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			96-Well Plate

数量	产品目录编号	订购说明	数量 / 包装	公开价
	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

505224 Sigma-AldrichInSolution™ Necrostatin-1 - Calbiochem

InSolution™ Necrostatin-1 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
参考
Data Sheet

同义词: Necrosis Inhibitor II, 5-((1H-Indol-3-yl)methyl)-3-methyl-2-thioxoimidazolidin-4-one; 5-(Indol-3-ylmethyl)-(2-thio-3-methyl)hydantoin, MTH-Trp, Methyl-thiohydantoin-tryptophan, Nec-1, Nec1, Necrosome Inhibitor I, RIP1 Inhibitor I, RIPK 1 Inhibitor I, Receptor-Interacting Protein 1 Inhibitor I

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概述

Replacement Information

重要规格表

Empirical Formula
C₁₃H₁₃N₃OS

价格及供货情况

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Description
Overview	A cell-permeable, potent, and selective blocker of necroptosis (EC₅₀ = 494 nM in FADD-deficient Jurkat cells treated with TNF-α), a nonapoptotic necrotic cell death pathway mediated by death-domain receptors (DRs) that offers neuroprotection in a murine model of ischemic brain injury. Exhibits no effect on DR-induced apoptosis. Also acts as a selective and ATP-competitive inhibitor of RIP1 kinase with negligible effect on RIP2 kinase activity. Nec-1 target appears to be a critical common necroptotic step upstream of execution events and downstream of DRs. Inactive control, Nec-1i, is also available (Cat. No. 480066).
Catalogue Number	505224
Brand Family	Calbiochem®
Synonyms	Necrosis Inhibitor II, 5-((1H-Indol-3-yl)methyl)-3-methyl-2-thioxoimidazolidin-4-one; 5-(Indol-3-ylmethyl)-(2-thio-3-methyl)hydantoin, MTH-Trp, Methyl-thiohydantoin-tryptophan, Nec-1, Nec1, Necrosome Inhibitor I, RIP1 Inhibitor I, RIPK 1 Inhibitor I, Receptor-Interacting Protein 1 Inhibitor I

References
References	Degterev, A., et al. 2013. Nat. Chem. Biol. 9, 192. Degterev, A., et al. 2012. Cell Death Differ. 20, 366. Christofferson, D.E., et al. 2012. Cell Death Dis. 3, e320. Takahashi, N., et al. 2012. Cell Death Dis. 3, e437. Degterev, A., et al. 2008. Nat. Chem. Biol. 4, 313. Degterev, A., et al. 2005. Nat. Chem. Biol. 1, 112. Muller, A.J., et al. 2005. Nat. Med. 11, 312. Teng, X., et al. 2005. Bioorg. Med. Chem. Lett. 15, 5039.

References

Degterev, A., et al. 2013. Nat. Chem. Biol. 9, 192.
Degterev, A., et al. 2012. Cell Death Differ. 20, 366.
Christofferson, D.E., et al. 2012. Cell Death Dis. 3, e320.
Takahashi, N., et al. 2012. Cell Death Dis. 3, e437.
Degterev, A., et al. 2008. Nat. Chem. Biol. 4, 313.
Degterev, A., et al. 2005. Nat. Chem. Biol. 1, 112.
Muller, A.J., et al. 2005. Nat. Med. 11, 312.
Teng, X., et al. 2005. Bioorg. Med. Chem. Lett. 15, 5039.

Product Information
Form	Liquid
Formulation	A 25 mM (10 mg/1.54 ml) sterile-filtered solution of Necrostatin-1 (Cat. No. 480065) in DMSO.
Hill Formula	C₁₃H₁₃N₃OS
Chemical formula	C₁₃H₁₃N₃OS
Hygroscopic	Hygroscopic
Reversible	Y
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Purity	≥99% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information
R Phrase	R: 36/38 Irritating to eyes and skin.
S Phrase	S: 26-36-45 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).

Product Usage Statements

Storage and Shipping Information
Ship Code	Dry Ice Only
Toxicity	Irritant
Storage	≤ -70°C
Protect from Light	Protect from light
Hygroscopic	Hygroscopic
Avoid freeze/thaw	Avoid freeze/thaw
Do not freeze	Ok to freeze
Special Instructions	Following initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 1 year at -70°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
5.05224.0001	04055977263473

Documentation

InSolution™ Necrostatin-1 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

参考

参考信息概述
Degterev, A., et al. 2013. Nat. Chem. Biol. 9, 192. Degterev, A., et al. 2012. Cell Death Differ. 20, 366. Christofferson, D.E., et al. 2012. Cell Death Dis. 3, e320. Takahashi, N., et al. 2012. Cell Death Dis. 3, e437. Degterev, A., et al. 2008. Nat. Chem. Biol. 4, 313. Degterev, A., et al. 2005. Nat. Chem. Biol. 1, 112. Muller, A.J., et al. 2005. Nat. Med. 11, 312. Teng, X., et al. 2005. Bioorg. Med. Chem. Lett. 15, 5039.

参考信息概述

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	13-December-2013 JSW
Synonyms	Necrosis Inhibitor II, 5-((1H-Indol-3-yl)methyl)-3-methyl-2-thioxoimidazolidin-4-one; 5-(Indol-3-ylmethyl)-(2-thio-3-methyl)hydantoin, MTH-Trp, Methyl-thiohydantoin-tryptophan, Nec-1, Nec1, Necrosome Inhibitor I, RIP1 Inhibitor I, RIPK 1 Inhibitor I, Receptor-Interacting Protein 1 Inhibitor I
Description	A cell-permeable, potent, and selective blocker of necroptosis (EC₅₀ = 494 nM in FADD-deficient Jurkat cells treated with TNF-α), a nonapoptotic necrotic cell death pathway mediated by death-domain receptors (DRs) that offers neuroprotection in a murine model of ischemic brain injury. Exhibits no effect on DR-induced apoptosis. Also acts as a selective and ATP-competitive inhibitor of RIP1 kinase with negligible effect on RIP2 kinase activity. Nec-1 target appears to be a critical common necroptotic step upstream of execution events and downstream of DRs. Inactive control, Nec-1i, is also available (Cat. No. 480066).
Form	Liquid
Formulation	A 25 mM (10 mg/1.54 ml) sterile-filtered solution of Necrostatin-1 (Cat. No. 480065) in DMSO.
Intert gas (Yes/No)	Packaged under inert gas
Chemical formula	C₁₃H₁₃N₃OS
Structure formula
Purity	≥99% by HPLC
Storage	Protect from light Avoid freeze/thaw ≤ -70°C Hygroscopic
Do Not Freeze	Ok to freeze
Special Instructions	Following initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 1 year at -70°C.
Toxicity	Irritant
References	Degterev, A., et al. 2013. Nat. Chem. Biol. 9, 192. Degterev, A., et al. 2012. Cell Death Differ. 20, 366. Christofferson, D.E., et al. 2012. Cell Death Dis. 3, e320. Takahashi, N., et al. 2012. Cell Death Dis. 3, e437. Degterev, A., et al. 2008. Nat. Chem. Biol. 4, 313. Degterev, A., et al. 2005. Nat. Chem. Biol. 1, 112. Muller, A.J., et al. 2005. Nat. Med. 11, 312. Teng, X., et al. 2005. Bioorg. Med. Chem. Lett. 15, 5039.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Apoptosis/Necrosis Inhibitors > Necrosis Inhibitors

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