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			96-Well Plate

数量	产品目录编号	订购说明	数量 / 包装	公开价
	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

239806 Sigma-AldrichInSolution™ Cyclopamine, V. californicum - Calbiochem

The InSolution™ Cyclopamine, V. californicum controls the biological activity of Sonic Hedgehog signaling pathway. This small molecule/inhibitor is primarily used for Cancer applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: Shh Signaling Antagonist I in EtOH

Recommended Products

概述

Replacement Information

重要规格表

Empirical Formula
C₂₇H₄₁NO₂

价格及供货情况

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Description
Overview	A cell-permeable steroidal alkaloid and cholesterol mimic that displays both teratogenic and antitumor activities. It disrupts cholesterol bio-synthesis and specifically antagonizes shh (Sonic Hedgehog) signaling pathway through direct interaction with Smo (smoothened), a distant relative of G-protein-coupled receptors. A valuable tool for studying the involvement of shh signaling in the development of various tumors. Tomatidine (Cat. No. 614350) can be used as a negative control. The solid form of this compound (Cat. No. 239803) is also available.
Catalogue Number	239806
Brand Family	Calbiochem®
Synonyms	Shh Signaling Antagonist I in EtOH

References
References	Berman, D.M., et al. 2003. Nature, 425, 846. Thayer, S.P., et al. 2003. Nature, 425, 851. Watkins, D.N., et al. 2003. Nature 422, 313. Chen, J.K., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 14071. Berman, D.M., et al. 2002. Science 297, 1559. Taipale, J., et al. 2000. Nature 406, 1005. Kim, S.K., and Melton, D.A. 1998. Proc. Natl. Acad. Sci. USA 95, 13036. Cooper, M.K., et al. 1998. Science 280, 1603. Incardona, J.P., et al. 1998. Development 125, 3553.

References

Berman, D.M., et al. 2003. Nature, 425, 846.
Thayer, S.P., et al. 2003. Nature, 425, 851.
Watkins, D.N., et al. 2003. Nature 422, 313.
Chen, J.K., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 14071.
Berman, D.M., et al. 2002. Science 297, 1559.
Taipale, J., et al. 2000. Nature 406, 1005.
Kim, S.K., and Melton, D.A. 1998. Proc. Natl. Acad. Sci. USA 95, 13036.
Cooper, M.K., et al. 1998. Science 280, 1603.
Incardona, J.P., et al. 1998. Development 125, 3553.

Product Information
Form	Liquid
Formulation	Supplied as a 10 mM (5 mg/1.22 mL) solution of Cyclopamine, V. californicum (Cat. No. 239803) in EtOH.
Hill Formula	C₂₇H₄₁NO₂
Chemical formula	C₂₇H₄₁NO₂
Hygroscopic	Hygroscopic
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Purity	≥97% by NMR

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information
R Phrase	R: 10 Flammable.
S Phrase	S: 16-7 Keep away from sources of ignition - No Smoking. Keep container tightly closed.

Product Usage Statements

Storage and Shipping Information
Ship Code	Dry Ice Only
Toxicity	Flammable
Hazardous Materials Attention:	Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage	≤ -70°C
Protect from Light	Protect from light
Hygroscopic	Hygroscopic
Avoid freeze/thaw	Avoid freeze/thaw
Do not freeze	Ok to freeze
Special Instructions	Following initial thaw, aliquot and freeze (-70°C).

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
239806-5MGCN	04055977198911

Documentation

InSolution™ Cyclopamine, V. californicum - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

InSolution™ Cyclopamine, V. californicum - Calbiochem 分析证书

标题	批号
239806	输入批号

参考

参考信息概述
Berman, D.M., et al. 2003. Nature, 425, 846. Thayer, S.P., et al. 2003. Nature, 425, 851. Watkins, D.N., et al. 2003. Nature 422, 313. Chen, J.K., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 14071. Berman, D.M., et al. 2002. Science 297, 1559. Taipale, J., et al. 2000. Nature 406, 1005. Kim, S.K., and Melton, D.A. 1998. Proc. Natl. Acad. Sci. USA 95, 13036. Cooper, M.K., et al. 1998. Science 280, 1603. Incardona, J.P., et al. 1998. Development 125, 3553.

参考信息概述

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	08-June-2012 JSW
Synonyms	Shh Signaling Antagonist I in EtOH
Description	A cell-permeable steroidal alkaloid and cholesterol mimic that displays both teratogenic and antitumor activities. It disrupts cholesterol bio-synthesis and specifically antagonizes shh (Sonic Hedgehog) signaling pathway through direct interaction with Smo (smoothened), a distant relative of G-protein-coupled receptors. A valuable tool for studying the involvement of shh signaling in the development of various tumors. Tomatidine (Cat. No. 614350) can be used as a negative control. The solid form of this compound (Cat. No. 239803) is also available.
Form	Liquid
Formulation	Supplied as a 10 mM (5 mg/1.22 mL) solution of Cyclopamine, V. californicum (Cat. No. 239803) in EtOH.
Intert gas (Yes/No)	Packaged under inert gas
Chemical formula	C₂₇H₄₁NO₂
Structure formula
Purity	≥97% by NMR
Storage	Protect from light Avoid freeze/thaw ≤ -70°C Hygroscopic
Do Not Freeze	Ok to freeze
Special Instructions	Following initial thaw, aliquot and freeze (-70°C).
Toxicity	Flammable
References	Berman, D.M., et al. 2003. Nature, 425, 846. Thayer, S.P., et al. 2003. Nature, 425, 851. Watkins, D.N., et al. 2003. Nature 422, 313. Chen, J.K., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 14071. Berman, D.M., et al. 2002. Science 297, 1559. Taipale, J., et al. 2000. Nature 406, 1005. Kim, S.K., and Melton, D.A. 1998. Proc. Natl. Acad. Sci. USA 95, 13036. Cooper, M.K., et al. 1998. Science 280, 1603. Incardona, J.P., et al. 1998. Development 125, 3553.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Stem Cell Biology > Sonic Hedgehog Signaling Inhibitors

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