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406170 Sigma-AldrichIP6K Inhibitor - CAS 519178-28-0 - Calbiochem

The IP6K Inhibitor, also referenced under CAS 519178-28-0, controls the biological activity of IP6K.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: N²-(m-Trifluorobenzyl), N⁶-(p-nitrobenzyl)purine, Inositol-1,4,5-trisphosphate 3-Kinase Inhibitor, IP3K Inhibitor, Kcs1 Inhibitor, TNP

Primary Target: IP 3-K

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概述

Replacement Information

重要规格表

CAS #	Empirical Formula
519178-28-0	C₂₀H₁₆F₃N₇O₂

价格及供货情况

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Description
Overview	A cell-permeable 2,6-disubstituted purine compound that, although originally identified as a reversible, ATP-competitive inhibitor against the conversion of Ins(1,4,5)P₃ (Cat. Nos. 407123 & 407137) to Ins(1,3,4,5)P₄ (Cat. No. 407126) by IP3K (IC₅₀ = 18 µM; [ATP] = 10 μM), acts in fact as a much more effective inhibitor against the IP6K1/2/3-catalyzed conversion of InsP₆ (Cat. No. 407125) to 5-[PP]- InsP₆ or InsP₇ (IC₅₀ = 0.47 μM against IP6K1; [ATP] = 1 mM) due to a much higher affinity of ATP toward IP3K than IP6K (K_m of ATP for the respective enzymes = 0.01 vs 1000 μM). Shown to potently inhibit cellular InsP₇ level (IC₅₀ = 0.55 μM in HeLa cultures), while being less potent in increasing the cellular InsP₃ accumulation (>10 µM in HeLa cultures). TNP is also effective against S. cerevisiae IP6K, Kcs1, but not Vip/PPIP5Ks, enzymes that catalyze the pyrophosphorylation at the 1/3 position of InsP₆ and InsP₇, in either human or yeast species or two other IP3 metabolizing enzymes, PLC and IP3 5-ppase.
Catalogue Number	406170
Brand Family	Calbiochem®
Synonyms	N²-(m-Trifluorobenzyl), N⁶-(p-nitrobenzyl)purine, Inositol-1,4,5-trisphosphate 3-Kinase Inhibitor, IP3K Inhibitor, Kcs1 Inhibitor, TNP

References
References	Padmanabhan, U., et al. 2009. J. Biol. Chem. 284, 10571. Chang, Y.T., et al. 2002. ChemBioChem 3, 897.

Product Information
CAS number	519178-28-0
ATP Competitive	Y
Form	Yellow solid
Hill Formula	C₂₀H₁₆F₃N₇O₂
Chemical formula	C₂₀H₁₆F₃N₇O₂
Reversible	Y
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	IP 3-K
Primary Target IC<sub>50</sub>	0.47 µM against IP6K1; [ATP] = 1 mM; 18 µM against the conversion of Ins(1,4,5)P3 to Ins(1,3,4,5)P4 by IP3K; [ATP] = 10 µM
Purity	≥95% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	+2°C to +8°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
406170-5MGCN	04055977188530

Documentation

IP6K Inhibitor - CAS 519178-28-0 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

IP6K Inhibitor - CAS 519178-28-0 - Calbiochem 分析证书

标题	批号
406170	输入批号

参考

参考信息概述
Padmanabhan, U., et al. 2009. J. Biol. Chem. 284, 10571. Chang, Y.T., et al. 2002. ChemBioChem 3, 897.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	23-February-2011 JSW
Synonyms	N²-(m-Trifluorobenzyl), N⁶-(p-nitrobenzyl)purine, Inositol-1,4,5-trisphosphate 3-Kinase Inhibitor, IP3K Inhibitor, Kcs1 Inhibitor, TNP
Description	A cell-permeable 2,6-disubstituted purine compound that, although originally identified as a reversible, ATP-competitive inhibitor against the conversion of Ins(1,4,5)P₃ (Cat. Nos. 407123 & 407137) to Ins(1,3,4,5)P₄ (Cat. No. 407126) by IP3K (IC₅₀ = 18 µM; [ATP] = 10 μM), acts in fact as a much more effective inhibitor against the IP6K1/2/3-catalyzed conversion of InsP₆ (Cat. No. 407125) to 5-[PP]- InsP₆ or InsP₇ (IC₅₀ = 0.47 μM against IP6K1; [ATP] = 1 mM) due to a much higher affinity of ATP toward IP3K than IP6K (K_m of ATP for the respective enzymes = 0.01 vs 1000 μM). Shown to potently inhibit cellular InsP₇ level (IC₅₀ = 0.55 μM in HeLa cultures), while being less potent in increasing the cellular InsP₃ accumulation (>10 µM in HeLa cultures). TNP is also effective against S. cerevisiae IP6K, Kcs1, but not Vip/PPIP5Ks, enzymes that catalyze the pyrophosphorylation at the 1/3 position of InsP₆ and InsP₇, in either human or yeast species or two other IP3 metabolizing enzymes, PLC and IP3 5-ppase.
Form	Yellow solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	519178-28-0
Chemical formula	C₂₀H₁₆F₃N₇O₂
Structure formula
Purity	≥95% by HPLC
Solubility	DMSO (10 mg/ml) or Methanol (5 mg/ml)
Storage	Protect from light +2°C to +8°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity	Standard Handling
References	Padmanabhan, U., et al. 2009. J. Biol. Chem. 284, 10571. Chang, Y.T., et al. 2002. ChemBioChem 3, 897.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Lipid Signaling Inhibitors > IP3 Kinase Inhibitors

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