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			96-Well Plate

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	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

361552 Sigma-AldrichInSolution™ GSK-3 Inhibitor IX - CAS 667463-62-9 - Calbiochem

The InSolution™ GSK-3 Inhibitor IX, also referenced under CAS 667463-62-9, controls the biological activity of GSK-3. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

Primary Target: GSK-3α/β

Recommended Products

概述

Replacement Information

重要规格表

CAS #	Empirical Formula
667463-62-9	C₁₆H₁₀BrN₃O₂

价格及供货情况

产品目录编号	库存情况	包装	数量 / 包装	价格	数量
361552-500UGCN	正在查询供货情况...... — 目前缺货有货停产少量现货供货情况有待确认登录查看库存有货目前缺货有货其余：另行通知其余：另行通知另行通知联系客户服务 Contact Customer Service 联系客户服务联系客户服务	塑胶安瓿;塑胶针药瓶	500 μg	正在检索价格...... 无法检索价格。最小订购数量为倍数 Maximum Quantity is 以订单确认为准更多信息您节约了 ()。 — Request Pricing 登录查看价格	查看库存情况 —	添加到收藏夹添加到收藏夹添加到我的收藏夹

Description
Catalogue Number	361552
Brand Family	Calbiochem®

References
References	Polychronopoulos, P., et al. 2004. J. Med. Chem. 47, 935. Sato, N., et al. 2004. Nat. Med. 10, 55. Meijer, L., et al. 2003. Chem. Biol. 10, 1255.

Product Information
CAS number	667463-62-9
ATP Competitive	Y
Form	Liquid
Formulation	A 10 mM (500 µg/140 µl) solution of GSK-3 Inhibitor IX (Cat. No. 361550) in DMSO.
Hill Formula	C₁₆H₁₀BrN₃O₂
Chemical formula	C₁₆H₁₀BrN₃O₂
Hygroscopic	Hygroscopic
Reversible	N
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	GSK-3α/β
Primary Target IC<sub>50</sub>	5 nM against GSK-3α/β
Purity	≥97% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Shipped with Blue Ice or with Dry Ice
Toxicity	Carcinogenic / Teratogenic
Storage	+2°C to +8°C
Protect from Light	Protect from light
Hygroscopic	Hygroscopic
Do not freeze	Ok to freeze
Special Instructions	Following initial use, aliquot and refrigerate (4°C).

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
361552-500UGCN	04055977214109

Documentation

InSolution™ GSK-3 Inhibitor IX - CAS 667463-62-9 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

InSolution™ GSK-3 Inhibitor IX - CAS 667463-62-9 - Calbiochem 分析证书

标题	批号
361552	输入批号

参考

参考信息概述
Polychronopoulos, P., et al. 2004. J. Med. Chem. 47, 935. Sato, N., et al. 2004. Nat. Med. 10, 55. Meijer, L., et al. 2003. Chem. Biol. 10, 1255.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	31-March-2008 JSW
Description	A cell-permeable, highly potent, selective, reversible, and ATP-competitive inhibitor of GSK-3α/β (IC₅₀ = 5 nM). Specificity was confirmed using various Cdk's (IC₅₀ = 83 nM for Cdk5/p25, 300 nM for Cdk2/cyclin A, 320 nM for Cdk1/cyclin B, and 10 µM for Cdk4/cyclin D1), MAP kinases, PKA, PKC isoforms, PKG, CK, and IRTK (IC₅₀ ≥ 10 µM). Inhibition of GSK by BIO has been shown to result in the activation of the Wnt signaling pathway and sustained pluripotency of human and murine embryonic stem cells (ESCs).
Form	Liquid
Formulation	A 10 mM (500 µg/140 µl) solution of GSK-3 Inhibitor IX (Cat. No. 361550) in DMSO.
Intert gas (Yes/No)	Packaged under inert gas
CAS number	667463-62-9
Chemical formula	C₁₆H₁₀BrN₃O₂
Structure formula
Purity	≥97% by HPLC
Storage	Protect from light +2°C to +8°C Hygroscopic
Do Not Freeze	Ok to freeze
Special Instructions	Following initial use, aliquot and refrigerate (4°C).
Toxicity	Carcinogenic / Teratogenic
References	Polychronopoulos, P., et al. 2004. J. Med. Chem. 47, 935. Sato, N., et al. 2004. Nat. Med. 10, 55. Meijer, L., et al. 2003. Chem. Biol. 10, 1255.

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描述

361550

GSK-3 Inhibitor IX - CAS 667463-62-9 - Calbiochem

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产品目录编号	库存情况	包装	数量 / 包装	价格	数量
361550-10MGCN	正在查询供货情况...... — 目前缺货有货停产少量现货供货情况有待确认登录查看库存有货目前缺货有货其余：另行通知其余：另行通知另行通知联系客户服务 Contact Customer Service 联系客户服务联系客户服务	塑胶安瓿;塑胶针药瓶	10 mg	正在检索价格...... 无法检索价格。最小订购数量为倍数 Maximum Quantity is 以订单确认为准更多信息您节约了 ()。 — Request Pricing 登录查看价格	查看库存情况 —	添加到收藏夹添加到收藏夹添加到我的收藏夹
361550-1MGCN	正在查询供货情况...... — 目前缺货有货停产少量现货供货情况有待确认登录查看库存有货目前缺货有货其余：另行通知其余：另行通知另行通知联系客户服务 Contact Customer Service 联系客户服务联系客户服务	塑胶安瓿;塑胶针药瓶	1 mg	正在检索价格...... 无法检索价格。最小订购数量为倍数 Maximum Quantity is 以订单确认为准更多信息您节约了 ()。 — Request Pricing 登录查看价格	查看库存情况 —	添加到收藏夹添加到收藏夹添加到我的收藏夹
361550-30MGCN	正在查询供货情况...... — 目前缺货有货停产少量现货供货情况有待确认登录查看库存有货目前缺货有货其余：另行通知其余：另行通知另行通知联系客户服务 Contact Customer Service 联系客户服务联系客户服务	塑胶安瓿;塑胶针药瓶	30 mg	正在检索价格...... 无法检索价格。最小订购数量为倍数 Maximum Quantity is 以订单确认为准更多信息您节约了 ()。 — Request Pricing 登录查看价格	查看库存情况 —	添加到收藏夹添加到收藏夹添加到我的收藏夹

361556

GSK-3 Inhibitor IX, Control, MeBIO - CAS 710323-61-8 - Calbiochem

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种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Glycogen Synthase Kinase (GSK) Inhibitors

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Cell Cycle/Cell Division > Cyclin-Dependent Kinase (Cdk) Inhibitors

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