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	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

364206 Sigma-AldrichInSolution™ GM 6001 - Calbiochem

InSolution™ GM 6001, CAS 142880-36-2, is a 10 mM (1 mg/257 µl) solution of GM6001 in DMSO. A potent, cell-permeable, broad-spectrum inhibitor of MMPs.

InSolution™ GM 6001 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet
Citations

Primary Target: MMP-1

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概述

Replacement Information

重要规格表

Empirical Formula
C₂₀H₂₈N₄O₄

价格及供货情况

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Description
Catalogue Number	364206
Brand Family	Calbiochem®

References
References	Solorzano, C.C., et al. 1997. Shock 7, 427. Galardy, R.E., et al. 1994. Ann. NY Acad. Sci. 732, 315. Galardy, R.E., et al. 1994. Cancer Res. 54, 4715. Galardy, R.E., et al. 1993. Drugs Future 18, 1109. Grobelny, D., et al. 1992. Biochemistry 31, 7152.

Product Information
ATP Competitive	N
Form	Liquid
Formulation	A 10 mM (1 mg/257 µl) solution of GM6001 (Cat. No. 364205) in DMSO.
Hill Formula	C₂₀H₂₈N₄O₄
Chemical formula	C₂₀H₂₈N₄O₄
Hygroscopic	Hygroscopic
Reversible	N
Quality Level	MQ100

Applications
Application	InSolution™ GM 6001, CAS 142880-36-2, is a 10 mM (1 mg/257 µl) solution of GM6001 in DMSO. A potent, cell-permeable, broad-spectrum inhibitor of MMPs.

Biological Information
Primary Target	MMP-1
Primary Target K<sub>i</sub>	400 pM for MMP-1; 500 pM for MMP-2; 27 nM for MMP-3; 100 pM for MMP-8; and 200 pM for MMP-9
Purity	≥95% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Shipped with Blue Ice or with Dry Ice
Toxicity	Irritant
Storage	+2°C to +8°C
Protect from Light	Protect from light
Hygroscopic	Hygroscopic
Do not freeze	Ok to freeze
Special Instructions	Following initial use, aliquot and refrigerate (4°C).

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
364206-1MGCN	04055977213812

Documentation

InSolution™ GM 6001 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

InSolution™ GM 6001 - Calbiochem 分析证书

标题	批号
364206	输入批号

参考

参考信息概述
Solorzano, C.C., et al. 1997. Shock 7, 427. Galardy, R.E., et al. 1994. Ann. NY Acad. Sci. 732, 315. Galardy, R.E., et al. 1994. Cancer Res. 54, 4715. Galardy, R.E., et al. 1993. Drugs Future 18, 1109. Grobelny, D., et al. 1992. Biochemistry 31, 7152.

引用

标题

K. Fredriksson, et al. (2006) Red blood cells increase secretion of matrix metalloproteinases from human lung fibroblasts in vitro. American Journal of Physiology Lung Cellular and Molecular Physiology 290, L326-L333.

Daniel W. Lambert, et al. (2005) Tumor Necrosis Factor- Convertase (ADAM17) Mediates Regulated Ectodomain Shedding of the Severe-acute Respiratory Syndrome-Coronavirus (SARS-CoV) Receptor, Angiotensin-converting Enzyme-2 (ACE2). Journal of Biological Chemistry 280, 30113-30119.

Haili Su, et al. (2005) Noninvasive targeted imaging of matrix metalloproteinase activation in a murine model of postinfarction remodeling. Circulation 112, 3157-3167.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	02-July-2008 RFH
Description	A potent broad-spectrum hydroxamic acid inhibitor of matrix metalloproteinases (MMPs). Inhibits MMPs in vitro [K_i = 0.4 nM for skin fibroblast collagenase (MMP-1); K_i = 0.5 nM for gelatinase A (MMP-2); K_i = 27 nM for stromelysin (MMP-3); K_i = 0.1 nM for neutrophil collagenase (MMP-8); and K_i = 0.2 nM for gelatinase B (MMP-9)]. Also prevents the release of TNF-α in vivo and in vitro and abrogates endotoxin-induced lethality in mice.
Form	Liquid
Formulation	A 10 mM (1 mg/257 µl) solution of GM6001 (Cat. No. 364205) in DMSO.
Intert gas (Yes/No)	Packaged under inert gas
Chemical formula	C₂₀H₂₈N₄O₄
Purity	≥95% by HPLC
Storage	Protect from light +2°C to +8°C Hygroscopic
Do Not Freeze	Ok to freeze
Special Instructions	Following initial use, aliquot and refrigerate (4°C).
Toxicity	Irritant
References	Solorzano, C.C., et al. 1997. Shock 7, 427. Galardy, R.E., et al. 1994. Ann. NY Acad. Sci. 732, 315. Galardy, R.E., et al. 1994. Cancer Res. 54, 4715. Galardy, R.E., et al. 1993. Drugs Future 18, 1109. Grobelny, D., et al. 1992. Biochemistry 31, 7152.
Citation	K. Fredriksson, et al. (2006) Red blood cells increase secretion of matrix metalloproteinases from human lung fibroblasts in vitro. American Journal of Physiology Lung Cellular and Molecular Physiology 290, L326-L333. Daniel W. Lambert, et al. (2005) Tumor Necrosis Factor- Convertase (ADAM17) Mediates Regulated Ectodomain Shedding of the Severe-acute Respiratory Syndrome-Coronavirus (SARS-CoV) Receptor, Angiotensin-converting Enzyme-2 (ACE2). Journal of Biological Chemistry 280, 30113-30119. Haili Su, et al. (2005) Noninvasive targeted imaging of matrix metalloproteinase activation in a murine model of postinfarction remodeling. Circulation 112, 3157-3167.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Proteases Inhibitors > Matrix Metalloproteinase (MMP) Inhibitors

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