录查看库存有货目前缺货有货其余：另行通知其余：另行通知另行通知联系客户服务 Contact Customer Service 联系客户服务联系客户服务	塑胶安瓿;塑胶针药瓶	1 mg	正在检索价格...... 无法检索价格。最小订购数量为倍数 Maximum Quantity is 以订单确认为准更多信息您节约了 ()。 — Request Pricing 登录查看价格	查看库存情况 —	添加到收藏夹添加到收藏夹添加到我的收藏夹
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Description
Overview	A cell-permeable, irreversible, broad-spectrum caspase inhibitor (IC₅₀ = 50, 100, 430, and <25 nM for caspase-1,-8, -9, and -3, respectively) with effective antiapoptotic properties against all major caspase-mediated cellular apoptosis pathways. Exhibits no cytotoxic effects even at extremely high concentrations. Shown to reduce ischemic brain damage and stroke-induced programmed cell death in thymus and spleen.
Catalogue Number	551476
Brand Family	Calbiochem®
Synonyms	N-(2-Quinolyl)valyl-aspartyl-(2,6-difluorophenoxy)methyl Ketone

References
References	Braun, J.S., et al. 2007. Exp. Neurol. 206, 183. Caserta, T.M., et al. 2003. Apoptosis 8, 345. Rebbaa, A., et al. 2003. Oncogene 22, 2805.

Product Information
ATP Competitive	N
Form	Liquid
Formulation	Supplied as a 10 mM (1 mg/195 µl) solution in DMSO.
Hill Formula	C₂₆H₂₅F₂N₃O₆
Chemical formula	C₂₆H₂₅F₂N₃O₆
Hygroscopic	Hygroscopic
Reversible	N
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	caspase-1
Primary Target IC<sub>50</sub>	50, 100, 430, and <25 nM for caspase-1,-8, -9, and -3, respectively
Purity	≥90% by HPLC

Physicochemical Information
Cell permeable	Y
Peptide Sequence	Q-Val-Asp-CH₂-OPh

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Shipped with Blue Ice or with Dry Ice
Toxicity	Irritant
Storage	-20°C
Protect from Light	Protect from light
Hygroscopic	Hygroscopic
Do not freeze	Ok to freeze
Special Instructions	Following initial thaw, aliquot and freeze (-20°C).

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
551476-1MGCN	04055977268898
551476-5MGCN	04055977268904

Documentation

InSolution™ Q-VD-OPh, Non-O-methylated - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

InSolution™ Q-VD-OPh, Non-O-methylated - Calbiochem 分析证书

标题	批号
551476	输入批号

参考

参考信息概述
Braun, J.S., et al. 2007. Exp. Neurol. 206, 183. Caserta, T.M., et al. 2003. Apoptosis 8, 345. Rebbaa, A., et al. 2003. Oncogene 22, 2805.

小册子

标题
Caspases and other Apoptosis Related Tools Brochure

引用

标题

Braun, J.S., et al. 2007. Exp. Neurol. 206, 183.

Jessica H. Dworet and Judy L. Meinkoth. 2006.Molecular Endocrinology 20, 1112.

Ademi E. Santiago-Walker, et al. (2005) Protein Kinase C δ Stimulates Apoptosis by Initiating G1 Phase Cell Cycle Progression and S Phase Arrest. Journal of Biological Chemistry 280, 32107-32114.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	28-February-2012 RFH
Synonyms	N-(2-Quinolyl)valyl-aspartyl-(2,6-difluorophenoxy)methyl Ketone
Description	A cell-permeable, irreversible, broad-spectrum caspase inhibitor (IC₅₀ = 50 nM for caspase-1; IC₅₀ = 100 nM for caspase-8; IC₅₀ = 430 nM for caspase-9; IC₅₀ < 25 nM for caspase-3). Exhibits effective anti-apoptotic properties against all major caspase-mediated cellular apoptosis pathways, including caspase 9/3, caspase 8/10, and caspase 12. Does not exhibit toxic effects even at high concentrations. To reduce hydrophobicity of the peptide and facilitate its use in aqueous media the aspartyl residue is not O-methylated. Shown to reduce ischemic brain damage and stroke-induced programmed cell death in thymus and spleen.
Form	Liquid
Formulation	Supplied as a 10 mM (1 mg/195 µl) solution in DMSO.
Intert gas (Yes/No)	Packaged under inert gas
Chemical formula	C₂₆H₂₅F₂N₃O₆
Peptide Sequence	Q-Val-Asp-CH₂-OPh
Structure formula
Purity	≥90% by HPLC
Storage	Protect from light -20°C Hygroscopic
Do Not Freeze	Ok to freeze
Special Instructions	Following initial thaw, aliquot and freeze (-20°C).
Toxicity	Irritant
References	Braun, J.S., et al. 2007. Exp. Neurol. 206, 183. Caserta, T.M., et al. 2003. Apoptosis 8, 345. Rebbaa, A., et al. 2003. Oncogene 22, 2805.
Citation	Braun, J.S., et al. 2007. Exp. Neurol. 206, 183. Jessica H. Dworet and Judy L. Meinkoth. 2006.Molecular Endocrinology 20, 1112. Ademi E. Santiago-Walker, et al. (2005) Protein Kinase C δ Stimulates Apoptosis by Initiating G1 Phase Cell Cycle Progression and S Phase Arrest. Journal of Biological Chemistry 280, 32107-32114.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Apoptosis/Necrosis Inhibitors > Caspase Inhibitors

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