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			96-Well Plate

数量	产品目录编号	订购说明	数量 / 包装	公开价
	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

508738 Sigma-AldrichInSolution™ APT1 Inhibitor, palmostatin B - Calbiochem

A 50 mM (2 mg/106.23 µL) sterile-filtered solution of APT1 Inhibitor, palmostatin B in DMSO.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
参考
Data Sheet

同义词: APT1 Inhibitor

Primary Target: APT1

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概述

Replacement Information

重要规格表

Empirical Formula
C₂₃H₃₆O₄

价格及供货情况

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Description
Catalogue Number	508738
Brand Family	Calbiochem®
Synonyms	APT1 Inhibitor

References
References	Dekker, F. and Hedberg, C. 2011. Bioorg. Med. Chem. Lett. 19, 1376. Dekker, F., et al. 2010. Nat. Chem. Biol. 6, 449.

Product Information
Form	Liquid
Formulation	A 50 mM (2 mg/106.23 µL) sterile-filtered solution of APT1 Inhibitor, palmostatin B (Cat. No. 178501). in DMSO.
Hill Formula	C₂₃H₃₆O₄
Chemical formula	C₂₃H₃₆O₄
Hygroscopic	Hygroscopic
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	APT1
Purity	≥95% by HPLC

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Dry Ice Only
Toxicity	Standard Handling
Storage	≤ -70°C
Protect from Light	Protect from light
Hygroscopic	Hygroscopic
Avoid freeze/thaw	Avoid freeze/thaw
Do not freeze	Ok to freeze
Special Instructions	Following initial thaw, aliquot and freeze (-20°C). Aliquots are stable for up to 3 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
5.08738.0001	04055977261356

Documentation

InSolution™ APT1 Inhibitor, palmostatin B - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

参考

参考信息概述
Dekker, F. and Hedberg, C. 2011. Bioorg. Med. Chem. Lett. 19, 1376. Dekker, F., et al. 2010. Nat. Chem. Biol. 6, 449.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	28-March-2014 JSW
Synonyms	APT1 Inhibitor
Description	A cell-permeable, beta-lactone acyl protein thioesterase 1 (APT1) inhibitor (IC₅₀ = 0.67 µM, in an enzymatic assay) that is shown to specifically block Ras depalmitoylation, without affecting Ras acylation, in MDCK cells, both in vitro and in vivo. It induces a marked redistribution of NRas to endomembranes (1 µM) without notable cytotoxicity, and is shown to elicit a loss of the precise steady-state localization of palmitoylated Ras proteins in the same cell line. At 50 µM, this inhibitor displays a partial phenotypic reversion in oncogenic HRasG12V-transformed fibroblasts. Furthermore, it demonstrates selectivity for APT1 over phospholipase A1, A2, Cβ and D. It's inhibitory effect is demonstrated to be consistent with that of APT1 downregulation by siRNA.
Form	Liquid
Formulation	A 50 mM (2 mg/106.23 µL) sterile-filtered solution of APT1 Inhibitor, palmostatin B (Cat. No. 178501). in DMSO.
Intert gas (Yes/No)	Packaged under inert gas
Chemical formula	C₂₃H₃₆O₄
Structure formula
Purity	≥95% by HPLC
Storage	Protect from light Avoid freeze/thaw ≤ -70°C Hygroscopic
Do Not Freeze	Ok to freeze
Special Instructions	Following initial thaw, aliquot and freeze (-20°C). Aliquots are stable for up to 3 months at -20°C.
Toxicity	Standard Handling
References	Dekker, F. and Hedberg, C. 2011. Bioorg. Med. Chem. Lett. 19, 1376. Dekker, F., et al. 2010. Nat. Chem. Biol. 6, 449.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Other Inhibitors of Biological Interest

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