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407616
Sigma-AldrichIL-1R Antagonist - CAS 566914-00-9 - Calbiochem
IL-1R Antagonist, CAS 566914-00-9, is a cell-permeable, end protected L-valyl derivative. Specifically blocks TIR domain-mediated MyD88/IL1-RI interaction without affecting TLR4/MyD88 interaction.
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MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
A cell-permeable, end protected L-valyl derivative modeled on the MyD88-binding sequence of the TIR (Toll/IL-1R/resistance) domain BB-loop of IL-1RI (type I IL-1 receptor). It specifically inhibits TIR domain-mediated MyD88/IL1-RI interaction without affecting TLR4/MyD88 interaction. It was used successfully to reduce IL-1β-induced fever in mice in vivo and to attenuate IL-1β-induced, but not LPS-induced, activation of MAP kinase signaling cascades in murine lymphocytes and EL4 thymoma cells in vitro.
Catalogue Number
407616
Brand Family
Calbiochem®
Synonyms
BB-loop Mimic, Hydrocinnamoyl-L-valyl Pyrrolidine, TIR Domain Mimic
References
References
Bartfai, T., et al. 2003. Proc. Natl. Acad. Sci. USA100, 7971.
IL-1R Antagonist, CAS 566914-00-9, is a cell-permeable, end protected L-valyl derivative. Specifically blocks TIR domain-mediated MyD88/IL1-RI interaction without affecting TLR4/MyD88 interaction.
Biological Information
Primary Target
TIR domain-mediated MyD88/IL1-RI interaction
Purity
≥95% by HPLC
Physicochemical Information
Cell permeable
Y
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code
Ambient Temperature Only
Toxicity
Standard Handling
Storage
+2°C to +8°C
Do not freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas
Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
产品目录编号
GTIN
407616-10MGCN
04055977211337
407616-25MGCN
04055977211344
Documentation
IL-1R Antagonist - CAS 566914-00-9 - Calbiochem MSDS
IL-1R Antagonist - CAS 566914-00-9 - Calbiochem 分析证书
标题
批号
407616
参考
参考信息概述
Bartfai, T., et al. 2003. Proc. Natl. Acad. Sci. USA100, 7971.
数据表
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
Revision
14-July-2008 RFH
Synonyms
BB-loop Mimic, Hydrocinnamoyl-L-valyl Pyrrolidine, TIR Domain Mimic
Description
A cell-permeable, end protected L-valyl derivative of the MyD88-binding sequence of the TIR (Toll/IL-1R/resistance) domain BB-loop of IL-1RI (type I IL-1 receptor). It specifically inhibits TIR domain-mediated MyD88/IL1-RI interaction without affecting TLR4/MyD88 interaction. It was used successfully to reduce IL-1β-induced fever in mice in vivo and to attenuate IL-1β-induced, but not LPS-induced, activation of MAP kinase signaling cascades in murine lymphocytes and EL4 thymoma cells in vitro.
Form
Colorless oil
Intert gas (Yes/No)
Packaged under inert gas
CAS number
566914-00-9
Chemical formula
C₁₈H₂₆N₂O₂
Structure formula
Purity
≥95% by HPLC
Solubility
DMSO (10 mg/ml) or Ethanol
Storage
+2°C to +8°C
Do Not Freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity
Standard Handling
References
Bartfai, T., et al. 2003. Proc. Natl. Acad. Sci. USA100, 7971.
