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	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

420128 Sigma-AldrichInSolution™ JNK Inhibitor II - Calbiochem

The InSolution™ JNK Inhibitor II, also referenced under CAS 129-56-6, controls the biological activity of JNK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

InSolution™ JNK Inhibitor II - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

Primary Target: JNK 1, JNK 2, JNK 3

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概述

Replacement Information

重要规格表

Empirical Formula
C₁₄H₈N₂O

价格及供货情况

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Description
Catalogue Number	420128
Brand Family	Calbiochem®

References
References	Bennett, B.L., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 13681. Han, Z., et al. 2001. J. Clin. Invest. 108, 73.

Product Information
ATP Competitive	Y
Form	Yellowish brown liquid
Formulation	A 50 mM (5 mg/454 µl) solution of JNK Inhibitor II (Cat. No. 420119) in DMSO.
Hill Formula	C₁₄H₈N₂O
Chemical formula	C₁₄H₈N₂O
Hygroscopic	Hygroscopic
Reversible	Y
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	JNK 1, JNK 2, JNK 3
Primary Target IC<sub>50</sub>	40 nM for JNK-1 and JNK-2 and 90 nM for JNK-3
Purity	≥98% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Blue Ice Only
Toxicity	Irritant
Storage	-20°C
Protect from Light	Protect from light
Hygroscopic	Hygroscopic
Do not freeze	Ok to freeze
Special Instructions	Following initial use, aliquot and refrigerate (4°C) for short-term storage or freeze (-20°C) for long-term storage.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
420128-5MGCN	04055977188066

Documentation

InSolution™ JNK Inhibitor II - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

InSolution™ JNK Inhibitor II - Calbiochem 分析证书

标题	批号
420128	输入批号

参考

参考信息概述
Bennett, B.L., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 13681. Han, Z., et al. 2001. J. Clin. Invest. 108, 73.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	24-July-2008 RFH
Description	A potent, cell-permeable, selective, and reversible inhibitor of c-Jun N-terminal kinase (JNK) (IC₅₀ = 40 nM for JNK-1 and JNK-2 and 90 nM for JNK-3). The inhibition is competitive with respect to ATP. Exhibits over 300-fold greater selectivity for JNK as compared to ERK1 and p38-2 MAP kinases. Inhibits the phosphorylation of c-Jun and blocks the expression of IL-2, IFN-γ, TNF-α, and COX-2 in cells. Blocks IL-1-induced accumulation of phospho-Jun and induction of c-Jun transcription.
Form	Yellowish brown liquid
Formulation	A 50 mM (5 mg/454 µl) solution of JNK Inhibitor II (Cat. No. 420119) in DMSO.
Intert gas (Yes/No)	Packaged under inert gas
Chemical formula	C₁₄H₈N₂O
Structure formula
Purity	≥98% by HPLC
Storage	Protect from light -20°C Hygroscopic
Do Not Freeze	Ok to freeze
Special Instructions	Following initial use, aliquot and refrigerate (4°C) for short-term storage or freeze (-20°C) for long-term storage.
Toxicity	Irritant
References	Bennett, B.L., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 13681. Han, Z., et al. 2001. J. Clin. Invest. 108, 73.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > c-Jun N-Terminal Kinase (JNK/SAP Kinase) Inhibitors

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