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			96-Well Plate

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	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

401002 Sigma-AldrichIberiotoxin, Buthus tamulus, Recombinant, E. coli - CAS 129203-60-7 - Calbiochem

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: rlbTx, Pyr-FTDVDCSVSKECWSVCKDLFGVDRGKCMGKKCRCYQ

Primary Target: High conductance Ca2+-activated K+ channels

Recommended Products

概述

Replacement Information

重要规格表

CAS #
129203-60-7

价格及供货情况

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Description
Overview	Recombinant Buthus tamulus iberiotoxin expressed in E. coli. Acts as a selective, reversible blocker of high conductance Ca²⁺-activated K⁺ channels (IC₅₀ = 250 pM).
Catalogue Number	401002
Brand Family	Calbiochem®
Synonyms	rlbTx, Pyr-FTDVDCSVSKECWSVCKDLFGVDRGKCMGKKCRCYQ

References
References	Vanelli, G., et al. 1994. J. Appl. Physiol. 76, 1098. Garcia, M.L., et al. 1991. J. Bioeng. Biomembr. 23, 615. Galvez, A., et al. 1990. J. Biol. Chem. 265, 11083.

Product Information
CAS number	129203-60-7
ATP Competitive	N
Form	Salt-free lyophilized solid
Reversible	Y
Quality Level	MQ100

Applications

Biological Information
Biological activity	potently inhibits Ca²⁺-activated K⁺ channels expressed in Xenopus oocytes
Primary Target	High conductance Ca2+-activated K+ channels
Primary Target IC<sub>50</sub>	250 pM against high conductance Ca2+-activated K+ channels
Purity	≥98% by HPLC

Physicochemical Information
Cell permeable	N
Peptide Sequence	Pyr-Phe-Thr-Asp-Val-Asp-Cys⁷-Ser-Val-Ser-Lys-Glu-Cys¹³-Trp-Ser-Val-Cys¹⁷-Lys-Asp-Leu-Phe-Gly-Val-Asp-Arg-Gly-Lys-Cys²⁸-Met-Gly-Lys-Lys-Cys³³-Arg-Cys³⁵-Tyr-Gln-OH (disulfide bonds: 7 →28; 13 → 35; 17 → 33)

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information
R Phrase	R: 20/21/22 Harmful by inhalation, in contact with skin and if swallowed.
S Phrase	S: 36 Wear suitable protective clothing.

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Harmful
Storage	-20°C
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C) for long-term storage or refrigerate (4°C) for short-term storage. Stock solutions are stable for up to 3 months at -20°C or up to 2 weeks at 4°C.

Packaging Information

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
401002-10UGCN	04055977189360

Documentation

Iberiotoxin, Buthus tamulus, Recombinant, E. coli - CAS 129203-60-7 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

Iberiotoxin, Buthus tamulus, Recombinant, E. coli - CAS 129203-60-7 - Calbiochem 分析证书

标题	批号
401002	输入批号

参考

参考信息概述
Vanelli, G., et al. 1994. J. Appl. Physiol. 76, 1098. Garcia, M.L., et al. 1991. J. Bioeng. Biomembr. 23, 615. Galvez, A., et al. 1990. J. Biol. Chem. 265, 11083.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	14-July-2008 RFH
Synonyms	rlbTx, Pyr-FTDVDCSVSKECWSVCKDLFGVDRGKCMGKKCRCYQ
Description	Recombinant Buthus tamulus iberiotoxin expressed in E. coli. A single polypeptide chain of 37 amino acids that displays about 68% sequence homology with charybdotoxin (ChTx). Acts as a selective, reversible blocker of high conductance, Ca²⁺-activated K⁺ channels (PK,Ca). rIbTx does not block other types of voltage-dependent ion channels, especially other types of K⁺ channels that are sensitive to inhibition by ChTx. Shown to block PK,Ca in excised membrane patches from bovine aortic smooth muscle, acting exclusively at the outer face of the channel (IC₅₀ = 250 pM). Causes a decrease in probability of channel opening and the channel open mean time. rIbTx appears to modulate ChTx binding by an allosteric mechanism.
Form	Salt-free lyophilized solid
CAS number	129203-60-7
Peptide Sequence	Pyr-Phe-Thr-Asp-Val-Asp-Cys⁷-Ser-Val-Ser-Lys-Glu-Cys¹³-Trp-Ser-Val-Cys¹⁷-Lys-Asp-Leu-Phe-Gly-Val-Asp-Arg-Gly-Lys-Cys²⁸-Met-Gly-Lys-Lys-Cys³³-Arg-Cys³⁵-Tyr-Gln-OH (disulfide bonds: 7 →28; 13 → 35; 17 → 33)
Purity	≥98% by HPLC
Biological activity	potently inhibits Ca²⁺-activated K⁺ channels expressed in Xenopus oocytes
Solubility	Reconstitute in Tris-buffered saline (100 mM NaCl, 10 mM Tris-HCl, pH 7.5) containing 0.1% BSA.
Storage	-20°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C) for long-term storage or refrigerate (4°C) for short-term storage. Stock solutions are stable for up to 3 months at -20°C or up to 2 weeks at 4°C.
Toxicity	Harmful
References	Vanelli, G., et al. 1994. J. Appl. Physiol. 76, 1098. Garcia, M.L., et al. 1991. J. Bioeng. Biomembr. 23, 615. Galvez, A., et al. 1990. J. Biol. Chem. 265, 11083.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Neurochemicals > Channel Blockers > Potassium Channel Blockers

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