数量	产品目录编号	订购说明	数量 / 包装	公开价
			96-Well Plate

数量	产品目录编号	订购说明	数量 / 包装	公开价
	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

420297 Sigma-AldrichInSolution™ K-252a, Nocardiopsis sp. - CAS 97161-97-2 - Calbiochem

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet
Citations

Primary Target: CaM kinase II

Recommended Products

概述

Replacement Information

重要规格表

CAS #	Empirical Formula
97161-97-2	C₂₇H₂₁N₃O₅

价格及供货情况

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Description
Catalogue Number	420297
Brand Family	Calbiochem®

References
References	Chin, L.S., et al. 1999. Cancer Invest. 17, 391. Nakanishi, N., et al. 1995. FEBS Lett. 368, 411. Ross, A.H., et al. 1995. J. Neurochem. 65, 2748. Mizuno, K., et al. 1993. FEBS Lett. 330, 114. Pawlowska, Z., et al. 1993. J. Neurochem. 60, 678. Tapley, P., et al. 1992. Oncogene 7, 371. Simpson, D.L., et al. 1991. J. Neurosci. Res. 28, 486. Hashimoto, S. 1988. J. Cell Biol. 107, 1531. Koizuma, S., et al. 1988. J. Neurosci. 8, 715. Kase, H., et al. 1987. Biochem. Biophys. Res. Commun. 142, 436.

References

Chin, L.S., et al. 1999. Cancer Invest. 17, 391.
Nakanishi, N., et al. 1995. FEBS Lett. 368, 411.
Ross, A.H., et al. 1995. J. Neurochem. 65, 2748.
Mizuno, K., et al. 1993. FEBS Lett. 330, 114.
Pawlowska, Z., et al. 1993. J. Neurochem. 60, 678.
Tapley, P., et al. 1992. Oncogene 7, 371.
Simpson, D.L., et al. 1991. J. Neurosci. Res. 28, 486.
Hashimoto, S. 1988. J. Cell Biol. 107, 1531.
Koizuma, S., et al. 1988. J. Neurosci. 8, 715.
Kase, H., et al. 1987. Biochem. Biophys. Res. Commun. 142, 436.

Product Information
CAS number	97161-97-2
ATP Competitive	Y
Form	Liquid
Formulation	A 1 mM (100 µg/214 µl) solution of K-252a (Cat. No. 420298) in DMSO.
Hill Formula	C₂₇H₂₁N₃O₅
Chemical formula	C₂₇H₂₁N₃O₅
Hygroscopic	Hygroscopic
Reversible	Y
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	CaM kinase II
Primary Target K<sub>i</sub>	1.8 nM, 20 nM, 18 nM, 25 nM, 20 nM, 3 nM, against CaM kinase II, myosin light chain kinase, protein kinase A, protein kinase C, protein kinase G, NGF receptor gp140trk, respectively
Purity	≥95% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information
R Phrase	R: 36/38 Irritating to eyes and skin.
S Phrase	S: 26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.

Product Usage Statements

Storage and Shipping Information
Ship Code	Blue Ice Only
Toxicity	Irritant
Storage	-20°C
Protect from Light	Protect from light
Hygroscopic	Hygroscopic
Do not freeze	Ok to freeze
Special Instructions	Following initial thaw aliquot and freeze at (-20°C). Store under an inert atmosphere.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
420297-100UGCN	04055977210903

Documentation

InSolution™ K-252a, Nocardiopsis sp. - CAS 97161-97-2 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

InSolution™ K-252a, Nocardiopsis sp. - CAS 97161-97-2 - Calbiochem 分析证书

标题	批号
420297	输入批号

参考

参考信息概述
Chin, L.S., et al. 1999. Cancer Invest. 17, 391. Nakanishi, N., et al. 1995. FEBS Lett. 368, 411. Ross, A.H., et al. 1995. J. Neurochem. 65, 2748. Mizuno, K., et al. 1993. FEBS Lett. 330, 114. Pawlowska, Z., et al. 1993. J. Neurochem. 60, 678. Tapley, P., et al. 1992. Oncogene 7, 371. Simpson, D.L., et al. 1991. J. Neurosci. Res. 28, 486. Hashimoto, S. 1988. J. Cell Biol. 107, 1531. Koizuma, S., et al. 1988. J. Neurosci. 8, 715. Kase, H., et al. 1987. Biochem. Biophys. Res. Commun. 142, 436.

参考信息概述

引用

标题

Huanyu Dou, et al. (2005) Neuroprotective mechanisms of lithium in murine human immunodeficiency virus-1 encephalitis. Journal of Neuroscience 25, 8375-8385.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	30-July-2008 JSW
Description	A cell-permeable protein kinase inhibitor that inhibits CaM kinase II (K_i = 1.8 nM), myosin light chain kinase (K_i = 17 nM), protein kinase A (K_i = 18 nM), protein kinase C (K_i = 25 nM), and protein kinase G (K_i = 20 nM). Also acts as a potent inhibitor (IC₅₀ = 3 nM) of the tyrosine protein kinase activity of the NGF receptor gp 140trk, the product of the trk protooncogene. Also inhibits the kinase activity of its transforming alleles, the trk oncogenes, and of the related neurotrophin receptors gp 145trkB and gp 145trkC. Induces apoptosis and cell cycle arrest by inhibiting Cdc2 and Cdc25c.
Form	Liquid
Formulation	A 1 mM (100 µg/214 µl) solution of K-252a (Cat. No. 420298) in DMSO.
Intert gas (Yes/No)	Packaged under inert gas
CAS number	97161-97-2
Chemical formula	C₂₇H₂₁N₃O₅
Structure formula
Purity	≥95% by HPLC
Storage	Protect from light -20°C Hygroscopic
Do Not Freeze	Ok to freeze
Special Instructions	Following initial thaw aliquot and freeze at (-20°C). Store under an inert atmosphere.
Toxicity	Irritant
References	Chin, L.S., et al. 1999. Cancer Invest. 17, 391. Nakanishi, N., et al. 1995. FEBS Lett. 368, 411. Ross, A.H., et al. 1995. J. Neurochem. 65, 2748. Mizuno, K., et al. 1993. FEBS Lett. 330, 114. Pawlowska, Z., et al. 1993. J. Neurochem. 60, 678. Tapley, P., et al. 1992. Oncogene 7, 371. Simpson, D.L., et al. 1991. J. Neurosci. Res. 28, 486. Hashimoto, S. 1988. J. Cell Biol. 107, 1531. Koizuma, S., et al. 1988. J. Neurosci. 8, 715. Kase, H., et al. 1987. Biochem. Biophys. Res. Commun. 142, 436.
Citation	Huanyu Dou, et al. (2005) Neuroprotective mechanisms of lithium in murine human immunodeficiency virus-1 encephalitis. Journal of Neuroscience 25, 8375-8385.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Protein Kinase C (PKC) Inhibitors

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Myosin Light Chain Kinase (MLCK) Inhibitors

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Protein Kinase A (PKA; cAMP-Dependent Protein Kinase) Inhibitors

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Protein Kinase G (PKG; cGMP-Dependent Protein Kinase) Inhibitors

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Calmodulin-Dependent Protein Kinase (CaM Kinase) Inhibitors

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