数量	产品目录编号	订购说明	数量 / 包装	公开价
			96-Well Plate

数量	产品目录编号	订购说明	数量 / 包装	公开价
	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

508409 Sigma-AldrichInSolution™ Bafilomycin A1, ≥97% by HPLC - CAS 88899-55-2 - Calbiochem

This product can no longer be ordered through emdmillipore.com. Please refer to (Cat. No. 508409) on sigmaaldrich.com.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
参考
Data Sheet

同义词: Bafilomycin A1, ≥97% by HPLC InSolution

Primary Target: vacuolar-type H⁺-ATPase

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概述

Replacement Information

重要规格表

CAS #	Empirical Formula
88899-55-2	C₃₅H₅₈O₉

价格及供货情况

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Description
Catalogue Number	508409
Brand Family	Calbiochem®
Synonyms	Bafilomycin A1, ≥97% by HPLC InSolution

References
References	Sinha, S., and Lieberburg, I. 1999. Proc. Natl. Acad. Sci. USA 96, 11049. Calvert, C.M., and Sanders, D. 1995. J. Biol. Chem. 270, 7272. Nishihara, T., et al. 1995. Biochem. Biophys. Res. Commun. 269, 255. Crider, B.P., et al. 1994. J. Biol. Chem. 269, 17379. Palokangas, H., et al. 1994. J. Biol. Chem. 269, 17577. Sundquist, K.T., and Marks, S.C., Jr. 1994. J. Bone Miner. Res. 9, 1575. Drose, S., et al. 1993. Biochemistry 32, 3902. Furuchi, T., et al. 1993. J. Biol. Chem. 268, 27345. Bowman, E.J., et al. 1988. Proc. Natl. Acad. Sci. USA 85, 7972.

References

Sinha, S., and Lieberburg, I. 1999. Proc. Natl. Acad. Sci. USA 96, 11049.
Calvert, C.M., and Sanders, D. 1995. J. Biol. Chem. 270, 7272.
Nishihara, T., et al. 1995. Biochem. Biophys. Res. Commun. 269, 255.
Crider, B.P., et al. 1994. J. Biol. Chem. 269, 17379.
Palokangas, H., et al. 1994. J. Biol. Chem. 269, 17577.
Sundquist, K.T., and Marks, S.C., Jr. 1994. J. Bone Miner. Res. 9, 1575.
Drose, S., et al. 1993. Biochemistry 32, 3902.
Furuchi, T., et al. 1993. J. Biol. Chem. 268, 27345.
Bowman, E.J., et al. 1988. Proc. Natl. Acad. Sci. USA 85, 7972.

Product Information
CAS number	88899-55-2
Form	Liquid
Formulation	A 100 µM (15 µg/241 µL) sterile-filtered solution of Bafilomycin A1, ≥97% by HPLC in 90% DMSO.
Hill Formula	C₃₅H₅₈O₉
Chemical formula	C₃₅H₅₈O₉
Hygroscopic	Hygroscopic
Quality Level	MQ100

Applications

Biological Information
Primary Target	vacuolar-type H⁺-ATPase
Purity	≥97% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Dry Ice Only
Toxicity	Standard Handling
Storage	≤ -70°C
Protect from Light	Protect from light
Hygroscopic	Hygroscopic
Avoid freeze/thaw	Avoid freeze/thaw
Do not freeze	Ok to freeze
Special Instructions	Following initial thaw, aliquot and freeze (-20°C). Aliquots are stable for up to 1 year at -20°C. Use only fresh DMSO for further dilutions.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
5.08409.0001	04055977261936

Documentation

InSolution™ Bafilomycin A1, ≥97% by HPLC - CAS 88899-55-2 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

参考

参考信息概述
Sinha, S., and Lieberburg, I. 1999. Proc. Natl. Acad. Sci. USA 96, 11049. Calvert, C.M., and Sanders, D. 1995. J. Biol. Chem. 270, 7272. Nishihara, T., et al. 1995. Biochem. Biophys. Res. Commun. 269, 255. Crider, B.P., et al. 1994. J. Biol. Chem. 269, 17379. Palokangas, H., et al. 1994. J. Biol. Chem. 269, 17577. Sundquist, K.T., and Marks, S.C., Jr. 1994. J. Bone Miner. Res. 9, 1575. Drose, S., et al. 1993. Biochemistry 32, 3902. Furuchi, T., et al. 1993. J. Biol. Chem. 268, 27345. Bowman, E.J., et al. 1988. Proc. Natl. Acad. Sci. USA 85, 7972.

参考信息概述

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	25-April-2014 JSW
Synonyms	Bafilomycin A1, ≥97% by HPLC InSolution
Description	A macrolide antibiotic that acts as a specific inhibitor of vacuolar-type H⁺-ATPase (V-type; K_i = 0.5 nM) and is a valuable tool for distinguishing among different types of ATPases. Reported to selectivity inhibit β-secretase, an enzyme involved in the processing of amyloid precursor protein (APP). Blocks lysosomal cholesterol trafficking in macrophages. Known to interfere with pH regulation in brain cells. Inhibits bone resorption both in vivo and in vitro. Has been shown to exhibit cytotoxic effects on a number of cell lines in a cell viability assay.
Form	Liquid
Formulation	A 100 µM (15 µg/241 µL) sterile-filtered solution of Bafilomycin A1, ≥97% by HPLC in 90% DMSO.
Intert gas (Yes/No)	Packaged under inert gas
CAS number	88899-55-2
Chemical formula	C₃₅H₅₈O₉
Purity	≥97% by HPLC
Storage	Protect from light Avoid freeze/thaw ≤ -70°C Hygroscopic
Do Not Freeze	Ok to freeze
Special Instructions	Following initial thaw, aliquot and freeze (-20°C). Aliquots are stable for up to 1 year at -20°C. Use only fresh DMSO for further dilutions.
Toxicity	Standard Handling
References	Sinha, S., and Lieberburg, I. 1999. Proc. Natl. Acad. Sci. USA 96, 11049. Calvert, C.M., and Sanders, D. 1995. J. Biol. Chem. 270, 7272. Nishihara, T., et al. 1995. Biochem. Biophys. Res. Commun. 269, 255. Crider, B.P., et al. 1994. J. Biol. Chem. 269, 17379. Palokangas, H., et al. 1994. J. Biol. Chem. 269, 17577. Sundquist, K.T., and Marks, S.C., Jr. 1994. J. Bone Miner. Res. 9, 1575. Drose, S., et al. 1993. Biochemistry 32, 3902. Furuchi, T., et al. 1993. J. Biol. Chem. 268, 27345. Bowman, E.J., et al. 1988. Proc. Natl. Acad. Sci. USA 85, 7972.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > ATPase/GTPase Inhibitors > ATPase Inhibitors

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