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			96-Well Plate

数量	产品目录编号	订购说明	数量 / 包装	公开价
	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

208750 Sigma-AldrichInSolution™ ALLN - CAS 110044-82-1 - Calbiochem

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
小册子
Data Sheet
Citations

同义词: Calpain Inhibitor I, LLNL, MG 101, Proteasome Inhibitor V

Primary Target: calpain 1

Recommended Products

概述

Replacement Information

重要规格表

CAS #	Empirical Formula
110044-82-1	C₂₀H₃₇N₃O₄

价格及供货情况

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Description
Catalogue Number	208750
Brand Family	Calbiochem®
Synonyms	Calpain Inhibitor I, LLNL, MG 101, Proteasome Inhibitor V

References
References	Milligan, S.A., et al. 1996. Arch. Biochem. Biophys. 335, 388. Griscavage, J.M., et al. 1995. Biochem. Biophys. Res. Commun. 215, 721. Squier, M.K., et al. 1994. J. Cell Physiol. 159, 229. Rami, J., and Kreiglstein, J. 1993. Brain Res. 609, 67.

Product Information
CAS number	110044-82-1
ATP Competitive	N
Form	Clear colorless solution
Formulation	A 10 mM (5 mg/1.30 ml) solution of ALLN (Cat. No. 208719) in DMSO.
Hill Formula	C₂₀H₃₇N₃O₄
Chemical formula	C₂₀H₃₇N₃O₄
Reversible	N
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	calpain 1
Primary Target K<sub>i</sub>	190 nM, 220 nM, 150 nM, 500 pM, against calpain I, calpain II, cathepsin B, and cathepsin L, respectively
Purity	≥95% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information
R Phrase	R: 36/38 Irritating to eyes and skin.
S Phrase	S: 26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.

Product Usage Statements

Storage and Shipping Information
Ship Code	Blue Ice Only
Toxicity	Flammable
Storage	-20°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following initial thaw, aliquot and freeze (-20°C).

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
208750-5MGCN	04055977202847

Documentation

InSolution™ ALLN - CAS 110044-82-1 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

InSolution™ ALLN - CAS 110044-82-1 - Calbiochem 分析证书

标题	批号
208750	输入批号

参考

参考信息概述
Milligan, S.A., et al. 1996. Arch. Biochem. Biophys. 335, 388. Griscavage, J.M., et al. 1995. Biochem. Biophys. Res. Commun. 215, 721. Squier, M.K., et al. 1994. J. Cell Physiol. 159, 229. Rami, J., and Kreiglstein, J. 1993. Brain Res. 609, 67.

小册子

标题
Caspases and other Apoptosis Related Tools Brochure

引用

标题

Ping Han, et al. (2005) Suppression of Cyclin-Dependent Kinase 5 Activation by Amyloid Precursor Protein: A Novel Excitoprotective Mechanism Involving Modulation of Tau Phosphorylation. Journal of Neuroscience 25, 11542-11552.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	28-May-2008 RFH
Synonyms	Calpain Inhibitor I, LLNL, MG 101, Proteasome Inhibitor V
Description	A 10 mM solution of ALLN (Cat. No. 208719) in anhydrous DMSO. Inhibitor of calpain I (K_i = 190 nM), calpain II (K_i = 220 nM), cathepsin B (K_i = 150 nM), and cathepsin L (K_i = 0.5 nM). Inhibits neutral cysteine proteases and proteasome (K_i = 6 µM). Protects against neuronal damage caused by hypoxia and ischemia. Inhibits apoptosis in thymocytes and metamyelocytes. Inhibits cell cycle progression at the G₁/S border and metaphase/anaphase in CHO cells by inhibiting cyclin B degradation. Also prevents nitric oxide production by activated macrophages by interfering with transcription of the inducible nitric oxide synthase gene. Inhibits the proteolysis of IkB-α and IkB-β by the ubiquitin-proteasome complex.
Form	Clear colorless solution
Formulation	A 10 mM (5 mg/1.30 ml) solution of ALLN (Cat. No. 208719) in DMSO.
Intert gas (Yes/No)	Packaged under inert gas
CAS number	110044-82-1
Chemical formula	C₂₀H₃₇N₃O₄
Structure formula
Purity	≥95% by HPLC
Storage	Protect from light -20°C
Do Not Freeze	Ok to freeze
Special Instructions	Following initial thaw, aliquot and freeze (-20°C).
Toxicity	Flammable
References	Milligan, S.A., et al. 1996. Arch. Biochem. Biophys. 335, 388. Griscavage, J.M., et al. 1995. Biochem. Biophys. Res. Commun. 215, 721. Squier, M.K., et al. 1994. J. Cell Physiol. 159, 229. Rami, J., and Kreiglstein, J. 1993. Brain Res. 609, 67.
Citation	Ping Han, et al. (2005) Suppression of Cyclin-Dependent Kinase 5 Activation by Amyloid Precursor Protein: A Novel Excitoprotective Mechanism Involving Modulation of Tau Phosphorylation. Journal of Neuroscience 25, 11542-11552.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Proteases Inhibitors

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Proteases Inhibitors > Calpain Inhibitors

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