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	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

124015 Sigma-AldrichInSolution™ Akt Inhibitor IV - Calbiochem

The InSolution™ Akt Inhibitor IV controls the biological activity of Akt. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

InSolution™ Akt Inhibitor IV - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
小册子
Data Sheet

Primary Target: Akt

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概述

Replacement Information

重要规格表

Empirical Formula
C₃₁H₂₇IN₄S

价格及供货情况

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Description
Catalogue Number	124015
Brand Family	Calbiochem®

References
References	Kau, T.R., et al. 2003. Cancer Cell 4, 463. Selected Citations Lee, J., et al. 2009. Cell Stem Cell 5, 76.

Product Information
ATP Competitive	N
Form	Liquid
Formulation	A 10 mM (1 mg/163 µl) solution of Akt Inhibitor IV (Cat. No. 124011) in DMSO.
Hill Formula	C₃₁H₂₇IN₄S
Chemical formula	C₃₁H₂₇IN₄S
Hygroscopic	Hygroscopic
Reversible	Y
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	Akt
Primary Target IC<sub>50</sub>	625 nM and <1.25 µM in blocking Akt-mediated FOXO1a nuclear export and cell proliferation, respectively, in 786-O cells
Purity	≥98% by HPLC
Concentration Label	Please refer to vial label for lot-specific concentration

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Shipped with Blue Ice or with Dry Ice
Toxicity	Irritant
Storage	+2°C to +8°C
Protect from Light	Protect from light
Hygroscopic	Hygroscopic
Do not freeze	Ok to freeze
Special Instructions	Following initial use, aliquot and refrigerate (4°C).

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
124015-1MGCN	07790788047986

Documentation

InSolution™ Akt Inhibitor IV - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

InSolution™ Akt Inhibitor IV - Calbiochem 分析证书

标题	批号
124015	输入批号

参考

参考信息概述
Kau, T.R., et al. 2003. Cancer Cell 4, 463. Selected Citations Lee, J., et al. 2009. Cell Stem Cell 5, 76.

小册子

标题
Akt
Biologics 31.1

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	09-April-2008 RFH
Description	A cell-permeable benzimidazole compound that inhibits Akt phosphorylation/activation presumably by targeting the ATP binding site of a kinase upstream of Akt, but downstream of PI3K. Shown to block Akt-mediated FOXO1a nuclear export (IC₅₀ = 625 nM) and cell proliferation (IC₅₀ < 1.25 µM) in 786-O cells. Unlike phosphatidylinositol analog-based Akt inhibitors (Cat. Nos. 124005, 124008, 124009), this inhibitor does not affect PI3K.
Form	Liquid
Formulation	A 10 mM (1 mg/163 µl) solution of Akt Inhibitor IV (Cat. No. 124011) in DMSO.
Intert gas (Yes/No)	Packaged under inert gas
Concentration Label	Please refer to vial label for lot-specific concentration
Chemical formula	C₃₁H₂₇IN₄S
Structure formula
Purity	≥98% by HPLC
Storage	Protect from light +2°C to +8°C Hygroscopic
Do Not Freeze	Ok to freeze
Special Instructions	Following initial use, aliquot and refrigerate (4°C).
Toxicity	Irritant
References	Kau, T.R., et al. 2003. Cancer Cell 4, 463. Selected Citations Lee, J., et al. 2009. Cell Stem Cell 5, 76.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Akt (Protein Kinase B) Inhibitors

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