数量	产品目录编号	订购说明	数量 / 包装	公开价
			96-Well Plate

数量	产品目录编号	订购说明	数量 / 包装	公开价
	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

401484 Sigma-AldrichInSolution™ IKK-2 Inhibitor IV - Calbiochem

The InSolution™ IKK-2 Inhibitor IV controls the biological activity of IKK-2. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.

InSolution™ IKK-2 Inhibitor IV - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

Primary Target: IKK-2

View Products on Sigmaaldrich.com

Recommended Products

概述

Replacement Information

重要规格表

Empirical Formula
C₁₂H₁₀FN₃O₂S

价格及供货情况

产品目录编号	库存情况	包装	数量 / 包装	价格	数量
401484-500UGCN	正在查询供货情况...... — 目前缺货有货停产少量现货供货情况有待确认登录查看库存有货目前缺货有货其余：另行通知其余：另行通知另行通知联系客户服务 Contact Customer Service 联系客户服务联系客户服务	塑胶安瓿;塑胶针药瓶	500 μg	正在检索价格...... 无法检索价格。最小订购数量为倍数 Maximum Quantity is 以订单确认为准更多信息您节约了 ()。 — Request Pricing 登录查看价格	查看库存情况 —	添加到收藏夹添加到收藏夹添加到我的收藏夹

Description
Catalogue Number	401484
Brand Family	Calbiochem®

References
References	Podolin, P.L., et al. 2005. J. Pharmacol. Exp. Ther. 312, 373. Karin, M., et al. 2004. Nat. Rev. Drug Discov. 3, 17. Roshak, A.K., et al. 2002. Inflamm. Res. 51, S4.

Product Information
ATP Competitive	Y
Form	Clear pale yellow Liquid
Formulation	A 10 mM (500 µg/179 µl) solution of IKK-2 Inhibitor IV (Cat. No. 401481) in DMSO.
Hill Formula	C₁₂H₁₀FN₃O₂S
Chemical formula	C₁₂H₁₀FN₃O₂S
Hygroscopic	Hygroscopic
Reversible	Y
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	IKK-2
Primary Target IC<sub>50</sub>	18 nM
Purity	≥95% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Shipped with Blue Ice or with Dry Ice
Toxicity	Irritant
Storage	+2°C to +8°C
Protect from Light	Protect from light
Hygroscopic	Hygroscopic
Do not freeze	Ok to freeze
Special Instructions	Following initial use, aliquot and refrigerate (4°C).

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
401484-500UGCN	04055977211993

Documentation

InSolution™ IKK-2 Inhibitor IV - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

InSolution™ IKK-2 Inhibitor IV - Calbiochem 分析证书

标题	批号
401484	输入批号

参考

参考信息概述
Podolin, P.L., et al. 2005. J. Pharmacol. Exp. Ther. 312, 373. Karin, M., et al. 2004. Nat. Rev. Drug Discov. 3, 17. Roshak, A.K., et al. 2002. Inflamm. Res. 51, S4.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	14-July-2008 RFH
Description	IKK-2 Inhibitor IV (Cat. No. 401481) supplied in DMSO. A cell-permeable and potent inhibitor of IKK-2 (IC₅₀ = 18 nM) that exhibits selectivity over IKK-1, JNK, and p38 MAPK. Inhibits TNF-α production in human monocytes (IC₅₀ in the range of 0.15-2.5 µM) and blocks IL-8 and IL-6 production by synovial fibroblasts (IC₅₀ = 100 nM). Shown to reduce paw oedema in rat arthritis model (~100% inhibition at a dose of 30 mg/kg).
Form	Clear pale yellow Liquid
Formulation	A 10 mM (500 µg/179 µl) solution of IKK-2 Inhibitor IV (Cat. No. 401481) in DMSO.
Intert gas (Yes/No)	Packaged under inert gas
Chemical formula	C₁₂H₁₀FN₃O₂S
Structure formula
Purity	≥95% by HPLC
Storage	Protect from light +2°C to +8°C Hygroscopic
Do Not Freeze	Ok to freeze
Special Instructions	Following initial use, aliquot and refrigerate (4°C).
Toxicity	Irritant
References	Podolin, P.L., et al. 2005. J. Pharmacol. Exp. Ther. 312, 373. Karin, M., et al. 2004. Nat. Rev. Drug Discov. 3, 17. Roshak, A.K., et al. 2002. Inflamm. Res. 51, S4.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > NF-κB Activation

此产品已添加到您的购物车。