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235427 Sigma-AldrichInSolution™ Caspase-3 Inhibitor I, Cell-Permeable - Calbiochem

The InSolution™ Caspase-3 Inhibitor I, Cell-Permeable controls the biological activity of Caspase-3. This small molecule/inhibitor is primarily used for Cancer applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
小册子
Data Sheet
Citations

同义词: Cell-permeable, DEVD-CHO; CPP32/Apopain Inhibitor, Cell-permeable

Primary Target: caspase-3

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概述

Replacement Information

重要规格表

Empirical Formula
C₉₄H₁₅₈N₂₀O₂₇

价格及供货情况

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Description
Catalogue Number	235427
Brand Family	Calbiochem®
Synonyms	Cell-permeable, DEVD-CHO; CPP32/Apopain Inhibitor, Cell-permeable

References
References	Lin, Y.-Z., et al. 1996. J. Biol. Chem. 271, 5305. Nicholson, D.W. 1996. Nature Biotechnol. 14, 297. Schlegel, J., et al. 1996. J. Biol. Chem. 271, 1841. Lin, Y.-Z., et al. 1995. J. Biol. Chem. 270, 14255. Nicholson, D.W., et al. 1995. Nature 376, 37. Tewari, M., et al. 1995. Cell 81, 801. Lazebnik, Y.A., et al. 1994. Nature 371, 346.

Product Information
ATP Competitive	N
Form	Liquid
Formulation	A 5 mM (1 mg/100 µl) solution of Caspase-3 Inhibitor I, Cell-permeable (Cat. No. 235423) in DMSO.
Hill Formula	C₉₄H₁₅₈N₂₀O₂₇
Chemical formula	C₉₄H₁₅₈N₂₀O₂₇
Hygroscopic	Hygroscopic
Reversible	Y
Quality Level	MQ100

Applications

Biological Information
Primary Target	caspase-3
Primary Target IC<sub>50</sub>	200 pM inhibiting PARP cleavage in cultured human osteosarcoma cell extracts
Purity	≥90% by HPLC

Physicochemical Information
Cell permeable	Y
Peptide Sequence	Ac-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Asp-Glu-Val-Asp-CHO

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information
R Phrase	R: 36/38 Irritating to eyes and skin.
S Phrase	S: 26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.

Product Usage Statements

Storage and Shipping Information
Ship Code	Blue Ice Only
Toxicity	Irritant
Storage	-20°C
Protect from Light	Protect from light
Hygroscopic	Hygroscopic
Do not freeze	Ok to freeze
Special Instructions	Following initial thaw, aliquot, purge with inert gas, and freeze (-20°C).

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
235427-1MGCN	04055977217056

Documentation

InSolution™ Caspase-3 Inhibitor I, Cell-Permeable - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

InSolution™ Caspase-3 Inhibitor I, Cell-Permeable - Calbiochem 分析证书

标题	批号
235427	输入批号

参考

参考信息概述
Lin, Y.-Z., et al. 1996. J. Biol. Chem. 271, 5305. Nicholson, D.W. 1996. Nature Biotechnol. 14, 297. Schlegel, J., et al. 1996. J. Biol. Chem. 271, 1841. Lin, Y.-Z., et al. 1995. J. Biol. Chem. 270, 14255. Nicholson, D.W., et al. 1995. Nature 376, 37. Tewari, M., et al. 1995. Cell 81, 801. Lazebnik, Y.A., et al. 1994. Nature 371, 346.

小册子

标题
Caspases and other Apoptosis Related Tools Brochure

引用

标题

Jurg Grunenfelder, et al. (2001) Upregulation of Bcl-2 through caspase-3 inhibition ameliorates ischemia/reperfusion injury in rat cardiac allografts. Circulation 104, I202-I206.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	18-March-2008 JSW
Synonyms	Cell-permeable, DEVD-CHO; CPP32/Apopain Inhibitor, Cell-permeable
Description	A cell-permeable inhibitor of caspase-3. The C-terminal DEVD-CHO sequence of this peptide is a highly specific, potent, and reversible inhibitor of caspase-3 (K_i <1 nM) that has also been shown to strongly inhibit PARP cleavage in cultured human osteosarcoma cell extracts (IC₅₀ = 200 pM). The N-terminal sequence (residues 1-16) corresponds to the hydrophobic region (h-region) of the signal peptide of Kaposi fibroblast growth factor (K-FGF) and confers cell-permeability to the peptide.
Form	Liquid
Formulation	A 5 mM (1 mg/100 µl) solution of Caspase-3 Inhibitor I, Cell-permeable (Cat. No. 235423) in DMSO.
Intert gas (Yes/No)	Packaged under inert gas
Chemical formula	C₉₄H₁₅₈N₂₀O₂₇
Peptide Sequence	Ac-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Asp-Glu-Val-Asp-CHO
Purity	≥90% by HPLC
Storage	Protect from light -20°C Hygroscopic
Do Not Freeze	Ok to freeze
Special Instructions	Following initial thaw, aliquot, purge with inert gas, and freeze (-20°C).
Toxicity	Irritant
References	Lin, Y.-Z., et al. 1996. J. Biol. Chem. 271, 5305. Nicholson, D.W. 1996. Nature Biotechnol. 14, 297. Schlegel, J., et al. 1996. J. Biol. Chem. 271, 1841. Lin, Y.-Z., et al. 1995. J. Biol. Chem. 270, 14255. Nicholson, D.W., et al. 1995. Nature 376, 37. Tewari, M., et al. 1995. Cell 81, 801. Lazebnik, Y.A., et al. 1994. Nature 371, 346.
Citation	Jurg Grunenfelder, et al. (2001) Upregulation of Bcl-2 through caspase-3 inhibition ameliorates ischemia/reperfusion injury in rat cardiac allografts. Circulation 104, I202-I206.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Apoptosis/Necrosis Inhibitors > Caspase Inhibitors

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