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219675 Sigma-AldrichInSolution™ CFTR Inhibitor II, GlyH-101 - CAS 328541-79-3 - Calbiochem

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: N-(2-Naphthalenyl)-((3,5-dibromo-2,4-dihydroxyphenyl)methylene)glycine hydrazide

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概述

Replacement Information

价格及供货情况

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Description
Overview	A cell-permeable glycinyl hydrazone compound that acts as a potent, selective and reversible open-channel blocker of CFTR with intermediate speed (<1 min; 95% inhibition at 50 µM; K_i = 4.3 µM in CFTR-expressing FRT cells for apical membrane Cl^- current) and exhibits desirable aqueous solubility. Shown to produce inwardly rectifying CFTR Cl^- currents with reduced mean channel open time and suggested to directly interact with the channel pore at the extracellular side of the membrane. Displays minimal effects on P-glycoprotein and non-CFTR-mediated Cl^- currents, and is effective in nasal and intestinal epithelia in vivo.
Catalogue Number	219675
Brand Family	Calbiochem®
Synonyms	N-(2-Naphthalenyl)-((3,5-dibromo-2,4-dihydroxyphenyl)methylene)glycine hydrazide

References
References	Sonawane, N.D., et al. 2006. FASEB J. 20, 130. Muanprasat, C., et al. 2004. J. Gen. Physiol. 124, 125.

Product Information
CAS number	328541-79-3
Form	Liquid
Formulation	A 25 mM (5 mg/406 µL) solution of CFTR Inhibitor II, GlyH-101 (Cat. No. 219671) in DMSO.
Hill Formula	C₁₉H₁₅Br₂N₃O₃
Chemical formula	C₁₉H₁₅Br₂N₃O₃
Hygroscopic	Hygroscopic
Reversible	Y
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	CFTR
Primary Target K<sub>i</sub>	4.3 µ
Purity	≥97% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information
R Phrase	R: 36/38 Irritating to eyes and skin.
S Phrase	S: 26-36 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing.

Product Usage Statements

Storage and Shipping Information
Ship Code	Dry Ice Only
Toxicity	Irritant
Storage	≤ -70°C
Protect from Light	Protect from light
Hygroscopic	Hygroscopic
Avoid freeze/thaw	Avoid freeze/thaw
Do not freeze	Ok to freeze
Special Instructions	Following initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 3 months at -70°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
219675-5MGCN	04055977200935

Documentation

InSolution™ CFTR Inhibitor II, GlyH-101 - CAS 328541-79-3 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

InSolution™ CFTR Inhibitor II, GlyH-101 - CAS 328541-79-3 - Calbiochem 分析证书

标题	批号
219675	输入批号

参考

参考信息概述
Sonawane, N.D., et al. 2006. FASEB J. 20, 130. Muanprasat, C., et al. 2004. J. Gen. Physiol. 124, 125.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	01-March-2013 JSW
Synonyms	N-(2-Naphthalenyl)-((3,5-dibromo-2,4-dihydroxyphenyl)methylene)glycine hydrazide
Description	A cell-permeable glycinyl hydrazone compound that acts as a potent, selective and reversible open-channel blocker of CFTR with intermediate speed (<1 min; 95% inhibition at 50 µM; K_i = 4.3 µM in CFTR-expressing FRT cells for apical membrane Cl^- current) and exhibits desirable aqueous solubility. Shown to produce inwardly rectifying CFTR Cl^- currents with reduced mean channel open time and suggested to directly interact with the channel pore at the extracellular side of the membrane. Displays minimal effects on P-glycoprotein and non-CFTR-mediated Cl^- currents, and is effective in nasal and intestinal epithelia in vivo.
Form	Liquid
Formulation	A 25 mM (5 mg/406 µL) solution of CFTR Inhibitor II, GlyH-101 (Cat. No. 219671) in DMSO.
Intert gas (Yes/No)	Packaged under inert gas
CAS number	328541-79-3
Chemical formula	C₁₉H₁₅Br₂N₃O₃
Structure formula
Purity	≥97% by HPLC
Storage	Protect from light Avoid freeze/thaw ≤ -70°C Hygroscopic
Do Not Freeze	Ok to freeze
Special Instructions	Following initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 3 months at -70°C.
Toxicity	Irritant
References	Sonawane, N.D., et al. 2006. FASEB J. 20, 130. Muanprasat, C., et al. 2004. J. Gen. Physiol. 124, 125.

种类

Life Science Research > Inhibitors and Biochemicals

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