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444151 Sigma-AldrichInSolution™ Nutlin-3, Racemic - Calbiochem

InSolution™ Nutlin-3, Racemic - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: MDM2 Inhibitor IV

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概述

Replacement Information

重要规格表

Empirical Formula
C₃₀H₃₀Cl₂N₄O₄

价格及供货情况

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Description
Catalogue Number	444151
Brand Family	Calbiochem®
Synonyms	MDM2 Inhibitor IV

References
References	Thompson, T., et al. 2004. J. Biol. Chem. 279, 53015. Vassilev, L.T., et al. 2004. Science 303, 844.

Product Information
Form	Liquid
Formulation	A 10 mM (1 mg/172 µl) solution of MDM2 Antagonist, Nutlin-3, Racemic (Cat. No. 444143) in DMSO
Hill Formula	C₃₀H₃₀Cl₂N₄O₄
Chemical formula	C₃₀H₃₀Cl₂N₄O₄
Hygroscopic	Hygroscopic
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Purity	≥98% by HPLC

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information
R Phrase	R: 36/38 Irritating to eyes and skin.
S Phrase	S: 26-36-45 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).

Product Usage Statements

Storage and Shipping Information
Ship Code	Shipped with Blue Ice or with Dry Ice
Toxicity	Irritant
Storage	-20°C
Protect from Light	Protect from light
Hygroscopic	Hygroscopic
Do not freeze	Ok to freeze
Special Instructions	Following initial thaw, aliquot and freeze (-20°C).

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
444151-1MGCN	04055977205466

Documentation

InSolution™ Nutlin-3, Racemic - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

InSolution™ Nutlin-3, Racemic - Calbiochem 分析证书

标题	批号
444151	输入批号

参考

参考信息概述
Thompson, T., et al. 2004. J. Biol. Chem. 279, 53015. Vassilev, L.T., et al. 2004. Science 303, 844.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	28-August-2008 JSW
Synonyms	MDM2 Inhibitor IV
Description	A cell-permeable, potent, and selective MDM2 antagonist (IC₅₀ = 90 nM for Nutlin-3a and 13.6 µM for Nutlin-3b) that displays antitumor properties. Activates the p53 pathway by binding MDM2 in the p53-binding pocket and inhibiting the MDM2-p53 interaction. Shown to induce apoptosis in several cancer cell lines with wild-type p53 and in xenografted tumor mice.
Form	Liquid
Formulation	A 10 mM (1 mg/172 µl) solution of MDM2 Antagonist, Nutlin-3, Racemic (Cat. No. 444143) in DMSO
Intert gas (Yes/No)	Packaged under inert gas
Chemical formula	C₃₀H₃₀Cl₂N₄O₄
Structure formula
Purity	≥98% by HPLC
Storage	Protect from light -20°C Hygroscopic
Do Not Freeze	Ok to freeze
Special Instructions	Following initial thaw, aliquot and freeze (-20°C).
Toxicity	Irritant
References	Thompson, T., et al. 2004. J. Biol. Chem. 279, 53015. Vassilev, L.T., et al. 2004. Science 303, 844.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > DNA Damage/Repair > MDM2 Inhibitors

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