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124038 Sigma-AldrichInSolution™ Akt Inhibitor V, Triciribine - CAS 35943-35-2 - Calbiochem

The InSolution™ Akt Inhibitor V, Triciribine, also referenced under CAS 35943-35-2, controls the biological activity of Akt. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

Recommended Products

概述

Replacement Information

重要规格表

CAS #	Empirical Formula
35943-35-2	C₁₃H₁₆N₆O₄

价格及供货情况

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Description
Overview	A cell-permeable and reversible tricyclic nucleoside that selectively inhibits the cellular phosphorylation/activation of Akt1/2/3 by targeting an Akt effector molecule other than PI 3-K or PDK. Exhibits little effect towards cellular signaling pathways mediated by PKC, PKA, SGK, Stat3, p38, ERK1/2, or JNK. Shown to preferentially induce apoptosis and growth arrest in cancer cells with aberrant Akt activity both in vitro (≥60% in cell proliferation at 20 µM) and in vivo (≥80% inhibition in tumor growth in mice at 1 mg/kg/day, i.p.).
Catalogue Number	124038
Brand Family	Calbiochem®

References
References	Karst, A., et al. 2006. Cancer Res. 66, 9225. Yang, L., et al. 2004. Cancer Res. 64, 4394.

Product Information
CAS number	35943-35-2
Form	Liquid
Formulation	A 2 mg/312 µl solution of Akt Inhibitor V, Triciribine (Cat. No. 124012) in DMSO.
Hill Formula	C₁₃H₁₆N₆O₄
Chemical formula	C₁₃H₁₆N₆O₄
Hygroscopic	Hygroscopic
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Purity	≥95% by HPLC

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS
RTECS	RY8455000

Safety Information
R Phrase	R: 36/38 Irritating to eyes and skin.

Product Usage Statements

Storage and Shipping Information
Ship Code	Dry Ice Only
Toxicity	Irritant
Storage	≤ -70°C
Protect from Light	Protect from light
Hygroscopic	Hygroscopic
Avoid freeze/thaw	Avoid freeze/thaw
Do not freeze	Ok to freeze
Special Instructions	Following intitial thaw, aliquot and freeze (-70°C).

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
124038-2MGCN	04055977205848

Documentation

InSolution™ Akt Inhibitor V, Triciribine - CAS 35943-35-2 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

InSolution™ Akt Inhibitor V, Triciribine - CAS 35943-35-2 - Calbiochem 分析证书

标题	批号
124038	输入批号

参考

参考信息概述
Karst, A., et al. 2006. Cancer Res. 66, 9225. Yang, L., et al. 2004. Cancer Res. 64, 4394.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	16-January-2012 RFH
Description	A cell-permeable and reversible tricyclic nucleoside that selectively inhibits the cellular phosphorylation/activation of Akt1/2/3 by targeting an Akt effector molecule other than PI 3-K or PDK. Exhibits little effect towards cellular signaling pathways mediated by PKC, PKA, SGK, Stat3, p38, ERK1/2, or JNK. Shown to preferentially induce apoptosis and growth arrest in cancer cells with aberrant Akt activity both in vitro (≥60% in cell proliferation at 20 µM) and in vivo (≥80% inhibition in tumor growth in mice at 1 mg/kg/day, i.p.).
Form	Liquid
Formulation	A 2 mg/312 µl solution of Akt Inhibitor V, Triciribine (Cat. No. 124012) in DMSO.
Intert gas (Yes/No)	Packaged under inert gas
CAS number	35943-35-2
RTECS	RY8455000
Chemical formula	C₁₃H₁₆N₆O₄
Structure formula
Purity	≥95% by HPLC
Storage	Protect from light Avoid freeze/thaw ≤ -70°C Hygroscopic
Do Not Freeze	Ok to freeze
Special Instructions	Following intitial thaw, aliquot and freeze (-70°C).
Toxicity	Irritant
References	Karst, A., et al. 2006. Cancer Res. 66, 9225. Yang, L., et al. 2004. Cancer Res. 64, 4394.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Akt (Protein Kinase B) Inhibitors

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