数量	产品目录编号	订购说明	数量 / 包装	公开价
			96-Well Plate

数量	产品目录编号	订购说明	数量 / 包装	公开价
	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

658411 Sigma-AldrichInSolution™ AG490 - Calbiochem

InSolution™ AG490 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: JAK1 Inhibitor II, JAK2 Inhibitor VI, JAK3 Inhibitor XI

View Products on Sigmaaldrich.com

Recommended Products

概述

Replacement Information

重要规格表

Empirical Formula
C₁₇H₁₄N₂O₃

价格及供货情况

产品目录编号	库存情况	包装	数量 / 包装	价格	数量
658411-5MGCN	正在查询供货情况...... — 目前缺货有货停产少量现货供货情况有待确认登录查看库存有货目前缺货有货其余：另行通知其余：另行通知另行通知联系客户服务 Contact Customer Service 联系客户服务联系客户服务	塑胶安瓿;塑胶针药瓶	5 mg	正在检索价格...... 无法检索价格。最小订购数量为倍数 Maximum Quantity is 以订单确认为准更多信息您节约了 ()。 — Request Pricing 登录查看价格	查看库存情况 —	添加到收藏夹添加到收藏夹添加到我的收藏夹

Description
Catalogue Number	658411
Brand Family	Calbiochem®
Synonyms	JAK1 Inhibitor II, JAK2 Inhibitor VI, JAK3 Inhibitor XI

References
References	Jaleel, M., et al. 2004. Biochemistry 43, 8247. Eriksen, K.W., et al. 2001. Leukemia 15, 787. Kirken, R.A., et al. 1999. Leukoc. Biol. 65, 891. Nielsen, M., et al. 1997. Proc. Natl. Acad. Sci. USA 94, 6764. Meydan, N., et al. 1996. Nature 379, 645. Gazit, A., et al. 1991. J. Med. Chem. 34, 1896. Levitzki, A. 1990. Biochem. Pharmacol. 40, 913.

Product Information
Form	Liquid
Formulation	A 100 mM (5 mg/170 µl) solution of AG490 (Cat. No. 658401) in DMSO.
Hill Formula	C₁₇H₁₄N₂O₃
Chemical formula	C₁₇H₁₄N₂O₃
Hygroscopic	Hygroscopic
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Purity	≥98% by HPLC

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information
R Phrase	R: 36/38 Irritating to eyes and skin.
S Phrase	S: 26-36-45 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).

Product Usage Statements

Storage and Shipping Information
Ship Code	Dry Ice Only
Toxicity	Irritant
Storage	≤ -70°C
Protect from Light	Protect from light
Hygroscopic	Hygroscopic
Do not freeze	Ok to freeze
Special Instructions	Following initial thaw, aliquot and freeze (-70°C). Once opened, stock solution is stable for up to 6 months at -70°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
658411-5MGCN	04055977261608

Documentation

InSolution™ AG490 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

InSolution™ AG490 - Calbiochem 分析证书

标题	批号
658411	输入批号

参考

参考信息概述
Jaleel, M., et al. 2004. Biochemistry 43, 8247. Eriksen, K.W., et al. 2001. Leukemia 15, 787. Kirken, R.A., et al. 1999. Leukoc. Biol. 65, 891. Nielsen, M., et al. 1997. Proc. Natl. Acad. Sci. USA 94, 6764. Meydan, N., et al. 1996. Nature 379, 645. Gazit, A., et al. 1991. J. Med. Chem. 34, 1896. Levitzki, A. 1990. Biochem. Pharmacol. 40, 913.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	20-November-2008 JSW
Synonyms	JAK1 Inhibitor II, JAK2 Inhibitor VI, JAK3 Inhibitor XI
Description	Potent inhibitor of epidermal growth factor receptor kinase autophosphorylation (IC₅₀ = 100 nM). Jak family tyrosine kinase inhibitor. Inhibition of Jak2 by AG 490 selectively blocks leukemic cell growth in vitro and in vivo by inducing programmed cell death, with no harmful effect on normal haematopoiesis. Inhibits the constitutive activation of STAT-3 and IL-2-induced growth of MF tumor cells. AG 490 has also been shown to inhibit the autokinase activity of JAK3. Also reported to inhibit guanylyl cyclase.
Form	Liquid
Formulation	A 100 mM (5 mg/170 µl) solution of AG490 (Cat. No. 658401) in DMSO.
Intert gas (Yes/No)	Packaged under inert gas
Chemical formula	C₁₇H₁₄N₂O₃
Structure formula
Purity	≥98% by HPLC
Storage	Protect from light ≤ -70°C Hygroscopic
Do Not Freeze	Ok to freeze
Special Instructions	Following initial thaw, aliquot and freeze (-70°C). Once opened, stock solution is stable for up to 6 months at -70°C.
Toxicity	Irritant
References	Jaleel, M., et al. 2004. Biochemistry 43, 8247. Eriksen, K.W., et al. 2001. Leukemia 15, 787. Kirken, R.A., et al. 1999. Leukoc. Biol. 65, 891. Nielsen, M., et al. 1997. Proc. Natl. Acad. Sci. USA 94, 6764. Meydan, N., et al. 1996. Nature 379, 645. Gazit, A., et al. 1991. J. Med. Chem. 34, 1896. Levitzki, A. 1990. Biochem. Pharmacol. 40, 913.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Protein Tyrosine Kinase (PTK) Inhibitors

此产品已添加到您的购物车。