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Polycyclic dione that has anti-retroviral activity. Inhibits protein kinase C (IC50 = 3.3 μM). Also known to inhibit casein kinase II (IC50 = 6 nM), MAP kinase (IC50 = 4 nM), and the protein tyrosine activities of the insulin receptor (IC50 = 20-29 nM) and the epidermal growth factor receptor (IC50 = 35 nM).
Catalogue Number
400076
Brand Family
Calbiochem®
Synonyms
Casein Kinase II Inhibitor XI
References
References
Zhang, W., et al. 1997. Cancer Lett.120, 31. Agostinis, P., et al. 1995. Biochem. Pharmacol.49, 1615. Frew, T., et al. 1994. Anticancer Res.14, 2425. Barnard, D.L., et al. 1992. Antiviral Res.17, 63. Takahashi, I., et al. 1989. Biochem. Biophys. Res. Commun.165, 1207.
3.3 µM, 6 nM, 4 nM, 20-29 nM , 35 nM, against protein kinase C, casein kinase II, MAP kinase, the protein tyrosine activities of the insulin receptor, and the epidermal growth factor receptor, respectively
Purity
≥98% by HPLC
Physicochemical Information
Cell permeable
N
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R Phrase
R: 22
Harmful if swallowed.
S Phrase
S: 22-36
Do not breathe dust. Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code
Ambient Temperature Only
Toxicity
Harmful
Storage
+2°C to +8°C
Protect from Light
Protect from light
Do not freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Zhang, W., et al. 1997. Cancer Lett.120, 31. Agostinis, P., et al. 1995. Biochem. Pharmacol.49, 1615. Frew, T., et al. 1994. Anticancer Res.14, 2425. Barnard, D.L., et al. 1992. Antiviral Res.17, 63. Takahashi, I., et al. 1989. Biochem. Biophys. Res. Commun.165, 1207.
数据表
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
Revision
01-December-2015 JSW
Synonyms
Casein Kinase II Inhibitor XI
Description
Polycyclic dione that has anti-retroviral activity. Inhibits protein kinase C (IC50 = 3.3 µM). Also known to inhibit the protein tyrosine kinase activities of the insulin receptor (IC50 = 20-29 nM), the epidermal growth factor receptor (IC50 = 35 nM), casein kinase II (IC50 = 6 nM), and MAP kinase (IC50 = 4 nM). Useful probe for PKC due to its bright red fluorescence emission and photostability. Also see Pseudohypericin (Cat. No. 539590).
Form
Black solid
CAS number
548-04-9
Chemical formula
C₃₀H₁₆O₈
Structure formula
Purity
≥98% by HPLC
Solubility
DMSO (10 mg/ml), Ethanol (1 mg/ml) or Methanol (1 mg/ml)
Storage
Protect from light
+2°C to +8°C
Do Not Freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity
Harmful
Merck USA index
14, 4863
References
Zhang, W., et al. 1997. Cancer Lett.120, 31. Agostinis, P., et al. 1995. Biochem. Pharmacol.49, 1615. Frew, T., et al. 1994. Anticancer Res.14, 2425. Barnard, D.L., et al. 1992. Antiviral Res.17, 63. Takahashi, I., et al. 1989. Biochem. Biophys. Res. Commun.165, 1207.
