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171261 Sigma-AldrichInSolution™ AMPK Inhibitor, Compound C - CAS 866405-64-3 - Calbiochem

InSolution™ AMPK Inhibitor, Compound C, CAS 866405-64-3, is a 10 mM (1 mg/250 µl) solution of AMPK Inhibitor, Compound C (Cat. No. 171260) in DMSO.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: Dorsomorphin, BMP Inhibitor I, AMPK Inhibitor I

Primary Target: AMPK

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概述

Replacement Information

重要规格表

CAS #	Empirical Formula
866405-64-3	C₂₄H₂₅N₅O

价格及供货情况

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Description
Overview	A cell-permeable pyrrazolopyrimidine compound that inhibits against KDR/VEGFR2, ALK2/BMPR-I, AMPK kinase activity (IC₅₀ = 25.1, 148, and 234.6 nM, respectively), while exhibiting much reduced or little effect toward ALK5/TGFβR-I, ZAPK, Syk, PKCθ, PKA, or JAK3. Shown to block both BMP pathway-dependent dorsoventral development (EC₁₀₀ = 2.5 µM) and VEGF signaling-dependent intersomitic vessel formation (EC₅₀ = 5 µM) in zebrafish embryo in vivo. Commonly used in combination with AMPK activators AICAR (Cat. No. 123040) and/or Metformin (Cat. No. 317240) for studying AMPK-dependent cellular events in vitro and physiological responses in animals in vivo.
Catalogue Number	171261
Brand Family	Calbiochem®
Synonyms	Dorsomorphin, BMP Inhibitor I, AMPK Inhibitor I

References
References	Hao, J., et al. 2010. ACS Chem.Biol. 5, 245. Kim, E.K., et al. 2004. J. Biol. Chem. 279, 19970. Lee, M., et al. 2003. J. Biol. Chem. 278, 39653. Inoki, K., et al. 2003. Cell 115, 577. Fryer, L.G., 2002. FEBS Lett. 531, 189. Zhou, G., et al. 2001. J. Clin. Invest. 108, 1167.

Product Information
CAS number	866405-64-3
ATP Competitive	Y
Form	Liquid
Formulation	Supplied as a 10 mM (1 mg/250 µl) solution of AMPK Inhibitor, Compound C (Cat. No. 171260) in DMSO.
Hill Formula	C₂₄H₂₅N₅O
Chemical formula	C₂₄H₂₅N₅O
Hygroscopic	Hygroscopic
Reversible	Y
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	AMPK
Primary Target IC<sub>50</sub>	25.1, 148, and 234.6 nM, against KDR/VEGFR2, ALK2/BMPR-I, AMPK kinase activity, respectively
Primary Target K<sub>i</sub>	EC100 = 2.5 µM against BMP pathway-dependent dorsoventral development; EC50 = 5 µM against VEGF signaling-dependent intersomitic vessel formation in zebrafish embryo in vivo
Purity	≥95% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Shipped with Blue Ice or with Dry Ice
Toxicity	Irritant
Storage	+2°C to +8°C
Protect from Light	Protect from light
Hygroscopic	Hygroscopic
Do not freeze	Ok to freeze
Special Instructions	Following initial use, aliquot and freeze (-20°C). Once opened, stock solutions are stable for up to 3 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
171261-1MGCN	04055977207170

Documentation

InSolution™ AMPK Inhibitor, Compound C - CAS 866405-64-3 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

InSolution™ AMPK Inhibitor, Compound C - CAS 866405-64-3 - Calbiochem 分析证书

标题	批号
171261	输入批号

参考

参考信息概述
Hao, J., et al. 2010. ACS Chem.Biol. 5, 245. Kim, E.K., et al. 2004. J. Biol. Chem. 279, 19970. Lee, M., et al. 2003. J. Biol. Chem. 278, 39653. Inoki, K., et al. 2003. Cell 115, 577. Fryer, L.G., 2002. FEBS Lett. 531, 189. Zhou, G., et al. 2001. J. Clin. Invest. 108, 1167.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	22-March-2012 JSW
Synonyms	Dorsomorphin, BMP Inhibitor I, AMPK Inhibitor I
Description	A cell-permeable pyrrazolopyrimidine compound that inhibits against KDR/VEGFR2, ALK2/BMPR-I, AMPK kinase activity (IC₅₀ = 25.1, 148, and 234.6 nM, respectively), while exhibiting much reduced or little effect toward ALK5/TGFβR-I, ZAPK, Syk, PKCθ, PKA, or JAK3. Shown to block both BMP pathway-dependent dorsoventral development (EC₁₀₀ = 2.5 µM) and VEGF signaling-dependent intersomitic vessel formation (EC₅₀ = 5 µM) in zebrafish embryo in vivo. Commonly used in combination with AMPK activators AICAR (Cat. No. 123040) and/or Metformin (Cat. No. 317240) for studying AMPK-dependent cellular events in vitro and physiological responses in animals in vivo.
Form	Liquid
Formulation	Supplied as a 10 mM (1 mg/250 µl) solution of AMPK Inhibitor, Compound C (Cat. No. 171260) in DMSO.
Intert gas (Yes/No)	Packaged under inert gas
CAS number	866405-64-3
Chemical formula	C₂₄H₂₅N₅O
Structure formula
Purity	≥95% by HPLC
Storage	Protect from light +2°C to +8°C Hygroscopic
Do Not Freeze	Ok to freeze
Special Instructions	Following initial use, aliquot and freeze (-20°C). Once opened, stock solutions are stable for up to 3 months at -20°C.
Toxicity	Irritant
References	Hao, J., et al. 2010. ACS Chem.Biol. 5, 245. Kim, E.K., et al. 2004. J. Biol. Chem. 279, 19970. Lee, M., et al. 2003. J. Biol. Chem. 278, 39653. Inoki, K., et al. 2003. Cell 115, 577. Fryer, L.G., 2002. FEBS Lett. 531, 189. Zhou, G., et al. 2001. J. Clin. Invest. 108, 1167.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > AMPK Inhibitors

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