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218861 Sigma-AldrichInSolution™ Casein Kinase II Inhibitor III, TBCA - CAS 934358-00-6 - Calbiochem

The InSolution™ Casein Kinase II Inhibitor III, TBCA, also referenced under CAS 934358-00-6, controls the biological activity of Casein Kinase II. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: (E)-3-(2,3,4,5-Tetrabromophenyl)acrylic acid

Primary Target: CKII

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概述

Replacement Information

重要规格表

CAS #	Empirical Formula
934358-00-6	C₉H₄Br₄O₂

价格及供货情况

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Description
Overview	A cell-permeable tetrabrominated cinnamic acid compound that acts as a potent and ATP-competitive inhibitor of Casein Kinase II (IC₅₀ = 110 nM, K_i = 77 nM) with greater selectivity than TBB (Cat. No. 218697 and Cat. No. 218708) and DMAT (Cat. No. 218699 and Cat. No. 218706) against a panel of 28 commonly studied kinases. Shown to efficiently induce apoptosis in Jurkat cells (DC₅₀ = 7.7 µM). The solid form of this compound (Cat. No. 218710) is also available.
Catalogue Number	218861
Brand Family	Calbiochem®
Synonyms	(E)-3-(2,3,4,5-Tetrabromophenyl)acrylic acid

References
References	Pagano, M.A., et al. 2006. Chembiochem,/i> 8, 129.

Product Information
CAS number	934358-00-6
Form	Liquid
Formulation	A 25 mM (5 mg/431 µL) solution of Casein Kinase II Inhibitor III, TBCA (Cat. No. 218710) in DMSO.
Hill Formula	C₉H₄Br₄O₂
Hygroscopic	Hygroscopic
Reversible	Y
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	CKII
Purity	≥90% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information
R Phrase	R: 36/38 Irritating to eyes and skin.
S Phrase	S: 26-36 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing.

Product Usage Statements

Storage and Shipping Information
Ship Code	Dry Ice Only
Toxicity	Irritant
Storage	≤ -70°C
Protect from Light	Protect from light
Hygroscopic	Hygroscopic
Avoid freeze/thaw	Avoid freeze/thaw
Do not freeze	Ok to freeze
Special Instructions	Following initial thaw, aliquot and freeze (-20°C). Aliquots are stable for up to 6 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
218861-5MGCN	04055977201970

Documentation

InSolution™ Casein Kinase II Inhibitor III, TBCA - CAS 934358-00-6 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

InSolution™ Casein Kinase II Inhibitor III, TBCA - CAS 934358-00-6 - Calbiochem 分析证书

标题	批号
218861	输入批号

参考

参考信息概述
Pagano, M.A., et al. 2006. Chembiochem,/i> 8, 129.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	21-September-2012 JSW
Synonyms	(E)-3-(2,3,4,5-Tetrabromophenyl)acrylic acid
Description	A cell-permeable tetrabrominated cinnamic acid compound that acts as a potent and ATP-competitive inhibitor of Casein Kinase II (IC₅₀ = 110 nM, K_i = 77 nM) with greater selectivity than TBB (Cat. No. 218697 and Cat. No. 218708) and DMAT (Cat. No. 218699 and Cat. No. 218706) against a panel of 28 commonly studied kinases. Shown to efficiently induce apoptosis in Jurkat cells (DC₅₀ = 7.7 µM). The solid form of this compound (Cat. No. 218710) is also available.
Form	Liquid
Formulation	A 25 mM (5 mg/431 µL) solution of Casein Kinase II Inhibitor III, TBCA (Cat. No. 218710) in DMSO.
Intert gas (Yes/No)	Packaged under inert gas
CAS number	934358-00-6
Structure formula
Purity	≥90% by HPLC
Storage	Protect from light Avoid freeze/thaw ≤ -70°C Hygroscopic
Do Not Freeze	Ok to freeze
Special Instructions	Following initial thaw, aliquot and freeze (-20°C). Aliquots are stable for up to 6 months at -20°C.
Toxicity	Irritant
References	Pagano, M.A., et al. 2006. Chembiochem,/i> 8, 129.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Casein Kinase (CK) Inhibitors

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