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			96-Well Plate

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	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

239807 Sigma-AldrichInSolution™ Cyclopamine-KAAD - Calbiochem

InSolution™ Cyclopamine-KAAD, CAS 306387-90-6, is a 1 mM solution in DMSO. A cell-permeable, potent analog of Cyclopamine. Inhibits Hedgehog signaling (IC50 = 20 nM) with lower toxicity.

InSolution™ Cyclopamine-KAAD - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: 3-Keto-N-(aminoethyl-aminocaproyl-dihydrocinnamoyl)cyclopamine

Primary Target: SmoA1

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概述

Replacement Information

重要规格表

Empirical Formula
C₄₄H₆₃Nl₃O₄

价格及供货情况

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Description
Overview	A cell-permeable potent analog of Cyclopamine (Cat. No. 239803) that specifically inhibits Hedgehog (Hh) signaling with similar or lower toxicity (IC₅₀ = 20 nM in Shh-LIGHT2 assay; 50 nM in p2^Ptch-/-cells; 500 nM in SmoA1-LIGHT cells). Binds to SmoA1 and promotes its exit from the endoplasmic reticulum. Suppresses both ShhNp-induced pathway activity and SmoA1-induced reporter activity. Reported to cause regression of murine tumor allografts in vivo and induce rapid cell death in human medulloblastoma. Shown to sensitize human glioma cells to TRAIL-induced apoptosis. The solid form of this compound (Cat. No. 239804) is also available.
Catalogue Number	239807
Brand Family	Calbiochem®
Synonyms	3-Keto-N-(aminoethyl-aminocaproyl-dihydrocinnamoyl)cyclopamine

References
References	Siegelin, M.D. et al. 2009. Neurobiol. Dis. 34, 259. Watkins, D.N., et al. 2003. Nature 422, 313. Berman, D.M., et al. 2002. Science 297, 1559. Chen, J.K., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 14071. Chen, J.K., et al. 2002. Genes Dev. 16, 2743. Frank-Kamenetsky, M., et al. 2002. J. Biol. 1, 10. Taipale, J., et al. 2000. Nature 406, 1005.

Product Information
Form	Liquid
Formulation	A 1 mM (50 µg/72 µL) solution of Cyclopamine-KAAD (Cat. No. 239804) in DMSO.
Hill Formula	C₄₄H₆₃Nl₃O₄
Hygroscopic	Hygroscopic
Structure formula Image
Quality Level	MQ100

Applications
Application	InSolution™ Cyclopamine-KAAD, CAS 306387-90-6, is a 1 mM solution in DMSO. A cell-permeable, potent analog of Cyclopamine. Inhibits Hedgehog signaling (IC50 = 20 nM) with lower toxicity.

Biological Information
Primary Target	SmoA1
Purity	≥70% by HPLC (sum of two isomers)

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information
R Phrase	R: 36/38 Irritating to eyes and skin.
S Phrase	S: 26-36/37/39 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing, gloves and eye/face protection.

Product Usage Statements

Storage and Shipping Information
Ship Code	Dry Ice Only
Toxicity	Irritant
Storage	≤ -70°C
Protect from Light	Protect from light
Hygroscopic	Hygroscopic
Avoid freeze/thaw	Avoid freeze/thaw
Do not freeze	Ok to freeze
Special Instructions	Following initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 6 months at -70°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
239807-50UGCN	04055977198928

Documentation

InSolution™ Cyclopamine-KAAD - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

InSolution™ Cyclopamine-KAAD - Calbiochem 分析证书

标题	批号
239807	输入批号

参考

参考信息概述
Siegelin, M.D. et al. 2009. Neurobiol. Dis. 34, 259. Watkins, D.N., et al. 2003. Nature 422, 313. Berman, D.M., et al. 2002. Science 297, 1559. Chen, J.K., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 14071. Chen, J.K., et al. 2002. Genes Dev. 16, 2743. Frank-Kamenetsky, M., et al. 2002. J. Biol. 1, 10. Taipale, J., et al. 2000. Nature 406, 1005.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	21-September-2012 JSW
Synonyms	3-Keto-N-(aminoethyl-aminocaproyl-dihydrocinnamoyl)cyclopamine
Description	A cell-permeable potent analog of Cyclopamine (Cat. No. 239803) that specifically inhibits Hedgehog (Hh) signaling with similar or lower toxicity (IC₅₀ = 20 nM in Shh-LIGHT2 assay; 50 nM in p2^Ptch-/-cells; 500 nM in SmoA1-LIGHT cells). Binds to SmoA1 and promotes its exit from the endoplasmic reticulum. Suppresses both ShhNp-induced pathway activity and SmoA1-induced reporter activity. Reported to cause regression of murine tumor allografts in vivo and induce rapid cell death in human medulloblastoma. Shown to sensitize human glioma cells to TRAIL-induced apoptosis. The solid form of this compound (Cat. No. 239804) is also available.
Form	Liquid
Formulation	A 1 mM (50 µg/72 µL) solution of Cyclopamine-KAAD (Cat. No. 239804) in DMSO.
Intert gas (Yes/No)	Packaged under inert gas
Structure formula
Purity	≥70% by HPLC (sum of two isomers)
Storage	Protect from light Avoid freeze/thaw ≤ -70°C Hygroscopic
Do Not Freeze	Ok to freeze
Special Instructions	Following initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 6 months at -70°C.
Toxicity	Irritant
References	Siegelin, M.D. et al. 2009. Neurobiol. Dis. 34, 259. Watkins, D.N., et al. 2003. Nature 422, 313. Berman, D.M., et al. 2002. Science 297, 1559. Chen, J.K., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 14071. Chen, J.K., et al. 2002. Genes Dev. 16, 2743. Frank-Kamenetsky, M., et al. 2002. J. Biol. 1, 10. Taipale, J., et al. 2000. Nature 406, 1005.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Stem Cell Biology > Sonic Hedgehog Signaling Inhibitors

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