数量	产品目录编号	订购说明	数量 / 包装	公开价
			96-Well Plate

数量	产品目录编号	订购说明	数量 / 包装	公开价
	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

508226 Sigma-AldrichInSolution™ Calyculin A, Discodermia calyx - CAS 101932-71-2 - Calbiochem

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
参考
Data Sheet

Primary Target: protein phosphatase-2A & -1

Recommended Products

概述

Replacement Information

重要规格表

CAS #	Empirical Formula
101932-71-2	C₅₀H₈₁N₄O₁₅P

价格及供货情况

产品目录编号	库存情况	包装	数量 / 包装	价格	数量
5.08226.0001	正在查询供货情况...... — 目前缺货有货停产少量现货供货情况有待确认登录查看库存有货目前缺货有货其余：另行通知其余：另行通知另行通知联系客户服务 Contact Customer Service 联系客户服务联系客户服务	玻璃瓶	5 μg	正在检索价格...... 无法检索价格。最小订购数量为倍数 Maximum Quantity is 以订单确认为准更多信息您节约了 ()。 — Request Pricing 登录查看价格	查看库存情况 —	添加到收藏夹添加到收藏夹添加到我的收藏夹

Description
Catalogue Number	508226
Brand Family	Calbiochem®

References
References	Murakami, N., et al. 1994. Neurosci. Lett. 176, 181. Takeuchi, T., et al. 1994. Biochem. Biophys. Res. Commun. 205, 1803. Figurov, A., et al. 1993. Eur. J. Neurosci. 5, 1083. Song, Q., and Lavin, M.F. 1993. Biochem. Biophys. Res. Commun. 190, 47. Gopalakrishna, R., et al. 1992. Biochem. Biophys. Res. Commun. 189, 950. Carl, A., et al. 1991. Am. J. Physiol. 261, C387. Suganuma, M., et al. 1990. Cancer Res. 50, 3521. Cohen, P. 1989. Annu. Rev. Biochem. 58, 453. Cohen, P., et al. 1989. J. Biol. Chem. 264, 21435. Ishihara, H., et al. 1989. Biochem. Biophys. Res. Commun. 159, 871. Kato, Y., et al. 1988. J. Org. Chem. 53, 3930. Kato, Y., et al. 1986. J. Am. Chem. Soc. 108, 2780.

References

Murakami, N., et al. 1994. Neurosci. Lett. 176, 181.
Takeuchi, T., et al. 1994. Biochem. Biophys. Res. Commun. 205, 1803.
Figurov, A., et al. 1993. Eur. J. Neurosci. 5, 1083.
Song, Q., and Lavin, M.F. 1993. Biochem. Biophys. Res. Commun. 190, 47.
Gopalakrishna, R., et al. 1992. Biochem. Biophys. Res. Commun. 189, 950.
Carl, A., et al. 1991. Am. J. Physiol. 261, C387.
Suganuma, M., et al. 1990. Cancer Res. 50, 3521.
Cohen, P. 1989. Annu. Rev. Biochem. 58, 453.
Cohen, P., et al. 1989. J. Biol. Chem. 264, 21435.
Ishihara, H., et al. 1989. Biochem. Biophys. Res. Commun. 159, 871.
Kato, Y., et al. 1988. J. Org. Chem. 53, 3930.
Kato, Y., et al. 1986. J. Am. Chem. Soc. 108, 2780.

Product Information
CAS number	101932-71-2
Form	Liquid
Formulation	A 100 µM (5 µg/50 µL) sterile-filtered solution of Calyculin A, Discodermia calyx (Cat. No. 208851) in DMSO.
Hill Formula	C₅₀H₈₁N₄O₁₅P
Chemical formula	C₅₀H₈₁N₄O₁₅P
Hygroscopic	Hygroscopic
Reversible	Y
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	protein phosphatase-2A & -1
Primary Target IC<sub>50</sub>	0.5-1.0 and 2 nM for PP2A and PP1, respectively
Purity	≥98% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Dry Ice Only
Toxicity	Standard Handling
Storage	≤ -70°C
Protect from Light	Protect from light
Hygroscopic	Hygroscopic
Avoid freeze/thaw	Avoid freeze/thaw
Do not freeze	Ok to freeze
Special Instructions	Following initial thaw, aliquot and freeze (-20°C). Aliquots are stable for up to 6 months at -20°C. Use only fresh DMSO for further dilutions.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
5.08226.0001	04055977261776

Documentation

InSolution™ Calyculin A, Discodermia calyx - CAS 101932-71-2 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

参考

参考信息概述
Murakami, N., et al. 1994. Neurosci. Lett. 176, 181. Takeuchi, T., et al. 1994. Biochem. Biophys. Res. Commun. 205, 1803. Figurov, A., et al. 1993. Eur. J. Neurosci. 5, 1083. Song, Q., and Lavin, M.F. 1993. Biochem. Biophys. Res. Commun. 190, 47. Gopalakrishna, R., et al. 1992. Biochem. Biophys. Res. Commun. 189, 950. Carl, A., et al. 1991. Am. J. Physiol. 261, C387. Suganuma, M., et al. 1990. Cancer Res. 50, 3521. Cohen, P. 1989. Annu. Rev. Biochem. 58, 453. Cohen, P., et al. 1989. J. Biol. Chem. 264, 21435. Ishihara, H., et al. 1989. Biochem. Biophys. Res. Commun. 159, 871. Kato, Y., et al. 1988. J. Org. Chem. 53, 3930. Kato, Y., et al. 1986. J. Am. Chem. Soc. 108, 2780.

参考信息概述

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	13-December-2013 JSW
Description	Cell-permeable protein phosphatase 2A (PP2A) inhibitor (IC₅₀ = 0.5-1.0 nM). Also inhibits protein phosphatase 1 (PP1; IC₅₀ = 2 nM). A non-phorbol ester type tumor promoter that induces oxidative DNA damage. Selectively increases the efficacy of AMPA receptor-mediated synaptic transmission at excitatory synapses. Recently, it has been used to study the regulation of Ca²⁺-activated K⁺ channels in smooth muscle and to correlate shape changes in fibroblasts with the degree of protein phosphorylation. Also known to prevent γ-radiation induced apoptosis in Burkitt's lymphoma cell line BM13674.
Form	Liquid
Formulation	A 100 µM (5 µg/50 µL) sterile-filtered solution of Calyculin A, Discodermia calyx (Cat. No. 208851) in DMSO.
Intert gas (Yes/No)	Packaged under inert gas
CAS number	101932-71-2
Chemical formula	C₅₀H₈₁N₄O₁₅P
Structure formula
Purity	≥98% by HPLC
Storage	Protect from light Avoid freeze/thaw ≤ -70°C Hygroscopic
Do Not Freeze	Ok to freeze
Special Instructions	Following initial thaw, aliquot and freeze (-20°C). Aliquots are stable for up to 6 months at -20°C. Use only fresh DMSO for further dilutions.
Toxicity	Standard Handling
References	Murakami, N., et al. 1994. Neurosci. Lett. 176, 181. Takeuchi, T., et al. 1994. Biochem. Biophys. Res. Commun. 205, 1803. Figurov, A., et al. 1993. Eur. J. Neurosci. 5, 1083. Song, Q., and Lavin, M.F. 1993. Biochem. Biophys. Res. Commun. 190, 47. Gopalakrishna, R., et al. 1992. Biochem. Biophys. Res. Commun. 189, 950. Carl, A., et al. 1991. Am. J. Physiol. 261, C387. Suganuma, M., et al. 1990. Cancer Res. 50, 3521. Cohen, P. 1989. Annu. Rev. Biochem. 58, 453. Cohen, P., et al. 1989. J. Biol. Chem. 264, 21435. Ishihara, H., et al. 1989. Biochem. Biophys. Res. Commun. 159, 871. Kato, Y., et al. 1988. J. Org. Chem. 53, 3930. Kato, Y., et al. 1986. J. Am. Chem. Soc. 108, 2780.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Protein Phosphatase Inhibitors

此产品已添加到您的购物车。