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			96-Well Plate

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	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

658548 Sigma-AldrichInSolution™ AG 1478 - CAS 175178-82-2 - Calbiochem

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet
Citations

Primary Target: Epidermal growth factor receptor kinase

Recommended Products

概述

Replacement Information

重要规格表

CAS #	Empirical Formula
175178-82-2	C₁₆H₁₄ClN₃O₂

价格及供货情况

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Description
Catalogue Number	658548
Brand Family	Calbiochem®

References
References	Levitski, A., and Gazit, A. 1995. Science 267, 1782. Fry, D.W., et al. 1994. Science 265, 1093. Osherov, N., and Levitski, A. 1994. Eur. J. Biochem. 225, 1047. Ward, W.H., et al. 1994. Biochem. Pharmacol. 48, 659.

Product Information
CAS number	175178-82-2
ATP Competitive	Y
Declaration	Sold under license of U.S. Patent 5,457,105 and European Patent 0,566,266.
Form	Clear to faint tan liquid
Formulation	A 10 mM (1 mg/317 µl) solution of AG 1478 (Cat. No. 658552) in DMSO.
Hill Formula	C₁₆H₁₄ClN₃O₂
Chemical formula	C₁₆H₁₄ClN₃O₂
Reversible	Y
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	Epidermal growth factor receptor kinase
Primary Target IC<sub>50</sub>	3 nM against of epidermal growth factor receptor kinase
Purity	≥98% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information
R Phrase	R: 36/38 Irritating to eyes and skin.
S Phrase	S: 26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.

Product Usage Statements

Storage and Shipping Information
Ship Code	Blue Ice Only
Toxicity	Irritant
Storage	-20°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following initial thaw, aliquot and freeze (-20°C).

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
658548-1MGCN	04055977261646

Documentation

InSolution™ AG 1478 - CAS 175178-82-2 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

InSolution™ AG 1478 - CAS 175178-82-2 - Calbiochem 分析证书

标题	批号
658548	输入批号

参考

参考信息概述
Levitski, A., and Gazit, A. 1995. Science 267, 1782. Fry, D.W., et al. 1994. Science 265, 1093. Osherov, N., and Levitski, A. 1994. Eur. J. Biochem. 225, 1047. Ward, W.H., et al. 1994. Biochem. Pharmacol. 48, 659.

引用

标题

Farahdiba Jafri, et al. (2006) Constitutive ERK1/2 activation by a chimeric neurokinin NK1 receptor-beta-arrestin1 fusion protein: Probing the composition and function of the G protein-coupled receptor 'signalsome'. Journal of Biological Chemistry in press,.

Ying-Hong Feng, et al. (2005) Unconventional Homologous Internalization of the Angiotensin II Type-1 Receptor Induced by G-Protein-Independent Signals. Hypertension 46, 419-423.

Diane Gesty-Palmer, et al. (2005) b-Arrestin 2 expression determines the transcriptional response to lysophosphatidic acid stimulation in murine embryo fibroblasts. Journal of Biological Chemistry 280, 32157-32167.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	15-September-2008 RFH
Description	Highly potent and specific inhibitor of the epidermal growth factor (EGF) receptor tyrosine kinase (IC₅₀ = 3 nM). Much higher concentrations are required for inhibition of the kinase activity of the closely related HER2 (neu/erb-B2) receptor (IC₅₀ > 100 µM), the platelet-derived growth factor (PDGF) receptor (IC₅₀ > 100 µM), and p210^Bcr-Abl (IC₅₀ >50 µM). Its mechanism of inhibition likely mimics that of the related compound, 4-(3-chloroanilino)quinazoline (CAQ), a competitive inhibitor with respect to ATP.
Form	Clear to faint tan liquid
Formulation	A 10 mM (1 mg/317 µl) solution of AG 1478 (Cat. No. 658552) in DMSO.
Intert gas (Yes/No)	Packaged under inert gas
CAS number	175178-82-2
Chemical formula	C₁₆H₁₄ClN₃O₂
Structure formula
Purity	≥98% by HPLC
Storage	Protect from light -20°C
Do Not Freeze	Ok to freeze
Special Instructions	Following initial thaw, aliquot and freeze (-20°C).
Toxicity	Irritant
References	Levitski, A., and Gazit, A. 1995. Science 267, 1782. Fry, D.W., et al. 1994. Science 265, 1093. Osherov, N., and Levitski, A. 1994. Eur. J. Biochem. 225, 1047. Ward, W.H., et al. 1994. Biochem. Pharmacol. 48, 659.
Citation	Farahdiba Jafri, et al. (2006) Constitutive ERK1/2 activation by a chimeric neurokinin NK1 receptor-beta-arrestin1 fusion protein: Probing the composition and function of the G protein-coupled receptor 'signalsome'. Journal of Biological Chemistry in press,. Ying-Hong Feng, et al. (2005) Unconventional Homologous Internalization of the Angiotensin II Type-1 Receptor Induced by G-Protein-Independent Signals. Hypertension 46, 419-423. Diane Gesty-Palmer, et al. (2005) b-Arrestin 2 expression determines the transcriptional response to lysophosphatidic acid stimulation in murine embryo fibroblasts. Journal of Biological Chemistry 280, 32157-32167.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Protein Tyrosine Kinase (PTK) Inhibitors

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