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496000 Sigma-AldrichInSolution™ OM99-2 - CAS 314266-76-7 - Calbiochem

An eight residue peptidomimetic, tight binding transition-state analog inhibitor of human brain memapsin 2.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

分析证书
参考
Data Sheet

同义词: EVNLΨAAEF

Primary Target: human brain memapsin 2

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概述

Replacement Information

重要规格表

CAS #	Empirical Formula
314266-76-7	C₄₁H₆₄N₈O₁₄

价格及供货情况

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Description
Overview	An eight residue peptidomimetic, tight binding transition-state analog inhibitor of human brain memapsin 2 (K_i = 1.6 nM, recombinant memapsin 2; K_i = 9.58 nM, recombinant pro-memapsin 2). Also inhibits cathepsin D (K_i = 48 nM). This aspartyl protease inhibitor is designed from the template of the β-secretase site of Swedish β-amyloid precursor protein (APP) with Asp to Ala replacement; also includes a nonhydrolyzable hydroxyethylene isostere between Leu and Ala.
Catalogue Number	496000
Brand Family	Calbiochem®
Synonyms	EVNLΨAAEF

References
References	Ghosh, A.K., et al. 2001. J. Med. Chem. 44, 2865. Turner III, R.T., et al. 2001. Biochemistry 40, 10001. Ghosh, A.K., et al. 2000. J. Am. Chem. Soc. 122, 3522. Hong, L., et al. 2000. Science 290,150.

Product Information
CAS number	314266-76-7
ATP Competitive	N
Form	Liquid
Formulation	A 1 mM (250µg in 280 µl) solution in DMSO. Supplied as a trifluoroacetate salt.
Hill Formula	C₄₁H₆₄N₈O₁₄
Chemical formula	C₄₁H₆₄N₈O₁₄
Reversible	N
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	human brain memapsin 2
Primary Target K<sub>i</sub>	1.6 nM against recombinant memapsin 2; 9.58 nM against recombinant pro-memapsin 2; 48 nM against cathepsin D
Purity	≥90% by HPLC

Physicochemical Information
Cell permeable	N
Peptide Sequence	Glu-Val-Asn-Leu-Ψ-Ala-Ala-Glu-Phe [Ψ denotes replacement of CONH by (S)-CH(OH)CH₂]

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	-20°C
Protect from Light	Protect from light
Protect from Moisture	Protect from moisture
Do not freeze	Ok to freeze
Special Instructions	Following initial thaw, aliquot and freeze (-20°C). Avoid freeze/thaw cycles of solutions.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
496000-250UGCN	04055977199826

Documentation

InSolution™ OM99-2 - CAS 314266-76-7 - Calbiochem 分析证书

标题	批号
496000	输入批号

参考

参考信息概述
Ghosh, A.K., et al. 2001. J. Med. Chem. 44, 2865. Turner III, R.T., et al. 2001. Biochemistry 40, 10001. Ghosh, A.K., et al. 2000. J. Am. Chem. Soc. 122, 3522. Hong, L., et al. 2000. Science 290,150.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	13-August-2008 RFH
Synonyms	EVNLΨAAEF
Description	A peptidomimetic, highly potent, tight-binding transition-state analog inhibitor of human brain β-secretase (K_i = 1.6 nM, recombinant memapsin-2; K_i = 9.58 nM, recombinant pro-memapsin 2). Designed from the template of the β-secretase site of Swedish β-amyloid precursor protein (APP) with Asp to Ala replacement. Includes a nonhydrolyzable hydroxyethylene isostere between Leu and Ala. Also reported to inhibit cathepsin D at higher levels (K_i = 48 nM).
Form	Liquid
Formulation	A 1 mM (250µg in 280 µl) solution in DMSO. Supplied as a trifluoroacetate salt.
Intert gas (Yes/No)	Packaged under inert gas
CAS number	314266-76-7
Chemical formula	C₄₁H₆₄N₈O₁₄
Peptide Sequence	Glu-Val-Asn-Leu-Ψ-Ala-Ala-Glu-Phe [Ψ denotes replacement of CONH by (S)-CH(OH)CH₂]
Structure formula
Purity	≥90% by HPLC
Storage	Protect from moisture Protect from light -20°C
Do Not Freeze	Ok to freeze
Special Instructions	Following initial thaw, aliquot and freeze (-20°C). Avoid freeze/thaw cycles of solutions.
Toxicity	Standard Handling
References	Ghosh, A.K., et al. 2001. J. Med. Chem. 44, 2865. Turner III, R.T., et al. 2001. Biochemistry 40, 10001. Ghosh, A.K., et al. 2000. J. Am. Chem. Soc. 122, 3522. Hong, L., et al. 2000. Science 290,150.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Neurobiology / Neurodegeneration > Secretase Inhibitors

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