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440204 Sigma-AldrichInSolution™ LY 294002 - CAS 154447-36-6 - Calbiochem

InSolution™ LY 294002, CAS 154447-36-6, is a 10 mM solution of LY 294002 (Cat. No. 440202) in DMSO. A cell-permeable, potent, reversible and specific inhibitor of PI 3-kinase (IC50 = 1.4 µM).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet
Citations

同义词: 2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one, BRD2 Inhibitor IV, BRD3 Inhibitor III, BRD4 Inhibitor IV

Primary Target: phosphatidylinositol 3-kinase

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概述

Replacement Information

重要规格表

CAS #	Empirical Formula
154447-36-6	C₁₉H₁₇NO₃

价格及供货情况

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Description
Catalogue Number	440204
Brand Family	Calbiochem®
Synonyms	2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one, BRD2 Inhibitor IV, BRD3 Inhibitor III, BRD4 Inhibitor IV

References
References	Dittman, A., et al. 2013. ACS Chem. Biol. 9, 495. Baumann, P., and West, S.C. 1998. Proc. Natl. Acad. Sci. USA 95, 14066. Cardone, M.H., et al. 1998. Science 282, 1318. Vlahos, C.J., et al. 1995. J. Immunol. 154, 2413. Yano, H., et al. 1995. Biochem. J. 312, 145. Vlahos, C.J., et al. 1994. J. Biol. Chem. 269, 5241. Selected Citations Lee, J., et al. 2009. Cell Stem Cell 5, 76.

References

Dittman, A., et al. 2013. ACS Chem. Biol. 9, 495.
Baumann, P., and West, S.C. 1998. Proc. Natl. Acad. Sci. USA 95, 14066.
Cardone, M.H., et al. 1998. Science 282, 1318.
Vlahos, C.J., et al. 1995. J. Immunol. 154, 2413.
Yano, H., et al. 1995. Biochem. J. 312, 145.
Vlahos, C.J., et al. 1994. J. Biol. Chem. 269, 5241.

Selected Citations
Lee, J., et al. 2009. Cell Stem Cell 5, 76.

Product Information
CAS number	154447-36-6
ATP Competitive	Y
Form	Liquid
Formulation	A 10 mM (1 mg/325 µl) solution of LY 294002 (Cat. No. 440202) in DMSO.
Hill Formula	C₁₉H₁₇NO₃
Chemical formula	C₁₉H₁₇NO₃
Reversible	Y
Structure formula Image
Quality Level	MQ100

Applications
Application	InSolution™ LY 294002, CAS 154447-36-6, is a 10 mM solution of LY 294002 (Cat. No. 440202) in DMSO. A cell-permeable, potent, reversible and specific inhibitor of PI 3-kinase (IC50 = 1.4 µM).

Biological Information
Primary Target	phosphatidylinositol 3-kinase
Primary Target IC<sub>50</sub>	1.4 µM against phosphatidylinositol 3-kinase
Purity	≥98% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information
R Phrase	R: 36/38 Irritating to eyes and skin.
S Phrase	S: 26-36-45 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).

Product Usage Statements

Storage and Shipping Information
Ship Code	Blue Ice Only
Toxicity	Irritant
Storage	-20°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following initial thaw, aliquot and freeze (-20°C).

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
440204-1MGCN	04055977186710

Documentation

InSolution™ LY 294002 - CAS 154447-36-6 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

InSolution™ LY 294002 - CAS 154447-36-6 - Calbiochem 分析证书

标题	批号
440204	输入批号

参考

参考信息概述
Dittman, A., et al. 2013. ACS Chem. Biol. 9, 495. Baumann, P., and West, S.C. 1998. Proc. Natl. Acad. Sci. USA 95, 14066. Cardone, M.H., et al. 1998. Science 282, 1318. Vlahos, C.J., et al. 1995. J. Immunol. 154, 2413. Yano, H., et al. 1995. Biochem. J. 312, 145. Vlahos, C.J., et al. 1994. J. Biol. Chem. 269, 5241. Selected Citations Lee, J., et al. 2009. Cell Stem Cell 5, 76.

参考信息概述

引用

标题

Ana Olivera, et al. (2006) IgE-dependent activation of sphingosine kinase 1 and 2 and secretion of sphingosine-1-phosphate requires Fyn kinase and contributes to mast cell responses. Journal of Biological Chemistry 281, 2515-2525.

Huanyu Dou, et al. (2005) Neuroprotective mechanisms of lithium in murine human immunodeficiency virus-1 encephalitis. Journal of Neuroscience 25, 8375-8385.

Julie Lotharius, et al. (2005) Progressive degeneration of human mesencephalic neuron-derived cells triggered by dopamine-dependent oxidative stress is dependent on the mixed lineage kinase pathway. Journal of Neuroscience 25, 6329-6342.

Meenalakshmi M. Mariappan, et al. (2005) Phospholipase Cγ-Erk Axis in Vascular Endothelial Growth Factor-Induced Eukaryotic Initiation Factor 4E Phosphorylation and Protein Synthesis in Renal Epithelial Cells. Journal of Biological Chemistry 280, 28402-28411.

Michael Tscharntke, et al. (2005) Ras-induced spreading and wound closure in human epidermal keratinocytes. The FASEB Journal in press,.

Junji Tsurutani, et al. (2005) Inhibition of the phosphatidylinositol 3-kinase/Akt/Mammalian target of rapamycin pathway but no the MEK/ERK Pathway attentuates laminin-meidated small cell lunch cancer cellular survival and resistance to Imatinib mesylate or chemolyte.. Cancer Research 65, 8423-8432.

Xinbo Liao, et al. (2003) Androgen stimulates matrix metalloproteinase-2 expression in human prostate cancer. Endocrinology 144, 1656-1663.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	06-August-2008 RFH
Synonyms	2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one, BRD2 Inhibitor IV, BRD3 Inhibitor III, BRD4 Inhibitor IV
Form	Liquid
Formulation	A 10 mM (1 mg/325 µl) solution of LY 294002 (Cat. No. 440202) in DMSO.
Intert gas (Yes/No)	Packaged under inert gas
CAS number	154447-36-6
Chemical formula	C₁₉H₁₇NO₃
Structure formula
Purity	≥98% by HPLC
Storage	Protect from light -20°C
Do Not Freeze	Ok to freeze
Special Instructions	Following initial thaw, aliquot and freeze (-20°C).
Toxicity	Irritant
References	Dittman, A., et al. 2013. ACS Chem. Biol. 9, 495. Baumann, P., and West, S.C. 1998. Proc. Natl. Acad. Sci. USA 95, 14066. Cardone, M.H., et al. 1998. Science 282, 1318. Vlahos, C.J., et al. 1995. J. Immunol. 154, 2413. Yano, H., et al. 1995. Biochem. J. 312, 145. Vlahos, C.J., et al. 1994. J. Biol. Chem. 269, 5241. Selected Citations Lee, J., et al. 2009. Cell Stem Cell 5, 76.
Citation	Ana Olivera, et al. (2006) IgE-dependent activation of sphingosine kinase 1 and 2 and secretion of sphingosine-1-phosphate requires Fyn kinase and contributes to mast cell responses. Journal of Biological Chemistry 281, 2515-2525. Huanyu Dou, et al. (2005) Neuroprotective mechanisms of lithium in murine human immunodeficiency virus-1 encephalitis. Journal of Neuroscience 25, 8375-8385. Julie Lotharius, et al. (2005) Progressive degeneration of human mesencephalic neuron-derived cells triggered by dopamine-dependent oxidative stress is dependent on the mixed lineage kinase pathway. Journal of Neuroscience 25, 6329-6342. Meenalakshmi M. Mariappan, et al. (2005) Phospholipase Cγ-Erk Axis in Vascular Endothelial Growth Factor-Induced Eukaryotic Initiation Factor 4E Phosphorylation and Protein Synthesis in Renal Epithelial Cells. Journal of Biological Chemistry 280, 28402-28411. Michael Tscharntke, et al. (2005) Ras-induced spreading and wound closure in human epidermal keratinocytes. The FASEB Journal in press,. Junji Tsurutani, et al. (2005) Inhibition of the phosphatidylinositol 3-kinase/Akt/Mammalian target of rapamycin pathway but no the MEK/ERK Pathway attentuates laminin-meidated small cell lunch cancer cellular survival and resistance to Imatinib mesylate or chemolyte.. Cancer Research 65, 8423-8432. Xinbo Liao, et al. (2003) Androgen stimulates matrix metalloproteinase-2 expression in human prostate cancer. Endocrinology 144, 1656-1663.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Phosphatidylinositol 3-Kinase (PI 3-kinase) Inhibitors

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