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			96-Well Plate

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	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

365253 Sigma-AldrichInSolution™ Gö 6976 - CAS 136194-77-9 - Calbiochem

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet
Citations

同义词: Go 6976, Solution, 12-(2-Cyanoethyl)-6,7,12,13-tetrahydro-13-methyl-5-oxo-5H-indolo(2,3-a)pyrrolo(3,4-c)-carbazole

Primary Target: PKC

Recommended Products

概述

Replacement Information

重要规格表

CAS #	Empirical Formula
136194-77-9	C₂₄H₁₈N₄O

价格及供货情况

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Description
Catalogue Number	365253
Brand Family	Calbiochem®
Synonyms	Go 6976, Solution, 12-(2-Cyanoethyl)-6,7,12,13-tetrahydro-13-methyl-5-oxo-5H-indolo(2,3-a)pyrrolo(3,4-c)-carbazole

References
References	Gschwendt, M., et al. 1996. FEBS Lett. 392, 77. Wenzel-Seifert, K., et al. 1994. Biochem. Biophys. Res. Commun. 200, 1536. Martiny-Baron, G., et al. 1993. J. Biol. Chem. 268, 9194. Qatsha, K.A., et al. 1993. Proc. Natl. Acad. Sci. USA 90, 674.

Product Information
CAS number	136194-77-9
ATP Competitive	Y
Form	Liquid
Formulation	A 500 µg/ml solution of Gö 6976 (Cat. No. 365250) in anhydrous DMSO.
Hill Formula	C₂₄H₁₈N₄O
Chemical formula	C₂₄H₁₈N₄O
Reversible	Y
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	PKC
Primary Target IC<sub>50</sub>	7.9 nM, 2.3 nM, and 6.2 nM, for rat brain PKC, Ca2+-dependent PKC α-isozyme, and PKCβI, respectively
Purity	≥95% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information
R Phrase	R: 36/38 Irritating to eyes and skin.
S Phrase	S: 26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.

Product Usage Statements

Storage and Shipping Information
Ship Code	Blue Ice Only
Toxicity	Irritant
Storage	-20°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following initial thaw, aliquot and freeze (-20°C).

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
365253-1MLCN	04055977192056

Documentation

InSolution™ Gö 6976 - CAS 136194-77-9 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

InSolution™ Gö 6976 - CAS 136194-77-9 - Calbiochem 分析证书

标题	批号
365253	输入批号

参考

参考信息概述
Gschwendt, M., et al. 1996. FEBS Lett. 392, 77. Wenzel-Seifert, K., et al. 1994. Biochem. Biophys. Res. Commun. 200, 1536. Martiny-Baron, G., et al. 1993. J. Biol. Chem. 268, 9194. Qatsha, K.A., et al. 1993. Proc. Natl. Acad. Sci. USA 90, 674.

引用

标题

Justin C. Mason, et al. (2004) Decay-accelerating actor induction on vascular endothelium by vascular endothelial growth factor (VEGF) is mediated via a VEGF receptor-2 (VEGF-R2)- and protein kinase C-α/ε (PKCα/ε)-dependent cytoprotective signaling pathway a. Journal of Biological Chemistry 279, 41611-41618.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	02-July-2008 RFH
Synonyms	Go 6976, Solution, 12-(2-Cyanoethyl)-6,7,12,13-tetrahydro-13-methyl-5-oxo-5H-indolo(2,3-a)pyrrolo(3,4-c)-carbazole
Description	Inhibitor of protein kinase C (PKC; IC₅₀ = 7.9 nM for rat brain). Selectively inhibits Ca²⁺-dependent PKC_α-isozyme (IC₅₀ = 2.3 nM) and PKC_βI (IC₅₀ = 6.2 nM). Does not affect the kinase activity of the Ca²⁺-independent PKC δ-, ε-, and ζ-isoenzymes even at micromolar levels. A potent antagonist of HIV-1 induction.
Form	Liquid
Formulation	A 500 µg/ml solution of Gö 6976 (Cat. No. 365250) in anhydrous DMSO.
Intert gas (Yes/No)	Packaged under inert gas
CAS number	136194-77-9
Chemical formula	C₂₄H₁₈N₄O
Structure formula
Purity	≥95% by HPLC
Solubility	DMSO (5 mg/ml)
Storage	Protect from light -20°C
Do Not Freeze	Ok to freeze
Special Instructions	Following initial thaw, aliquot and freeze (-20°C).
Toxicity	Irritant
References	Gschwendt, M., et al. 1996. FEBS Lett. 392, 77. Wenzel-Seifert, K., et al. 1994. Biochem. Biophys. Res. Commun. 200, 1536. Martiny-Baron, G., et al. 1993. J. Biol. Chem. 268, 9194. Qatsha, K.A., et al. 1993. Proc. Natl. Acad. Sci. USA 90, 674.
Citation	Justin C. Mason, et al. (2004) Decay-accelerating actor induction on vascular endothelium by vascular endothelial growth factor (VEGF) is mediated via a VEGF receptor-2 (VEGF-R2)- and protein kinase C-α/ε (PKCα/ε)-dependent cytoprotective signaling pathway a. Journal of Biological Chemistry 279, 41611-41618.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Protein Kinase C (PKC) Inhibitors

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