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ILK inhibitor, Cpd 22, is a cell-permeable, potent & specific inhibitor of integrin-linked kinase (ILK; IC50 = 600 nM) with anti-proliferative potency against prostrate & breast cancer cell lines.
More>>ILK inhibitor, Cpd 22, is a cell-permeable, potent & specific inhibitor of integrin-linked kinase (ILK; IC50 = 600 nM) with anti-proliferative potency against prostrate & breast cancer cell lines. Less<<
ILK inhibitor, Cpd 22 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
A cell-permeable, tri-substituted pyrazol compound that acts as a potent and specific integrin-linked kinase (ILK) inhibitor (IC50 = 600 nM). Shown to have high in vitro anti-proliferative potency against prostrate and breast cancer cell lines (IC50 = 1 to 2.5 µM) while sparing normal epithelial cells. Its effect on cancer cells have been attributed to induction of autophagy and apoptosis. Suppresses ILK-mediated phosphorylation of Akt at Ser473 site, thereby down-regulating the downstream targets, such as GSK-3b and myosin light chain. Also causes a transcriptional repression of the transcription factor Y-Box binding protein 1 (YB-1). Exhibits minimum toxicity in mouse model.
ILK inhibitor, Cpd 22, is a cell-permeable, potent & specific inhibitor of integrin-linked kinase (ILK; IC50 = 600 nM) with anti-proliferative potency against prostrate & breast cancer cell lines.
Biological Information
Purity
≥94% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code
Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity
Standard Handling
Storage
+2°C to +8°C
Protect from Light
Protect from light
Do not freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas
Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
产品目录编号
GTIN
407331-5MGCN
04055977188356
Documentation
ILK inhibitor, Cpd 22 - Calbiochem 分析证书
标题
批号
407331
参考
参考信息概述
Lee, S., et al. 2011. J. Med. Chem.54, 6364
数据表
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
Revision
03-August-2016 JSW
Description
A cell-permeable, tri-substituted pyrazol compound that acts as a potent and specific integrin-linked kinase (ILK) inhibitor (IC50 = 600 nM). Shown to have high in vitro anti-proliferative potency against prostrate and breast cancer cell lines (IC50 = 1 to 2.5 mM) while sparing normal epithelial cells. Its effect on cancer cells have been attributed to induction of autophagy and apoptosis. Suppresses ILK-mediated phosphorylation of Akt at Ser473 site, thereby down-regulating the downstream targets, such as GSK-3b and myosin light chain. Also causes a transcriptional repression of the transcription factor Y-Box binding protein 1 (YB-1). Exhibits minimum toxicity in mouse model.
Form
Off-white powder
Intert gas (Yes/No)
Packaged under inert gas
Chemical formula
C₃₀H₃₀F₃N₅O
Purity
≥94% by HPLC
Solubility
DMSO (100 mg/ml)
Storage
Protect from light
+2°C to +8°C
Do Not Freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
