数量	产品目录编号	订购说明	数量 / 包装	公开价
			96-Well Plate

数量	产品目录编号	订购说明	数量 / 包装	公开价
	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

500582 Sigma-AldrichInSolution™ Phorbol-12-myristate-13-acetate - CAS 16561-29-8 - Calbiochem

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
参考
Data Sheet

同义词: 12-O-Tetradecanoyl-phorbol-13-acetate, PMA, TPA

Primary Target: PKC

Recommended Products

概述

Replacement Information

重要规格表

CAS #	Empirical Formula
16561-29-8	C₃₆H₅₆O₈

价格及供货情况

产品目录编号	库存情况	包装	数量 / 包装	价格	数量
5.00582.0001	正在查询供货情况...... — 目前缺货有货停产少量现货供货情况有待确认登录查看库存有货目前缺货有货其余：另行通知其余：另行通知另行通知联系客户服务 Contact Customer Service 联系客户服务联系客户服务	玻璃瓶	2 mg	正在检索价格...... 无法检索价格。最小订购数量为倍数 Maximum Quantity is 以订单确认为准更多信息您节约了 ()。 — Request Pricing 登录查看价格	查看库存情况 —	添加到收藏夹添加到收藏夹添加到我的收藏夹

Description
Overview	Most commonly-used phorbol ester. Extremely potent mouse skin tumor promoter. Activates protein kinase C in vivo and in vitro, even at nM concentrations. Promotes the expression of iNOS in cultured hepatocytes. Activates Ca²⁺-ATPase and potentiates forskolin (Cat. No. 344270, Cat. No. 344282)-induced cAMP formation. Inhibits apoptosis induced by the Fas antigen, but induces apoptosis in HL-60 promyelocytic leukemia cells. Its binding is reversible.
Catalogue Number	500582
Brand Family	Calbiochem®
Synonyms	12-O-Tetradecanoyl-phorbol-13-acetate, PMA, TPA

References
References	Powell, D.J., et al. 2003. Mol. Cell Biol. 23, 7794. Tepper, C.G., et al. 1995. Proc. Natl. Acad. Sci. USA 92, 8443. Oishi, K., and Yamaguchi, M. 1994. J. Cell. Biochem. 55, 168. Macfarlane, D.E., and O'Donnell, P.S. 1993. Leukemia 7, 1846. Ghandi, V.C. and Jones, D.J., 1992. Neuropharmacol. 31, 1101. Hortelano, S., et al. 1992. J. Biol. Chem. 267, 24937. Kontny, E., et al. 1992. Eur. J. Pharmacol. 227, 333. Zanaboni, P.B., et al. 1992. J. Appl. Physiol. 73, 2011. Saltis, J., et al. 1991. J. Biol. Chem. 266, 261. Beguinot, L., et al. 1985. Proc. Natl. Acad. Sci. USA 82, 2774. Perchellet, J. 1985. Carcinogenesis 6, 567. Nishizuka, Y. 1984. Science 255, 1365. Mastro, A. 1982. Lymphokines 6, 263.

References

Powell, D.J., et al. 2003. Mol. Cell Biol. 23, 7794.
Tepper, C.G., et al. 1995. Proc. Natl. Acad. Sci. USA 92, 8443.
Oishi, K., and Yamaguchi, M. 1994. J. Cell. Biochem. 55, 168.
Macfarlane, D.E., and O'Donnell, P.S. 1993. Leukemia 7, 1846.
Ghandi, V.C. and Jones, D.J., 1992. Neuropharmacol. 31, 1101.
Hortelano, S., et al. 1992. J. Biol. Chem. 267, 24937.
Kontny, E., et al. 1992. Eur. J. Pharmacol. 227, 333.
Zanaboni, P.B., et al. 1992. J. Appl. Physiol. 73, 2011.
Saltis, J., et al. 1991. J. Biol. Chem. 266, 261.
Beguinot, L., et al. 1985. Proc. Natl. Acad. Sci. USA 82, 2774.
Perchellet, J. 1985. Carcinogenesis 6, 567.
Nishizuka, Y. 1984. Science 255, 1365.
Mastro, A. 1982. Lymphokines 6, 263.

Product Information
CAS number	16561-29-8
Form	Liquid
Formulation	A 10 mM (2 mg/324 µL) solution of Phorbol-12-myristate-13-acetate (Cat. No. 524400) in DMSO.
Hill Formula	C₃₆H₅₆O₈
Chemical formula	C₃₆H₅₆O₈
Hygroscopic	Hygroscopic
Reversible	Y
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	PKC
Secondary target	Ca²⁺-ATPase
Purity	≥98% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information
R Phrase	R: 36/38 Irritating to eyes and skin.
S Phrase	S: 26-36 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing.

Product Usage Statements

Storage and Shipping Information
Ship Code	Dry Ice Only
Toxicity	Irritant
Storage	≤ -70°C
Protect from Light	Protect from light
Hygroscopic	Hygroscopic
Avoid freeze/thaw	Avoid freeze/thaw
Do not freeze	Ok to freeze
Special Instructions	Following initial thaw, aliquot and freeze (-70°C). Use only fresh DMSO for preparing further dilutions.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
5.00582.0001	04055977244977

Documentation

InSolution™ Phorbol-12-myristate-13-acetate - CAS 16561-29-8 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

参考

参考信息概述
Powell, D.J., et al. 2003. Mol. Cell Biol. 23, 7794. Tepper, C.G., et al. 1995. Proc. Natl. Acad. Sci. USA 92, 8443. Oishi, K., and Yamaguchi, M. 1994. J. Cell. Biochem. 55, 168. Macfarlane, D.E., and O'Donnell, P.S. 1993. Leukemia 7, 1846. Ghandi, V.C. and Jones, D.J., 1992. Neuropharmacol. 31, 1101. Hortelano, S., et al. 1992. J. Biol. Chem. 267, 24937. Kontny, E., et al. 1992. Eur. J. Pharmacol. 227, 333. Zanaboni, P.B., et al. 1992. J. Appl. Physiol. 73, 2011. Saltis, J., et al. 1991. J. Biol. Chem. 266, 261. Beguinot, L., et al. 1985. Proc. Natl. Acad. Sci. USA 82, 2774. Perchellet, J. 1985. Carcinogenesis 6, 567. Nishizuka, Y. 1984. Science 255, 1365. Mastro, A. 1982. Lymphokines 6, 263.

参考信息概述

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	28-March-2013 JSW
Synonyms	12-O-Tetradecanoyl-phorbol-13-acetate, PMA, TPA
Description	Most commonly-used phorbol ester. Extremely potent mouse skin tumor promoter. Activates protein kinase C in vivo and in vitro, even at nM concentrations. Promotes the expression of iNOS in cultured hepatocytes. Activates Ca²⁺-ATPase and potentiates forskolin (Cat. No. 344270, Cat. No. 344282)-induced cAMP formation. Inhibits apoptosis induced by the Fas antigen, but induces apoptosis in HL-60 promyelocytic leukemia cells. Its binding is reversible.
Form	Liquid
Formulation	A 10 mM (2 mg/324 µL) solution of Phorbol-12-myristate-13-acetate (Cat. No. 524400) in DMSO.
Intert gas (Yes/No)	Packaged under inert gas
CAS number	16561-29-8
Chemical formula	C₃₆H₅₆O₈
Structure formula
Purity	≥98% by HPLC
Storage	Protect from light Avoid freeze/thaw ≤ -70°C Hygroscopic
Do Not Freeze	Ok to freeze
Special Instructions	Following initial thaw, aliquot and freeze (-70°C). Use only fresh DMSO for preparing further dilutions.
Toxicity	Irritant
References	Powell, D.J., et al. 2003. Mol. Cell Biol. 23, 7794. Tepper, C.G., et al. 1995. Proc. Natl. Acad. Sci. USA 92, 8443. Oishi, K., and Yamaguchi, M. 1994. J. Cell. Biochem. 55, 168. Macfarlane, D.E., and O'Donnell, P.S. 1993. Leukemia 7, 1846. Ghandi, V.C. and Jones, D.J., 1992. Neuropharmacol. 31, 1101. Hortelano, S., et al. 1992. J. Biol. Chem. 267, 24937. Kontny, E., et al. 1992. Eur. J. Pharmacol. 227, 333. Zanaboni, P.B., et al. 1992. J. Appl. Physiol. 73, 2011. Saltis, J., et al. 1991. J. Biol. Chem. 266, 261. Beguinot, L., et al. 1985. Proc. Natl. Acad. Sci. USA 82, 2774. Perchellet, J. 1985. Carcinogenesis 6, 567. Nishizuka, Y. 1984. Science 255, 1365. Mastro, A. 1982. Lymphokines 6, 263.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Activators > Kinases Activators > Protein Kinase C Activators

此产品已添加到您的购物车。