数量	产品目录编号	订购说明	数量 / 包装	公开价
			96-Well Plate

数量	产品目录编号	订购说明	数量 / 包装	公开价
	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

508408 Sigma-AldrichInSolution™ Batimastat - CAS 130370-60-4 - Calbiochem

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
参考
Data Sheet

同义词: (4-N-Hydroxyamino)-2R-isobutyl-3S-(thienylthiomethyl)succinyl)-L-phenylalanine-N-methylamide

Primary Target: MMPs

Recommended Products

概述

Replacement Information

重要规格表

CAS #	Empirical Formula
130370-60-4	C₂₃H₃₁N₃O₄S₂

价格及供货情况

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Description
Catalogue Number	508408
Brand Family	Calbiochem®
Synonyms	(4-N-Hydroxyamino)-2R-isobutyl-3S-(thienylthiomethyl)succinyl)-L-phenylalanine-N-methylamide

References
References	Schlomann, U., et al. 2002. J. Biol. Chem. 277, 48210. Whittaker, M., et al. 1999. Chem. Rev. 99, 2735. Parvathy, S., et al. 1998. Biochemistry 37, 1680. Parvathy, S., et al. 1998. FEBS Lett. 431, 63. Yamamoto, M., et al. 1998. J. Med. Chem. 41, 1209. Moss, M.L., et al. 1997. Nature 385, 733. Eccles, S.A., et al. 1996. Cancer Res. 56, 2815. Brown, P.D. 1995. Advan. Enzyme Regul. 35, 293. Wang, X., et al. 1994. Cancer Res. 54, 4726. Davies, B., et al. 1993. Cancer Res. 53, 2087.

References

Schlomann, U., et al. 2002. J. Biol. Chem. 277, 48210.
Whittaker, M., et al. 1999. Chem. Rev. 99, 2735.
Parvathy, S., et al. 1998. Biochemistry 37, 1680.
Parvathy, S., et al. 1998. FEBS Lett. 431, 63.
Yamamoto, M., et al. 1998. J. Med. Chem. 41, 1209.
Moss, M.L., et al. 1997. Nature 385, 733.
Eccles, S.A., et al. 1996. Cancer Res. 56, 2815.
Brown, P.D. 1995. Advan. Enzyme Regul. 35, 293.
Wang, X., et al. 1994. Cancer Res. 54, 4726.
Davies, B., et al. 1993. Cancer Res. 53, 2087.

Product Information
CAS number	130370-60-4
Form	Liquid
Formulation	A 25 mM (2 mg/168 µL) sterile-filtered solution of Batimastat (Cat. No. 196440) in DMSO.
Hill Formula	C₂₃H₃₁N₃O₄S₂
Chemical formula	C₂₃H₃₁N₃O₄S₂
Hygroscopic	Hygroscopic
Reversible	Y
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	MMPs
Purity	≥97% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Dry Ice Only
Toxicity	Standard Handling
Storage	≤ -70°C
Protect from Light	Protect from light
Hygroscopic	Hygroscopic
Avoid freeze/thaw	Avoid freeze/thaw
Do not freeze	Ok to freeze
Special Instructions	Following initial thaw, aliquot and freeze (-20°C). Aliquots are stable for up to 6 months at -20°C. Use only fresh DMSO for further dilutions.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
5.08408.0001	04055977261929

Documentation

InSolution™ Batimastat - CAS 130370-60-4 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

参考

参考信息概述
Schlomann, U., et al. 2002. J. Biol. Chem. 277, 48210. Whittaker, M., et al. 1999. Chem. Rev. 99, 2735. Parvathy, S., et al. 1998. Biochemistry 37, 1680. Parvathy, S., et al. 1998. FEBS Lett. 431, 63. Yamamoto, M., et al. 1998. J. Med. Chem. 41, 1209. Moss, M.L., et al. 1997. Nature 385, 733. Eccles, S.A., et al. 1996. Cancer Res. 56, 2815. Brown, P.D. 1995. Advan. Enzyme Regul. 35, 293. Wang, X., et al. 1994. Cancer Res. 54, 4726. Davies, B., et al. 1993. Cancer Res. 53, 2087.

参考信息概述

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	13-December-2013 JSW
Synonyms	(4-N-Hydroxyamino)-2R-isobutyl-3S-(thienylthiomethyl)succinyl)-L-phenylalanine-N-methylamide
Description	A Marimastat (Cat. No. 444289) type of peptidyl hydroxamate-based inhibitor that potently inhibits a broad-spectrum of metalloproteinases, including MMP-1, MMP-2, MMP-3/stromelysin, MMP-7/matrilysin, MMP-9, ΔMT1 (MMP-14 without TM domain), ADAM8, and ADAM17/TACE (IC₅₀ = 3, 4, 20, 6, 4, 2.08, 51.3, and 19 nM, respectively), by targeting both the substrate binding site and the active-site Zn²⁺, while being much less potent toward ACE (Angiotensin Converting Enzyme) or α-secretase (IC₅₀ = 1.6 and 3.3 µM, respectively). Batimastat is widely used in studying the involvement of MMPs in cancinogenesis and non-cancer pathological processes both in cultures in vitro and in animals in vivo.
Form	Liquid
Formulation	A 25 mM (2 mg/168 µL) sterile-filtered solution of Batimastat (Cat. No. 196440) in DMSO.
Intert gas (Yes/No)	Packaged under inert gas
CAS number	130370-60-4
Chemical formula	C₂₃H₃₁N₃O₄S₂
Structure formula
Purity	≥97% by HPLC
Storage	Protect from light Avoid freeze/thaw ≤ -70°C Hygroscopic
Do Not Freeze	Ok to freeze
Special Instructions	Following initial thaw, aliquot and freeze (-20°C). Aliquots are stable for up to 6 months at -20°C. Use only fresh DMSO for further dilutions.
Toxicity	Standard Handling
References	Schlomann, U., et al. 2002. J. Biol. Chem. 277, 48210. Whittaker, M., et al. 1999. Chem. Rev. 99, 2735. Parvathy, S., et al. 1998. Biochemistry 37, 1680. Parvathy, S., et al. 1998. FEBS Lett. 431, 63. Yamamoto, M., et al. 1998. J. Med. Chem. 41, 1209. Moss, M.L., et al. 1997. Nature 385, 733. Eccles, S.A., et al. 1996. Cancer Res. 56, 2815. Brown, P.D. 1995. Advan. Enzyme Regul. 35, 293. Wang, X., et al. 1994. Cancer Res. 54, 4726. Davies, B., et al. 1993. Cancer Res. 53, 2087.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Proteases Inhibitors > Matrix Metalloproteinase (MMP) Inhibitors

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