数量	产品目录编号	订购说明	数量 / 包装	公开价
			96-Well Plate

数量	产品目录编号	订购说明	数量 / 包装	公开价
	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

474788 Sigma-AldrichInSolution™ MG-132 in EtOH, ≥95% by HPLC - Calbiochem

Potent, reversible, and cell-permeable proteasome inhibitor. Reduces the degradation of ubiquitin-conjugated proteins in mammalian cells and permeable stains of yeast by the 26S complex.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: Proteasome Inhibitor XI

Recommended Products

概述

Replacement Information

重要规格表

Empirical Formula
C₂₆H₄₁N₃O₅

价格及供货情况

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Description
Overview	Potent, reversible, and cell-permeable proteasome inhibitor (K_i = 4 nM). Reduces the degradation of ubiquitin-conjugated proteins in mammalian cells and permeable stains of yeast by the 26S complex without affecting its ATPase or isopeptidase activities. Activates c-Jun N-terminal kinase (JNK1) which initiates apoptosis. Inhibits NF-κB activation (IC₅₀ = 3 µM). This material is ≥95% pure by HPLC. A material with ≥98% purity by HPLC (Cat. No. 474791) and the solid form of this compound (Cat. No. 474787) are also available.
Catalogue Number	474788
Brand Family	Calbiochem®
Synonyms	Proteasome Inhibitor XI
Application Data

References
References	Steinhilb, M.L., et al. 2001. J. Biol. Chem. 276, 4476. Meriin, A.B., et al. 1998. J. Biol. Chem. 273, 6373. Adams, J., and Stein, R. 1996. Ann. Rep. Med. Chem. 31, 279. Klafki, H.W., et al. 1996. J. Biol. Chem. 271, 2865. Lee, D.H., and Goldberg, A.L., 1996. J. Biol. Chem. 271, 27280. Wiertz, E.J., et al. 1996. Cell 84, 769. Jensen, T.J., et al. 1995. Cell 83, 129. Read, M.A., et al. 1995. Immunity 2, 493. Rock, K.L., et al. 1994. Cell 78, 761.

References

Steinhilb, M.L., et al. 2001. J. Biol. Chem. 276, 4476.
Meriin, A.B., et al. 1998. J. Biol. Chem. 273, 6373.
Adams, J., and Stein, R. 1996. Ann. Rep. Med. Chem. 31, 279.
Klafki, H.W., et al. 1996. J. Biol. Chem. 271, 2865.
Lee, D.H., and Goldberg, A.L., 1996. J. Biol. Chem. 271, 27280.
Wiertz, E.J., et al. 1996. Cell 84, 769.
Jensen, T.J., et al. 1995. Cell 83, 129.
Read, M.A., et al. 1995. Immunity 2, 493.
Rock, K.L., et al. 1994. Cell 78, 761.

Product Information
Form	Liquid
Formulation	A 20 mM (10 mg/1.05 ml) solution of MG-132, ≥95% by HPLC (Cat. No. 474787) in EtOH.
Hill Formula	C₂₆H₄₁N₃O₅
Chemical formula	C₂₆H₄₁N₃O₅
Reversible	Y
Quality Level	MQ100

Applications

Biological Information
Primary Target K<sub>i</sub>	K_i = 4 nM for proteasomal inhibition
Secondary target	IKK
Purity	≥95% by HPLC

Physicochemical Information
Cell permeable	Y
Peptide Sequence	Z-Leu-Leu-Leu-CHO

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information
R Phrase	R: 11-22 Highly flammable. Harmful if swallowed.
S Phrase	S: 16-7 Keep away from sources of ignition - No Smoking. Keep container tightly closed.

Product Usage Statements

Storage and Shipping Information
Ship Code	Dry Ice Only
Toxicity	Flammable
Hazardous Materials Attention:	Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage	≤ -70°C
Protect from Light	Protect from light
Avoid freeze/thaw	Avoid freeze/thaw
Do not freeze	Ok to freeze
Special Instructions	Following initital thaw, aliquot and freeze (-70°C).

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
474788-10MGCN	04055977185461

Documentation

InSolution™ MG-132 in EtOH, ≥95% by HPLC - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

InSolution™ MG-132 in EtOH, ≥95% by HPLC - Calbiochem 分析证书

标题	批号
474788	输入批号

参考

参考信息概述
Steinhilb, M.L., et al. 2001. J. Biol. Chem. 276, 4476. Meriin, A.B., et al. 1998. J. Biol. Chem. 273, 6373. Adams, J., and Stein, R. 1996. Ann. Rep. Med. Chem. 31, 279. Klafki, H.W., et al. 1996. J. Biol. Chem. 271, 2865. Lee, D.H., and Goldberg, A.L., 1996. J. Biol. Chem. 271, 27280. Wiertz, E.J., et al. 1996. Cell 84, 769. Jensen, T.J., et al. 1995. Cell 83, 129. Read, M.A., et al. 1995. Immunity 2, 493. Rock, K.L., et al. 1994. Cell 78, 761.

参考信息概述

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	26-March-2012 JSW
Synonyms	Proteasome Inhibitor XI
Application Data
Description	Potent, reversible, and cell-permeable proteasome inhibitor (K_i = 4 nM). Reduces the degradation of ubiquitin-conjugated proteins in mammalian cells and permeable stains of yeast by the 26S complex without affecting its ATPase or isopeptidase activities. Activates c-Jun N-terminal kinase (JNK1) which initiates apoptosis. Inhibits NF-κB activation (IC₅₀ = 3 µM). This material is ≥95% pure by HPLC. A material with ≥98% purity by HPLC (Cat. No. 474791) is also available.
Form	Liquid
Formulation	A 20 mM (10 mg/1.05 ml) solution of MG-132, ≥95% by HPLC (Cat. No. 474787) in EtOH.
Intert gas (Yes/No)	Packaged under inert gas
Chemical formula	C₂₆H₄₁N₃O₅
Peptide Sequence	Z-Leu-Leu-Leu-CHO
Purity	≥95% by HPLC
Storage	Protect from light Avoid freeze/thaw ≤ -70°C
Do Not Freeze	Ok to freeze
Special Instructions	Following initital thaw, aliquot and freeze (-70°C).
Toxicity	Flammable
References	Steinhilb, M.L., et al. 2001. J. Biol. Chem. 276, 4476. Meriin, A.B., et al. 1998. J. Biol. Chem. 273, 6373. Adams, J., and Stein, R. 1996. Ann. Rep. Med. Chem. 31, 279. Klafki, H.W., et al. 1996. J. Biol. Chem. 271, 2865. Lee, D.H., and Goldberg, A.L., 1996. J. Biol. Chem. 271, 27280. Wiertz, E.J., et al. 1996. Cell 84, 769. Jensen, T.J., et al. 1995. Cell 83, 129. Read, M.A., et al. 1995. Immunity 2, 493. Rock, K.L., et al. 1994. Cell 78, 761.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Proteases Inhibitors > Proteasome and Ubiquitination Pathway Inhibitors

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