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	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

444968 Sigma-AldrichInSolution™ MEK1/2 Inhibitor III, PD0325901 - CAS 391210-10-9 - Calbiochem

InSolution™ MEK1/2 Inhibitor III, PD0325901, CAS 391210-10-9, is a 50 mM solution of MEK1/2 Inhibitor III, PD0325901 in DMSO. A cell-permeable, potent, non-competitive MEK/MAPKK/MKK inhibitor.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
小册子
Data Sheet

同义词: PD 0325901, N-((2R)-2,3-Dihyroxypropoxy)-3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)-benzamide, PD325901

Recommended Products

概述

Replacement Information

重要规格表

CAS #	Empirical Formula
391210-10-9	C₁₆H₁₄F₃IN₂O₄

价格及供货情况

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Description
Overview	A cell-permeable benzamide compound that acts as a non-competitive, highly potent, selective MEK/MAPKK/MKK inhibitor and effectively blocks cellular Erk1/2 phosphorylation (by >90% in serum-starved HeLa after serum-stimulation and 50% in C26 with 25 and 0.33 nM inhibitor, respectively), while exhibiting little or no effect against the activity of Erk1/2 or a panel of 66 other kinases even at concentrations as high as 10 µM in cell-free kinase assays. Shown to be orally available in mice and suppress both the growth of and Erk phosphorylation in BRAF(V600E)-expressing SKMEL28 cell-derived tumor in vivo.
Catalogue Number	444968
Brand Family	Calbiochem®
Synonyms	PD 0325901, N-((2R)-2,3-Dihyroxypropoxy)-3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)-benzamide, PD325901

References
References	Barrett, S.D., et al. 2008. Bioorg. Med. Chem. Lett. 18, 6501. Leyton, J., et al. 2008. Mol. Cancer Ther. 7, 3112. Silva, J., et al. 2008. PLoS Biol. 6, 2237. Ying, Q.L., et al. 2008. Nature 453, 519. Bain, J., et al. 2007. Biochem. J. 408, 297. Solit, D.B., et al. 2006. Nature 439, 358.

Product Information
CAS number	391210-10-9
Form	Liquid
Formulation	A 50 mM (5 mg/207 µl) solution of MEK1/2 Inhibitor III, PD0325901 (Cat. No. 444966) in DMSO.
Hill Formula	C₁₆H₁₄F₃IN₂O₄
Chemical formula	C₁₆H₁₄F₃IN₂O₄
Hygroscopic	Hygroscopic
Structure formula Image
Quality Level	MQ100

Applications
Application	InSolution™ MEK1/2 Inhibitor III, PD0325901, CAS 391210-10-9, is a 50 mM solution of MEK1/2 Inhibitor III, PD0325901 in DMSO. A cell-permeable, potent, non-competitive MEK/MAPKK/MKK inhibitor.

Biological Information
Purity	≥95% by HPLC

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Dry Ice Only
Toxicity	Regulatory Review
Storage	-20°C
Protect from Light	Protect from light
Hygroscopic	Hygroscopic
Do not freeze	Ok to freeze
Special Instructions	Following initial thaw, aliquot and freeze (-20°C).

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
444968-5MGCN	04055977204544

Documentation

InSolution™ MEK1/2 Inhibitor III, PD0325901 - CAS 391210-10-9 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

InSolution™ MEK1/2 Inhibitor III, PD0325901 - CAS 391210-10-9 - Calbiochem 分析证书

标题	批号
444968	输入批号

参考

参考信息概述
Barrett, S.D., et al. 2008. Bioorg. Med. Chem. Lett. 18, 6501. Leyton, J., et al. 2008. Mol. Cancer Ther. 7, 3112. Silva, J., et al. 2008. PLoS Biol. 6, 2237. Ying, Q.L., et al. 2008. Nature 453, 519. Bain, J., et al. 2007. Biochem. J. 408, 297. Solit, D.B., et al. 2006. Nature 439, 358.

小册子

标题
New Products: Volume 3, 2012

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	03-April-2012 JSW
Synonyms	PD 0325901, N-((2R)-2,3-Dihyroxypropoxy)-3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)-benzamide, PD325901
Description	A cell-permeable benzamide compound that acts as a non-competitive, highly potent, selective MEK/MAPKK/MKK inhibitor and effectively blocks cellular Erk1/2 phosphorylation (by >90% in serum-starved HeLa after serum-stimulation and 50% in C26 with 25 and 0.33 nM inhibitor, respectively), while exhibiting little or no effect against the activity of Erk1/2 or a panel of 66 other kinases even at concentrations as high as 10 µM in cell-free kinase assays. Shown to be orally available in mice and suppress both the growth of and Erk phosphorylation in BRAF(V600E)-expressing SKMEL28 cell-derived tumor in vivo.
Form	Liquid
Formulation	A 50 mM (5 mg/207 µl) solution of MEK1/2 Inhibitor III, PD0325901 (Cat. No. 444966) in DMSO.
Intert gas (Yes/No)	Packaged under inert gas
CAS number	391210-10-9
Chemical formula	C₁₆H₁₄F₃IN₂O₄
Structure formula
Purity	≥95% by HPLC
Storage	Protect from light -20°C Hygroscopic
Do Not Freeze	Ok to freeze
Special Instructions	Following initial thaw, aliquot and freeze (-20°C).
Toxicity	Regulatory Review
References	Barrett, S.D., et al. 2008. Bioorg. Med. Chem. Lett. 18, 6501. Leyton, J., et al. 2008. Mol. Cancer Ther. 7, 3112. Silva, J., et al. 2008. PLoS Biol. 6, 2237. Ying, Q.L., et al. 2008. Nature 453, 519. Bain, J., et al. 2007. Biochem. J. 408, 297. Solit, D.B., et al. 2006. Nature 439, 358.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > MAP Kinase Inhibitors

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