数量	产品目录编号	订购说明	数量 / 包装	公开价
			96-Well Plate

数量	产品目录编号	订购说明	数量 / 包装	公开价
	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

197334 Sigma-AldrichInSolution™ Bcl-2 Inhibitor VI, ABT-737 - Calbiochem

A 25 mM (5 mg/246 µL) solution of Bcl-2 Inhibitor VI, ABT-737 in DMSO

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

分析证书
参考
Data Sheet

同义词: (R)-4-(4-((4ʹ-Chlorobiphenyl-2-yl)methyl)piperazin-1-yl)-N-(4-(4-(dimethylamino)-1-(phenylthio)butan-2-ylamino)-3-nitrophenylsulfonyl)benzamide, 4-(4-((4ʹ-Chlorobiphenyl-2-yl)methyl)piperazin-1-yl)-N-((4-(((1R)-3-(dimethylamino)-1-((phenylsulfanyl)methyl)propyl)amino)-3-nitrophenyl)sulfonyl)benzamide

Recommended Products

概述

Replacement Information

重要规格表

Empirical Formula
C₄₂H₄₅ClN₆O₅S₂

价格及供货情况

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Description
Catalogue Number	197334
Brand Family	Calbiochem®
Synonyms	(R)-4-(4-((4ʹ-Chlorobiphenyl-2-yl)methyl)piperazin-1-yl)-N-(4-(4-(dimethylamino)-1-(phenylthio)butan-2-ylamino)-3-nitrophenylsulfonyl)benzamide, 4-(4-((4ʹ-Chlorobiphenyl-2-yl)methyl)piperazin-1-yl)-N-((4-(((1R)-3-(dimethylamino)-1-((phenylsulfanyl)methyl)propyl)amino)-3-nitrophenyl)sulfonyl)benzamide

References
References	Bardwell, P.D., et al. 2009. J. Immunol. 182, 7482. Oltersdorf, T., et al. 2005. Nature 435, 677.

Product Information
Form	Liquid
Formulation	A 25 mM (5 mg/246 µL) solution of Bcl-2 Inhibitor VI, ABT-737 (Cat. No. 197333) in DMSO.
Hill Formula	C₄₂H₄₅ClN₆O₅S₂
Chemical formula	C₄₂H₄₅ClN₆O₅S₂
Hygroscopic	Hygroscopic
Reversible	Y
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	Bcl-2 family members
Purity	≥97% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Dry Ice Only
Toxicity	Standard Handling
Storage	≤ -70°C
Protect from Light	Protect from light
Hygroscopic	Hygroscopic
Avoid freeze/thaw	Avoid freeze/thaw
Do not freeze	Ok to freeze
Special Instructions	Following initial thaw, aliquot and freeze (-20°C). Aliquots are stable for up to 3 months at -20°C. For longer term storage of aliquots, store at -70°C. Use only fresh DMSO for further serial dilutions.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
197334-5MGCN	04055977206111

Documentation

InSolution™ Bcl-2 Inhibitor VI, ABT-737 - Calbiochem 分析证书

标题	批号
197334	输入批号

参考

参考信息概述
Bardwell, P.D., et al. 2009. J. Immunol. 182, 7482. Oltersdorf, T., et al. 2005. Nature 435, 677.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	28-March-2014 JSW
Synonyms	(R)-4-(4-((4ʹ-Chlorobiphenyl-2-yl)methyl)piperazin-1-yl)-N-(4-(4-(dimethylamino)-1-(phenylthio)butan-2-ylamino)-3-nitrophenylsulfonyl)benzamide, 4-(4-((4ʹ-Chlorobiphenyl-2-yl)methyl)piperazin-1-yl)-N-((4-(((1R)-3-(dimethylamino)-1-((phenylsulfanyl)methyl)propyl)amino)-3-nitrophenyl)sulfonyl)benzamide
Description	A cell-permeable nitrophenylsulfonylbenzamide compound that is shown to bind anti-apoptotic Bcl-2 family members Bcl-2, Bcl-XL, and Bcl-w with high affinity (K_i ≤1 nM) and serves as a nonpeptidyl alternative to Bad-derived BH3 peptide (Cat. No. 197220) in preventing the binding and inhibition of the pro- apoptotic by the anti-apoptotic Bcl-2 family proteins. ABT-737 is demonstrated to fully reverse the blockage of Myr-Bid-induced cytochrome c release by Bcl-2 in mitochondria preparations from Bcl-2 overexpressing FL5.12 cells and effectively inhibit the growth of numerous cancer cells both in cultures in vitro (IC₅₀ ≤100 nM against H146 and H1963) and in vivo (complete regression of H146 and H1963 in xenograft mice at 100 mg/kg/day, i.p.). Application of ABT-737 is also demonstrated to significantly reduce the disease severity in several murine models of autoimmunity.
Form	Liquid
Formulation	A 25 mM (5 mg/246 µL) solution of Bcl-2 Inhibitor VI, ABT-737 (Cat. No. 197333) in DMSO.
Intert gas (Yes/No)	Packaged under inert gas
Chemical formula	C₄₂H₄₅ClN₆O₅S₂
Structure formula
Purity	≥97% by HPLC
Storage	Protect from light Avoid freeze/thaw ≤ -70°C Hygroscopic
Do Not Freeze	Ok to freeze
Special Instructions	Following initial thaw, aliquot and freeze (-20°C). Aliquots are stable for up to 3 months at -20°C. For longer term storage of aliquots, store at -70°C. Use only fresh DMSO for further serial dilutions.
Toxicity	Standard Handling
References	Bardwell, P.D., et al. 2009. J. Immunol. 182, 7482. Oltersdorf, T., et al. 2005. Nature 435, 677.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Inducers > Apoptosis Inducers

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